chloro-(2-methoxy-phenyl)-acetonitrile | 90537-16-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: chloro-(2-methoxy-phenyl)-acetonitrile
• 英文别名: (+/-)-Chlor-(2-methoxy-phenyl)-essigsaeure-nitril；Chlor-(2-methoxy-phenyl)-acetonitril；α-Chlor-2-methoxy-benzylcyanid；Benzeneacetonitrile, alpha-chloro-2-methoxy-；2-chloro-2-(2-methoxyphenyl)acetonitrile
• CAS: 90537-16-9
• 化学式: C₉H₈ClNO
• mdl: MFCD16104972
• 分子量: 181.622
• InChiKey: OLDUYWOZQPNVEK-UHFFFAOYSA-N

物化性质

• 熔点：
  43-44 °C
• 沸点：
  132-133 °C(Press: 9 Torr)
• 密度：
  1.2040 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  33
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  chloro-(2-methoxy-phenyl)-acetonitrile 生成 N-[2-bromo-5-(2-methoxy-phenyl)-thiazol-4-yl]-acetamide
  参考文献：
  名称：

  Polyfunctional Aliphatic Compounds. IV. The Cyclization of Nitriles by Halogen Acids. A New Synthesis of Thiazoles

  摘要：

  DOI：

  10.1021/jo01042a036
• 作为产物：
  描述：

  2-羟基-2-(2-甲氧基苯基)乙腈 在 乙醚 作用下， 生成 chloro-(2-methoxy-phenyl)-acetonitrile
  参考文献：
  名称：

  Inadequate preanesthesia equipment checks in a simulator

  摘要：

  Purpose: To assess how completely anesthesiologists check their machinery and equipment before use, and to determine what influence seniority age and type of practice may have on checking practices.Methods: One hundred and twenty anesthesiologists were videotaped during a simulated anesthesia session. Each participant was scored by an assessor according to the number of items checked prior to the induction of anesthesia. A checklist of 20 items derived from well-publicized, international standards was used.Results: Participants were grouped according to their type of practice. Overall, mean scores were low. The ideal score was 20. There were no differences among university anesthesiologists (mean score 10, 1, standard deviation 4.3), community anesthesiologists (7.5 +/- 4.3) and anesthesia residents (9.0 +/- 3.8), Each of these groups scored, on average, better than medical students (3.6 +/- 3.7) (P < 0.05). Neither age (r = 0.15, P > 0.1) nor number of years in practice (r = -0.18, P > 0.1) correlated with score.Conclusions: Our study suggests that the equipment-checking practices of anesthesiologists require considerable improvement when compared with national and international standards. Possible reasons for this are discussed and some remedial suggestions are made.

  DOI：

  10.1007/bf03024868

文献信息

• 1-H-3-arylpirrolidine-2,4-dione derivatives
  申请人：——

  公开号：US20040019061A1

  公开（公告）日：2004-01-29

  The invention concerns 1-H-3-arylpyrrolidine-2,4-dione derivatives of formula (I), 1 in which A, B, G, X, Y and Z are as defined in the description, methods of preparing them and intermediates used in their preparation. The compounds of formula (I) are suitable for use as pest-control agents.

  本发明涉及式(I)的1-H-3-arylpyrrolidine-2,4-二酮衍生物，其中A、B、G、X、Y和Z如描述中所定义，以及用于制备它们的中间体。式(I)的化合物适用于作为杀虫剂。
• 86. A novel pyrimidine synthesis. Part II. 4-Amino-5-arylpyrimidines
  作者：W. H. Davies、A. W. Johnson、H. A. Piggott

  DOI：10.1039/jr9450000352

  日期：——
• US6472419B1
  申请人：——

  公开号：US6472419B1

  公开（公告）日：2002-10-29
• US6939888B2
  申请人：——

  公开号：US6939888B2

  公开（公告）日：2005-09-06
• Inadequate preanesthesia equipment checks in a simulator
  作者：Allysan Armstrong-Brown、J Hugh Devitt、Matt Kurrek、Marsha Cohen

  DOI：10.1007/bf03024868

  日期：2000.10

  Purpose: To assess how completely anesthesiologists check their machinery and equipment before use, and to determine what influence seniority age and type of practice may have on checking practices.Methods: One hundred and twenty anesthesiologists were videotaped during a simulated anesthesia session. Each participant was scored by an assessor according to the number of items checked prior to the induction of anesthesia. A checklist of 20 items derived from well-publicized, international standards was used.Results: Participants were grouped according to their type of practice. Overall, mean scores were low. The ideal score was 20. There were no differences among university anesthesiologists (mean score 10, 1, standard deviation 4.3), community anesthesiologists (7.5 +/- 4.3) and anesthesia residents (9.0 +/- 3.8), Each of these groups scored, on average, better than medical students (3.6 +/- 3.7) (P < 0.05). Neither age (r = 0.15, P > 0.1) nor number of years in practice (r = -0.18, P > 0.1) correlated with score.Conclusions: Our study suggests that the equipment-checking practices of anesthesiologists require considerable improvement when compared with national and international standards. Possible reasons for this are discussed and some remedial suggestions are made.