1,5-dibromoheptane | 1622-10-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 英文名称: 1,5-dibromoheptane
• 英文别名: 1,5-dibromo-heptane；1,5-Dibrom-heptan；1,5-Dibromheptan
• CAS: 1622-10-2
• 化学式: C₇H₁₄Br₂
• 分子量: 257.996
• InChiKey: PKEIGZIZGNPNLM-UHFFFAOYSA-N

物化性质

• 沸点：
  224.92°C (estimate)
• 密度：
  1.5944 (estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2903399090

反应信息

• 作为反应物：
  描述：

  1,5-dibromoheptane 、 硫化碱 以70%的产率得到
  参考文献：
  名称：

  GORDADZE G. N.; BARYKINA L. R.; BEZINGER N. N.; BRODSKIJ E. S.; VOLYNSKIJ+, ORGAN. SOEDIN. SERY. T. 2. RIGA, 1980, 314-325

  摘要：

  DOI：
• 作为产物：
  描述：

  丁基环丙烷 在 N-溴代丁二酰亚胺(NBS) 、 溴 作用下， 以 二氯甲烷 为溶剂， 生成 1,5-dibromoheptane
  参考文献：
  名称：

  Reactions of alkylcyclopropanes with bromine and with hydrogen bromide

  摘要：

  DOI：

  10.1021/ja00421a024

文献信息

• THE REACTION OF 2-ALKYLTETRAHYDROPYRANS WITH ANILINE OVER ACTIVATED ALUMINA
  作者：H. P. Richards、A. N. Bourns

  DOI：10.1139/v55-172

  日期：1955.9.1

  The vapor-phase reaction over activated alumina of 2-ethyltetrahydropyran with aniline gave 1-phenyl-2-ethylpiperidine, 1-phenyl-2-propylpyrrolidine, N-phenyl-4-heptenylamine, and N-phenyl-5-heptenylamine. 2-Methyltetrahydropyran with aniline gave 1-phenyl-2-methylpiperidine, 1-phenyl-2-ethylpyrrolidine, N-phenyl-4-hexenylamine, and N-phenyl-5-hexenylamine. The structures of the cyclic amines were confirmed by independent syntheses. The unsaturated secondary amines were reduced to known N-alkylanilines and degraded by ozonolysis. A mechanism has been proposed to account for the formation of these products.

  在活性氧化铝上的2-乙基四氢吡喃与苯胺的气相反应产生了1-苯基-2-乙基哌啶、1-苯基-2-丙基吡咯烷、N-苯基-4-庚烯胺和N-苯基-5-庚烯胺。2-甲基四氢吡喃与苯胺反应产生了1-苯基-2-甲基哌啶、1-苯基-2-乙基吡咯烷、N-苯基-4-己烯胺和N-苯基-5-己烯胺。这些环状胺的结构已通过独立合成得到确认。不饱和二级胺被还原为已知的N-烷基苯胺，并通过臭氧化反应降解。已提出了一个机理来解释这些产物的形成。
• [EN] CONDENSED PENTACYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF FLAVIVIRIDAE INFECTIONS<br/>[FR] DÉRIVÉS PENTACYCLIQUES CONDENSÉS DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT D'INFECTIONS DE FLAVIVIRIDAE
  申请人：GENELABS TECH INC

  公开号：WO2009086139A1

  公开（公告）日：2009-07-09

  Provided are compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds and compositions are useful for treating viral infections caused by the Flaviviridae family of viruses.

  提供的是式（I）的化合物或其药学上可接受的盐或溶剂。这些化合物和组合物可用于治疗由黄病毒科病毒引起的病毒感染。
• Electrophotographic organophotoreceptors with novel charge transport compounds
  申请人：SAMSUNG Electronics Co. Ltd.

