3-methoxy-4-(methoxycarbonyloxy)benzoyl chloride | 473424-59-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methoxy-4-(methoxycarbonyloxy)benzoyl chloride
• 英文别名: 3-methoxy-4-methoxycarbonyloxy-benzoyl chloride；3-Methylaether-4-carbomethoxy-protocatechusaeurechlorid；3-Methoxy-4-(carbomethoxy-oxy)-benzoylchlorid；3-Methoxy-4-methoxycarbonyloxy-benzoylchlorid；Carbomethoxy-vanillinsaeurechlorid；3-methoxy-4-[(methoxycarbonyl)oxy]benzoyl chloride；(4-carbonochloridoyl-2-methoxyphenyl) methyl carbonate
• CAS: 473424-59-8
• 化学式: C₁₀H₉ClO₅
• 分子量: 244.631
• InChiKey: SDIDTEDETZUSKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-methoxy-4-(methoxycarbonyloxy)benzoyl chloride 在 sodium hydroxide 、 乙醚 作用下， 生成 2-[(4-羟基-3-甲氧基苯甲酰基)氨基]乙酸
  参考文献：
  名称：

  Fischer,E.; Freudenberg, Justus Liebigs Annalen der Chemie, 1910, vol. 372, p. 36

  摘要：

  DOI：
• 作为产物：
  描述：

  3-methoxy-4-methoxycarbonyloxy-benzoic acid 在 氯化亚砜 作用下， 生成 3-methoxy-4-(methoxycarbonyloxy)benzoyl chloride
  参考文献：
  名称：

  New banana-type liquid crystal with a methoxy group substituted near the central ring

  摘要：

  合成了一种具有热稳定酯键连接、拥有七个环的非手性弯曲核心（香蕉状）向列相物质。该分子结构的创新之处在于，位于分子中心附近苯环的邻位上侧向取代了甲氧基团。该化合物呈现出两种介相；高温段归因于反铁电B2相，而低温段则是一种具有平面内部有序性的近晶相。

  DOI：

  10.1039/b202403a

文献信息

• [EN] DI-VANILLOYL AND TRI-VANILLOYL DERIVATIVES FOR USE IN ANTI-CANCER THERAPY<br/>[FR] DÉRIVÉS DE DI-VANILLOYLE ET DE TRI-VANILLOYLE POUR UNE UTILISATION DANS UNE THÉRAPIE ANTI-CANCÉREUSE
  申请人：UNIV BRUXELLES

  公开号：WO2010043631A1

  公开（公告）日：2010-04-22

  The invention relates to the medical field, more precisely in the field of anti-cancer treatment and treatment of Alzheimer's disease, Parkinson's disease or Pick's disease or for ameliorating symptoms of Down syndrome, providing newly synthesised multi-vanilloyl derivative compounds and their use in the treatment of said disorders.

  这项发明涉及医学领域，更准确地说是在抗癌治疗和治疗阿尔茨海默病、帕金森病或皮克氏病，或改善唐氏综合征症状方面，提供新合成的多香豆酰衍生物化合物及其在治疗上述疾病中的用途。
• Synthesis, phase behaviour and photo-optical properties of bent-core methacrylate with azobenzene group and corresponding side-chain polymethacrylate
  作者：V. Novotná、A. Bobrovsky、V. Shibaev、D. Pociecha、M. Kašpar、V. Hamplová

  DOI：10.1039/c6ra11656f

  日期：——

  In the present work, synthesis of a new photosensitive bent-core monomer and corresponding side-chain polymethacrylate is described. The liquid crystalline (LC) properties were studied by texture observation, calorimetric and electro-optical measurements. Structural parameters of the LC phases were established from X-ray diffraction. Due to presence of the azobenzene group both compounds revealed photosensitivity

  在本工作中，描述了新的光敏弯曲核单体和相应的侧链聚甲基丙烯酸酯的合成。通过纹理观察，量热法和电光测量研究了液晶（LC）性能。LC相的结构参数由X射线衍射确定。由于存在偶氮苯基，两种化合物均显示出光敏性和紫外线辐射可有效诱导E - Z异构化过程。分析了聚甲基丙烯酸酯的旋涂膜的光光学性质，发现偏振光的照射使发色团在垂直于入射光的偏振面的方向上对准。与退火的LC膜相比，在非晶化膜中光取向的进行更为有效。
• Di-Vanilloyl And Tri-Vanilloyl Derivatives For Use In Anti-Cancer Therapy
  申请人：Kiss Robert

  公开号：US20110280940A1

  公开（公告）日：2011-11-17

  The invention relates to the medical field, more precisely in the field of anti-cancer treatment and treatment of Alzheimer's disease, Parkinson's disease or Pick's disease or for ameliorating symptoms of Down syndrome, providing newly synthesised multi-vanilloyl derivative compounds and their use in the treatment of said disorders.

  该发明涉及医学领域，更精确地说是抗癌治疗和治疗阿尔茨海默病、帕金森病或皮克氏病或改善唐氏综合症症状的领域，提供新合成的多香豆酰衍生物化合物及其在治疗上述疾病中的应用。
• Reactions of Vanillin and its Derived Compounds. XXI.¹ Amides of Vanillic and 3-Ethoxy-4-hydroxybenzoic Acids^2,3
  作者：Irwin A. Pearl、Donald L. Beyer

  DOI：10.1021/ja01107a021

  日期：1953.6
• Photo-optical properties of amorphous and crystalline films of azobenzene-containing photochromes with bent-shaped molecular structure
  作者：Alexey Bobrovsky、Valery Shibaev、Vĕra Hamplová、Alexej Bubnov、Vladimíra Novotná、Miroslav Kašpar、Alexey Piryazev、Denis Anokhin、Dimitri Ivanov

  DOI：10.1016/j.jphotochem.2015.10.021

  日期：2016.2

  A comparative study of the photo-optical properties and the photo-orientation processes in thin films of the bent-shaped azobenzene-containing compounds with different molecular structure was performed. For this purpose three new compounds were designed and prepared: two of these compounds with a symmetric bent-shaped molecular structure incorporate two azobenzene chromophores with different length of alkyl chains (6 and 8 methylene units), the third bent-shaped compound possesses only one azobenzene fragment. The effect of molecular and supramolecular structure, thermal prehistory of the films, wavelengths of the excitation light on the photo-optical properties, photoorientation processes and films morphology was revealed. It was shown that UV-irradiation leads to E-Z isomerization of azobenzene fragments in both amorphousized and crystalline films of the synthesized substances. This process is partially suppressed in crystalline films, but, nevertheless, UV-irradiation of the bichromophoric compounds results in transition from crystalline to amorphous state and decrease in the surface roughness. Irradiation of amorphousized films with polarized visible and UV-light induces the photoorientation of chromophores in direction perpendicular to the polarization plane of the incident light. Relatively high values of photoinduced dichroism in the bent-shaped compounds (D similar to 0.60-0.65) are comparable with other azobenzene-containing rod-shaped systems. Photoinduced isothermal melting and photoorientation processes could be served for the photo-optical data recording and storage. (C) 2015 Elsevier B.V. All rights reserved.