4-[1-(2-Methoxyethyl)-5-nitrobenzimidazol-2-yl]aniline | 1243576-34-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 4-[1-(2-Methoxyethyl)-5-nitrobenzimidazol-2-yl]aniline
• CAS: 1243576-34-2
• 化学式: C₁₆H₁₆N₄O₃
• 分子量: 312.328
• InChiKey: IQIASPFEVXZELF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  98.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  对氨基苯甲醛 、 2-氟-5-硝基苯胺 、 2-甲氧基乙胺 反应 8.0h， 以77%的产率得到4-[1-(2-Methoxyethyl)-5-nitrobenzimidazol-2-yl]aniline
  参考文献：
  名称：

  A one-pot three-component reaction to access 1-alkyl-2-aryl-5-nitrobenzimidazoles under solvent-free conditions

  摘要：

  A novel and expeditious method to access 1-alkyl-2-aryl-5-nitiobenzimidazoles has been developed Enlisting solvent-free conditions, 2-fluoro-5-nitroaniline, a primary amine, and substituted aldehyde were melted together in one-pot to generate a variety of 1-alkyl-2-aryl-5-nitrobenzimidazoles (C) 2010 Elsevier Ltd All lights reserved

  DOI：

  10.1016/j.tetlet.2010.06.094

文献信息

• A one-pot three-component reaction to access 1-alkyl-2-aryl-5-nitrobenzimidazoles under solvent-free conditions
  作者：F. Anthony Romero、Remond Moningka

  DOI：10.1016/j.tetlet.2010.06.094

  日期：2010.8

  A novel and expeditious method to access 1-alkyl-2-aryl-5-nitiobenzimidazoles has been developed Enlisting solvent-free conditions, 2-fluoro-5-nitroaniline, a primary amine, and substituted aldehyde were melted together in one-pot to generate a variety of 1-alkyl-2-aryl-5-nitrobenzimidazoles (C) 2010 Elsevier Ltd All lights reserved