  公开号：US20030219662A1

  公开（公告）日：2003-11-27

  Charge transport compounds are described that have a multiple number of hydrazone-bridged heterocyclic groups (especially julolidine groups, carbazole groups, triarylamine groups and (N,N-disubstituted)arylamine groups such as dialkarylamine groups (e.g. dimethylphenylamine; methylethylphenylamine, dipropylphenylamine, ethylepropylphenylamine, ethylbutylnaphthylamine, etc.), alkyldiarylamine groups (e.g. methyldiphenylamino, ethyldiphenylamino, etc), and triarylamino groups (e.g., triphenyl amino, trinaphthylamino, etc)) connected by a central bridging group. An example of charge transport compounds are those having the following generic formula: (R-Q)n-Y  Formula I wherein R is selected from the group consisting of julolidine ring groups, carbazole ring groups, and and (N,N-disubstituted)arylamine groups; Q comprises an aromatic hydrazone linking group, such as 1 Y comprises a bridging group between R-Q- groups, such as a bond, carbon atom, nitrogen atom, oxygen atom, sulfur atom, a methylene group; Z is an aryl group, preferably a phenyl group or naphthyl group; X is a linking group, preferably a methylene group, and for example having the formula —(CH 2 ) m — (branched or linear), where m is an integer between 0 and 20, inclusive, and one or more of the methylene groups is optionally replaced by an oxygen atom, a carbonyl group, urethane, urea, an ester group, a —NR 6 group, a CHR 7 group, or a CR 8 R 9 group where R 6 , R 7 , R 8 , and R 9 are, independently, H, an alkyl group, or aryl group; and n is an integer between 2 and 6, inclusive. An organic photoreceptor includes that compound and (b) a charge generating compound; and (c) an electrically conductive substrate.

  描述了一种具有多个醛肼桥联杂环基团（尤其是茱萸啉基团、咔唑基团、三芳基胺基团和（N，N-二取代）芳胺基团，例如二芳基胺基团（例如二甲基苯胺；甲基乙基苯胺、二丙基苯胺、乙基丙基苯胺、乙基丁基萘胺等）、烷基二芳基胺基团（例如甲基二苯胺基、乙基二苯胺基等）和三芳基胺基团（例如三苯基氨基、三萘基氨基等））的电荷传输化合物，它们由中心桥接基团连接。电荷传输化合物的一个例子是具有以下通用式的化合物：（R-Q）n-Y Formula I，其中R选自茱萸啉环基团、咔唑环基团和（N，N-二取代）芳胺基团的群体；Q包括芳香醛肼连接基团，例如1；Y包括连接R-Q-基团的桥接基团，例如键、碳原子、氮原子、氧原子、硫原子、亚甲基基团；Z是芳基团，优选为苯基或萘基；X是连接基团，优选为亚甲基基团，例如具有公式—（CH2）m—（支链或直链），其中m是0到20之间的整数，包括，其中一个或多个亚甲基基团可选择地被氧原子、羰基、脲、尿素、酯基、—NR6基团、CHR7基团或CR8R9基团（其中R6、R7、R8和R9独立地为H、烷基或芳基）所替代；n是2到6之间的整数。有机光感受器包括该化合物和（b）电荷生成化合物；以及（c）电导基板。
• The Schartz-Metterclume Method
  作者：Dagobert D. Manteltasche、Otto I.Q. Besser-Wisser

  DOI：10.1177/095169280201400108

  日期：2002.1

  This article describes a parsimonious statistical method for deducing everything that can be known about the unknown by analysing anything that happens to be known about the known. Schartz Metterclume (SM) is a revolutionary new breakthrough in the social sciences that builds upon the synergies of higher mathematics, discourse analysis, rational choice and neo-postdistanciationalist theory. Exhaustive testing of the method shows that it unfailingly produces correct estimates of the causal effects of unknown variables. Indeed the less that is known about the phenomenon under investigation in the first place, the more precise and robust the statistical results of SM are.

  A brief layman’s account of a parsimonious statistical method of deducing everything that can be known about the unknown by analysing anything that happens to be known about the known.

  SM = BS²

  本文描述了一种简约的统计方法，通过分析已知的任何事物来推断未知事物的所有已知信息。Schartz Metterclume（SM）是社会科学领域的一项革命性的新突破，它建立在高等数学、话语分析、理性选择和新后距离主义理论的协同作用之上。对该方法的彻底测试表明，它无疑会产生正确的未知变量因果效应的估计结果。事实上，对于研究对象一开始所知道的越少，SM的统计结果就越精确、越稳健。

  这是一个关于通过分析已知的任何事物来推断未知事物的所有已知信息的简约统计方法的简要的通俗解释。

  SM = BS²

• Compound
  申请人：Toda Ayako

  公开号：US20050261177A1

  公开（公告）日：2005-11-24

  This invention relates to new polypeptide compound represented by the following general formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.

  本发明涉及一种由以下一般式（I）表示的新多肽化合物：其中R1、R2、R3、R4、R5和R6如描述中所定义或其盐，具有抗微生物活性（特别是抗真菌活性），抑制β-1,3-葡聚糖合酶的活性，制备其的方法，包含其的药物组合物，以及用于预防和/或治疗包括肺孢子虫感染（例如肺孢子虫肺炎）在内的人类或动物的传染病的方法。