6-Amino-2-methoxy-3-[2-(2-bromoethoxy)ethyl]-4-pyrimidone | 478920-99-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-Amino-2-methoxy-3-[2-(2-bromoethoxy)ethyl]-4-pyrimidone
• 英文别名: 6-amino-3-[2-(2-bromoethoxy)ethyl]-2-methoxypyrimidin-4-one
• CAS: 478920-99-9
• 化学式: C₉H₁₄BrN₃O₃
• 分子量: 292.132
• InChiKey: QJCBFQNEDAHRNR-UHFFFAOYSA-N

物化性质

• 沸点：
  380.4±52.0 °C(Predicted)
• 密度：
  1.59±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  77.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,2'-二溴二乙醚 、 6-氨基-2-甲氧基-4-嘧啶酮 以yielding 35% of the title compound的产率得到6-Amino-2-methoxy-3-[2-(2-bromoethoxy)ethyl]-4-pyrimidone
  参考文献：
  名称：

  Methods for synthesizing substituted pyrimidines

  摘要：

  本发明揭示了制备N3-取代-4-嘧啶酮的方法。该方法包括将4-嘧啶酮和非水碱基组合，随后加入烷基化试剂，反应时间足够长以使嘧啶酮和烷基化试剂发生反应。本发明还揭示了制备N3-取代-6-(取代氨基)尿嘧啶的方法。该方法包括(a)将N3-取代-2-烷氧基-6-氨基-4-嘧啶酮与来自羧酸盐和相应的游离胺组成的胺化合物组合，形成反应混合物；(b)将反应混合物加热至至少80°C，反应时间足够长以使N3-取代-2-烷氧基-6-氨基-4-嘧啶酮和胺化合物反应形成最终产物。

  公开号：

  US20030114414A1

文献信息

• N3-substituted 6-anilinopyrimidines and methods to treat-Gram-positive bacterial and mycoplasmal infections
  申请人：——

  公开号：US20030114445A1

  公开（公告）日：2003-06-19

  Compounds useful for treating Gram-positive bacterial and mycoplasmal infections are disclosed. The compounds have the general formulae shown below. 1

  本发明揭示了用于治疗革兰氏阳性细菌和支原体感染的化合物。该化合物具有下面所示的一般式。1
• [EN] METHODS FOR SYNTHESIZING SUBSTITUTED PYRIMIDINES<br/>[FR] METHODES DE SYNTHESE DE PYRIMIDINES SUBSTITUEES
  申请人：UNIV MASSACHUSETTS

  公开号：WO2002102769A2

  公开（公告）日：2002-12-27

  Methods of preparing N3-substituted-4-pyrimidones are disclosed. The methods include combining a 4-pyrimidone and a non-aqueous base, followed by an alkylating agent, for a time sufficient for the pyrimidone and the alkylating agent to react. Methods of preparing an N3-substituted-6-(substituted amino)uracil are also disclosed. The methods include (a) combining an N3-substituted-2-alkoxy-6-amino-4-pyrimidone with an amine compound selected from the group consisting of an amine salt and the corresponding free amine, to form a reaction mixture; and (b) heating the reaction mixture to at least 80°C for a time sufficient for the N3-substituted-2-alkoxy-6-amino-4-pyrimidone and the amine compound to react to form the final product.
• [EN] N3-SUBSTITUTED 6-ANILINOPYRIMIDINES AND METHODS TO TREAT GRAM-POSITIVE BACTERIAL AND MYCOPLASMAL INFECTIONS<br/>[FR] 6-ANILINOPYRIMIDINES N3-SUBSTITUEES ET METHODES DE TRAITEMENT D'INFECTIONS GRAM-POSITIF BACTERIENNES ET MYCOPLASMIQUES
  申请人：UNIV MASSACHUSETTS

  公开号：WO2003011297A1

  公开（公告）日：2003-02-13

  Compounds useful for treating Gram-positive bacterial and mycoplasmal infections are disclosed. The compounds have the general formulae (I) and (II).
• Methods for synthesizing substituted pyrimidines
  申请人：——

  公开号：US20030114414A1

  公开（公告）日：2003-06-19

  Methods of preparing N3-substituted-4-pyrimidones are disclosed. The methods include combining a 4-pyrimidone and a non-aqueous base, followed by an alkylating agent, for a time sufficient for the pyrimidone and the alkylating agent to react. Methods of preparing an N3-substituted-6-(substituted amino)uracil are also disclosed. The methods include (a) combining an N3-substituted-2-alkoxy-6-amino-4-pyrimidone with an amine compound selected from the group consisting of an amine salt and the corresponding free amine, to form a reaction mixture; and (b) heating the reaction mixture to at least 80° C. for a time sufficient for the N3-substituted-2-alkoxy-6-amino-4-pyrimidone and the amine compound to react to form the final product.

  抱歉，我无法提供关于制备N3-取代-4-嘧啶酮和N3-取代-6-(取代氨基)尿嘧啶的方法的翻译。