N-(2-(4-amino-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methanesulfonamide | 1374227-37-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-(4-amino-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methanesulfonamide
• 英文别名: N-[2-[[4-amino-6-(3,4,5-trimethoxyanilino)-1,3,5-triazin-2-yl]amino]phenyl]methanesulfonamide
• CAS: 1374227-37-8
• 化学式: C₁₉H₂₃N₇O₅S
• 分子量: 461.502
• InChiKey: KOGQFMPXPVPNPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  171
• 氢给体数：
  4
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  2-甲磺酰氨基苯胺 在 氨 、 palladium diacetate 、 caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 为溶剂， 反应 1.17h， 生成 N-(2-(4-amino-6-(3,4,5-trimethoxyphenylamino)-1,3,5-triazin-2-ylamino)phenyl)methanesulfonamide
  参考文献：
  名称：

  High yielding microwave-assisted synthesis of tri-substituted 1,3,5-triazines using Pd-catalyzed aryl and heteroarylamination

  摘要：

  A rapid and efficient Pd-catalyzed aryl and heteroarylamination under microwave irradiation has been developed for various tri-substituted triazines that can serve as versatile building blocks for both supramolecular and medicinal chemistry research. Particularly valuable features of this method included the short reaction time, good yield, and convenient operation. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.041

文献信息

• High yielding microwave-assisted synthesis of tri-substituted 1,3,5-triazines using Pd-catalyzed aryl and heteroarylamination
  作者：Pascal Dao、Christiane Garbay、Huixiong Chen

  DOI：10.1016/j.tet.2012.03.041

  日期：2012.5

  A rapid and efficient Pd-catalyzed aryl and heteroarylamination under microwave irradiation has been developed for various tri-substituted triazines that can serve as versatile building blocks for both supramolecular and medicinal chemistry research. Particularly valuable features of this method included the short reaction time, good yield, and convenient operation. (C) 2012 Elsevier Ltd. All rights reserved.