6-benzyl-2,3-dihydro-1H-thieno[2,3-b][1,4]thiazine-2-one | 213402-49-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并噻嗪类
• 英文名称: 6-benzyl-2,3-dihydro-1H-thieno[2,3-b][1,4]thiazine-2-one
• 英文别名: 6-benzyl-1H-thieno[2,3-b][1,4]thiazin-2(3H)-one；6-benzyl-1H-thieno[2,3-b][1,4]thiazin-2-one
• CAS: 213402-49-4
• 化学式: C₁₃H₁₁NOS₂
• 分子量: 261.368
• InChiKey: DPLXHRCORGOCPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  82.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-benzyl-2,3-dihydro-1H-thieno[2,3-b][1,4]thiazine-2-one 在 lithium aluminium tetrahydride 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 4.5h， 生成 6-benzyl-2,3-dihydro-1H-thieno[2,3-b][1,4]thiazine-1-carboxylic acid 4-nitrophenyl ester
  参考文献：
  名称：

  Studies on the Chemistry of Thienoannelated O,N- and S,N-Containing Heterocycles. Part 19[1]: Thieno[2,3-b][1,4]thiazines with Calcium Antagonistic and Potassium Opening Activities

  摘要：

  In this study novel substituted 6-benzyl-thieno[2,3-b] [1,4]thiazines with an urea moiety were synthesized. Structural modifications of the amino side chain were carried out with the aim of finding tissue specific compounds. The effects on papillary muscles, right atria, aortic strips, and terminal ilea were investigated. Compounds 10c and 10d showed the most potent negative inotropic effect. The calcium antagonism of all derivatives occurred in a non-competitive manner, which may indicate that they also have potassium channel opening activities.

  DOI：

  10.1002/(sici)1521-4184(200002)333:2/3<58::aid-ardp58>3.0.co;2-l
• 作为产物：
  描述：

  (5-Chlor-4-nitro-2-thienyl)-phenylmethanon 在 三乙基硅烷 、 铁粉 、 potassium carbonate 、 溶剂黄146 作用下， 以 四氢呋喃 、 甲醇 、 水 、 三氟乙酸 为溶剂， 反应 66.5h， 生成 6-benzyl-2,3-dihydro-1H-thieno[2,3-b][1,4]thiazine-2-one
  参考文献：
  名称：

  Studies on the Chemistry of Thienoannelated O,N- and S,N-Containing Heterocycles. Part 19[1]: Thieno[2,3-b][1,4]thiazines with Calcium Antagonistic and Potassium Opening Activities

  摘要：

  In this study novel substituted 6-benzyl-thieno[2,3-b] [1,4]thiazines with an urea moiety were synthesized. Structural modifications of the amino side chain were carried out with the aim of finding tissue specific compounds. The effects on papillary muscles, right atria, aortic strips, and terminal ilea were investigated. Compounds 10c and 10d showed the most potent negative inotropic effect. The calcium antagonism of all derivatives occurred in a non-competitive manner, which may indicate that they also have potassium channel opening activities.

  DOI：

  10.1002/(sici)1521-4184(200002)333:2/3<58::aid-ardp58>3.0.co;2-l

文献信息

• Studies on the chemistry of thienoannelated<i>O,N</i>- and<i>S,N</i>-containing heterocycles. 24 [1]. Synthesis of imidazo[1,5-<i>d</i>]thieno[2,3-<i>b</i>][1,4]-thiazine derivatives as potential receptor ligands
  作者：Thomas Erker、Norbert Handler

  DOI：10.1002/jhet.5570390407

  日期：2002.7

  A facile synthesis of the imidazo[1,5-d]thieno[2,3-b][1,4]thiazine ring system is described. Reaction of 6-benzyl-2,3-dihydro-1H-thieno[2,3-b][1,4]thiazine-2-one (1) with potassium tert-butoxide and diethylchlorophosphate gave intermediate 2 which resulted in the disired ring system after adding the corresponding isocyanides and potassium tert-butoxide.

  描述了咪唑并[1,5- d ]噻吩并[2,3- b ] [1,4]噻嗪环系统的简便合成方法。的6-苄基-2,3-二氢-1-反应ħ -噻吩并[2,3- b ] [1,4]噻嗪-2-酮（1）与钾叔丁醇和氯磷酸二乙酯，得到中间体2，其导致加入相应的异氰化物和叔丁醇钾后，形成不想要的环系统。