2-[(Bromoacetyl)oxy]ethyl prop-2-enoate | 65387-25-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(Bromoacetyl)oxy]ethyl prop-2-enoate
• 英文别名: 2-(2-bromoacetyl)oxyethyl prop-2-enoate
• CAS: 65387-25-9
• 化学式: C₇H₉BrO₄
• 分子量: 237.05
• InChiKey: QIVKVDKEYJVXCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• SURFACES COMPRISING ATTACHED QUORUM SENSING MODULATORS
  申请人：The Trustees of Princeton University

  公开号：US20180125066A1

  公开（公告）日：2018-05-10

  The invention relates to compositions comprising QS modulating molecules attached to a surface via a linker. This QS modulator attached surface can then be used to modulate QS, biofilm production, biofilm streamer production and/or virulence factor production. The length of the linker that attaches the QS modulating molecule to the surface as well as the surface coverage density are features that impact QS modulation on surfaces. These QS modulator attached surfaces can be used to treat areas known to contain human pathogens notorious for causing hospital-acquired infections as well as fatal infections that occur outside of health care settings. Other surfaces that can be coated according to embodiments of the invention include abiotic materials, such as intravenous catheters, implants, medical devices, and cooling towers. Preferred microorganisms that can be treated with the compositions of the invention include, but are not limited to S. aureus and/or P. aeruginosa . The QS modulator attached surface also demonstrates exceptional stability.
• DIAGNOSTIC AND THERAPEUTIC QUORUM-SENSING-MANIPULATION MOLECULES THAT ARE TRACKABLE FOR HEALTH-CARE AND INDUSTRIAL SYSTEMS.
  申请人：The Trustees of Princeton University

  公开号：US20180346525A1

  公开（公告）日：2018-12-06

  According to present invention embodiments, a trackable moiety can be attached to a quorum sensing (QS) molecule to form a QS modulating conjugate. QS modulating conjugates retain their activity for QS manipulation and are able to be detected by imaging techniques. The QS portion of the QS modulating conjugate can play a role in affecting bacterial behaviors, such as, inhibition of biofilms or disruption of toxin production, while the trackable moiety of the QS modulating conjugate enables monitoring, visualization in real time of its binding to the receptor on the bacterial surface, and the location of the bacterium itself, for example, in a biofilm and/or at an infection site. Since binding of the QS modulating conjugate to its cognate receptor is specific, the QS modulating conjugate can be used for diagnostic applications by enabling pinpointing of specific bacteria at infection sites.
• [EN] SURFACES COMPRISING ATTACHED QUORUM SENSING MODULATORS<br/>[FR] SURFACES COMPRENANT DES MODULATEURS DE DÉTECTION DU QUORUM FIXÉS
  申请人：UNIV PRINCETON

  公开号：WO2016176146A1

  公开（公告）日：2016-11-03

  The invention relates to compositions comprising QS modulating molecules attached to a surface via a linker. This QS modulator attached surface can then be used to modulate QS, biofilm production, biofilm streamer production and/or virulence factor production. These QS modulator attached surfaces can be used to treat areas known to contain human pathogens notorious for causing hospital-acquired infections as well as fatal infections that occur outside of health care settings. Other surfaces that can be coated according to embodiments of the invention include abiotic materials, such as intravenous catheters, implants, medical devices, and cooling towers. Preferred microorganisms that can be treated with the compositions of the invention include, but are not limited to S. aureus and/or P. aeruginosa.