2-苯基-2-己基甘氨酸 | 868635-12-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-苯基-2-己基甘氨酸
• 英文名称: 2-phenyl-2-hexylglycine
• 英文别名: I+/--Amino-I+/--hexylbenzeneacetic acid；2-amino-2-phenyloctanoic acid
• CAS: 868635-12-5
• 化学式: C₁₄H₂₁NO₂
• 分子量: 235.326
• InChiKey: LMLVNABYYIGESG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-苯基-2-己基甘氨酸 在 HEPES buffer 乙二胺四乙酸 、 potassium chloride 、 5-ethylsulfanylmethyl-3-hydroxy-2-methylpyridine-4-carbaldehyde 作用下， 以 水 、 乙腈 为溶剂， 生成 苯庚酮
  参考文献：
  名称：

  Hydrophobic and electronic factors in the design of dialkylglycine decarboxylase mimics

  摘要：

  The first functional catalytic mimic of the enzyme dialkylglycine decarboxylase is described. This system utilizes a hydrophobically modified polyethylenimine polymer, a pyridoxamine cofactor, and a 2-aryl-2-alkylglycine sacrificial amine source to convert alpha-keto acids to alpha-amino acids at biologically relevant temperatures with multiple turnovers of the pyridoxamine catalyst. The effects of hydrophobic and electronic factors in the 2,2-disubstituted sacrificial amine source and the pyridoxamine catalyst on turnover frequency and turnover number are explored. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.05.019
• 作为产物：
  描述：

  5-phenyl-5-hexylhydantoin 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 24.0h， 以81%的产率得到2-苯基-2-己基甘氨酸
  参考文献：
  名称：

  Hydrophobic and electronic factors in the design of dialkylglycine decarboxylase mimics

  摘要：

  The first functional catalytic mimic of the enzyme dialkylglycine decarboxylase is described. This system utilizes a hydrophobically modified polyethylenimine polymer, a pyridoxamine cofactor, and a 2-aryl-2-alkylglycine sacrificial amine source to convert alpha-keto acids to alpha-amino acids at biologically relevant temperatures with multiple turnovers of the pyridoxamine catalyst. The effects of hydrophobic and electronic factors in the 2,2-disubstituted sacrificial amine source and the pyridoxamine catalyst on turnover frequency and turnover number are explored. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.05.019

文献信息

• PROCÉDÉ DE DÉTECTION ET/OU D'IDENTIFICATION DE CLOSTRIDIUM DIFFICILE
  申请人：Biomérieux

  公开号：EP2235202A2

  公开（公告）日：2010-10-06
• METHOD FOR DETECTING AND/OR IDENTIFYING CLOSTRIDIUM DIFFICILE
  申请人：Asir Kerry

  公开号：US20100279330A1

  公开（公告）日：2010-11-04

  The invention relates to a method for detecting and/or identifying Clostridium difficile , characterized in that it comprises the following steps: a) providing a reaction medium comprising at least one beta-glucosidase substrate capable of identifying C. difficile, b) inoculating the medium with a biological sample to be tested, c) allowing for incubation, and d) detecting the hydrolysis of the beta-glucosidase substrate, indicative of the presence of Clostridium difficile. The invention also relates to a reaction medium for the detection and/or the identification of Clostridium difficile , that comprises at least one beta-glucosidase substrate capable of identifying C. difficile.
• US8404460B2
  申请人：——

  公开号：US8404460B2

  公开（公告）日：2013-03-26
• [EN] METHOD FOR DETECTING AND/OR IDENTIFYING CLOSTRIDIUM DIFFICILE<br/>[FR] PROCÉDÉ DE DÉTECTION ET/OU D'IDENTIFICATION DE CLOSTRIDIUM DIFFICILE
  申请人：BIOMERIEUX SA

  公开号：WO2009092982A2

  公开（公告）日：2009-07-30

  L'invention concerne un procédé de détection et/ou d'identification de Clostridium difficile, caractérisé en ce qu'il comprend les étapes suivantes : a) disposer d'un milieu réactionnel comprenant au moins un substrat de beta-glucosidase, apte à l'identification de C. difficile, b) ensemencer le milieu avec un échantillon biologique à tester, c) laisser incuber, et d) détecter l'hydrolyse du substrat de beta-glucosidase indiquant la présence de Clostridium difficile. L'invention concerne également un milieu réactionnel pour la détection et/ou l'identification de Clostridium difficile comprenant au moins un substrat de beta- glucosidase, apte à l'identification de C. difficile.