fluoren-2-yl-acetonitrile | 37411-83-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: fluoren-2-yl-acetonitrile
• 英文别名: Fluoren-2-yl-acetonitril；2-Cyanmethyl-fluoren；2-fluoreneacetonitrile；2-Cyanomethylfluoren；Fluorene-2-acetonitrile；2-(9H-fluoren-2-yl)acetonitrile
• CAS: 37411-83-9
• 化学式: C₁₅H₁₁N
• 分子量: 205.259
• InChiKey: SHAGTWFNJIKVDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  fluoren-2-yl-acetonitrile 在 镍 氢气 作用下， 生成 2-(β-Aminoaethyl)-fluoren
  参考文献：
  名称：

  Dixit,V.M. et al., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1978, vol. 16, p. 124 - 128

  摘要：

  DOI：
• 作为产物：
  描述：

  fluoren-2-yl-acetic acid amide 在 phosphorus pentoxide 作用下， 生成 fluoren-2-yl-acetonitrile
  参考文献：
  名称：

  Dixit,V.M. et al., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1978, vol. 16, p. 124 - 128

  摘要：

  DOI：

文献信息

• Method of using fluorene-2-acetic acid derivatives
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US03989841A1

  公开（公告）日：1976-11-02

  Novel fluorene-2-acetic acid derivatives and methods for preparing these derivatives are provided. Inflammatory conditions may be treated by administering these novel compounds. Additionally, it has been found that the treatment of inflammatory conditions is a new use for certain known compounds; specifically, fluorene-2-acetic acid and its 7-halo, 7-amino, and 7-nitro derivatives.

  提供了新颖的芴-2-乙酸衍生物及其制备方法。可以通过给予这些新颖化合物来治疗炎症性疾病。此外，发现治疗炎症性疾病是某些已知化合物的新用途；具体来说，是芴-2-乙酸及其7-卤、7-氨基和7-硝基衍生物。
• Fluorene-2-acetic acids and derivatives, process and method of using
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04052436A1

  公开（公告）日：1977-10-04

  Fluorene-2-glyoxylic acid, 7-substituted derivatives thereof, and ester derivatives thereof are disclosed as useful for the treatment of inflammatory conditions.

  本发明揭示了荧蒽-2-乙酸，其7-取代衍生物和酯衍生物的治疗炎症状况的用途。
• v. Braun; Engel, Chemische Berichte, 1924, vol. 57, p. 193
  作者：v. Braun、Engel

  DOI：——

  日期：——
• Ore-forming fluids in the dongping gold deposit, northwestern Hebei Province
  作者：Hongrui Fan、Yihan Xie、Mingguo Zhai

  DOI：10.1007/bf02907204

  日期：2001.8

  The Dongping gold deposit is contained within an inner contacting zone of the Hercynian Shuiquangou alkali syenite. The ores occur as veins or as replacement bodies. Fluid inclusion observation shows that in early and main mineralizing stages inclusion types are gas and gas-liquid inclusions, respectively. Gas inclusions occur in isolation in vein quartz, their homogenization temperature is 372-306 degreesC, and salinity 3.7-1.0 wt% NaCl. Gas-liquid inclusions occur in clusters or healed fractures but do not cut quartz boundary with homogenization temperature 342-267 degreesC and salinity 1.9-0.8 wt% NaCl. Stable isotope measurements show that at main gold mineralization, hydrogen and oxygen isotopic ratios of the mineralizing fluids are -70.8 parts per thousand -108.4 parts per thousand and 2.44 parts per thousand -4.05 parts per thousand, respectively. Primary ore fluids in Dongping are higher temperature and lower salinity NaCl-CO2-H2O fluids, and come from Yanshanian granitic magmatism. Fluid immiscibility, fluid-rock interactions and meteoric water adding were main reasons for gold deposition.
• DIXIT V. M.; KHANNA J. M.; ANAND N., INDIAN J. CHEM., 1978, B16, NO 2, 124-128
  作者：DIXIT V. M.、 KHANNA J. M.、 ANAND N.

  DOI：——

  日期：——