(Z)-2-fluoronon-2-enenitrile | 140137-21-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 英文名称: (Z)-2-fluoronon-2-enenitrile
• CAS: 140137-21-9
• 化学式: C₉H₁₄FN
• 分子量: 155.215
• InChiKey: ALPIRDUKLFXXKJ-CLFYSBASSA-N

物化性质

• 沸点：
  200.9±15.0 °C(Predicted)
• 密度：
  0.916±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  正辛醛 、 (1,3-benzothiazol-2-ylsulfonyl)fluoroacetonitrile 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 为溶剂， 生成 (E)-2-fluoronon-2-enenitrile 、 (Z)-2-fluoronon-2-enenitrile
  参考文献：
  名称：

  Fluoro-Julia Olefination as a Mild, High-Yielding Route to α-Fluoro Acrylonitriles

  摘要：

  Synthesis of a novel, stable reagent (1,3-benzothiazol-2-ylsulfonyl)fluoroacetonitrile from readily synthesized ethyl alpha-(1,3- benzothiazol-2-ylsulfanyl)-alpha-fluoroacetate is reported. Aldehydes undergo condensations with (1,3-benzothiazol-2-ylsulfonyl)fluoroacetonitrile in the presence of DBU leading to alpha-fluoro acrylonitriles in high yields and with good Z-stereoselectivity. Lowering of reaction temperature increases the Z selectivity.

  DOI：

  10.1021/jo801235x

文献信息

• α-Fluoroacrylonitriles: Horner–Wittig synthesis and conversion into 2-fluoroallylamines and C-(1-fluorovinyl)nitrones
  作者：Jan Hein van Steenis、Adrianus M.C.H van den Nieuwendijk、Arne van der Gen

  DOI：10.1016/j.jfluchem.2003.11.001

  日期：2004.1

  alpha-Fluoroacrylonitriles 2 were synthesized in moderate to good yields by Homer-Wittig (HW) reaction of aldehydes and ketones with (diphenylphosphinoyl)fluoroacetonitrile (1), prepared in situ from commercially available fluoroacetonitrile and diphenylphosphinyl chloride. New synthetic applications of 2 are presented with the one-pot conversion into 2-fluoroallylamines 6 and C-(1-fluorovinyl)nitrones 8 through a diisobutylaluminum hydride (DIBALH)-reduction transimination protocol. The scope and limitations of this procedure are discussed. (C) 2003 Elsevier B.V. All rights reserved.
• Xu, Ze-Qi; DesMarteau, Darryl D., Journal of the Chemical Society. Perkin transactions I, 1992, # 3, p. 313 - 316
  作者：Xu, Ze-Qi、DesMarteau, Darryl D.

  DOI：——

  日期：——
• Fluoro-Julia Olefination as a Mild, High-Yielding Route to α-Fluoro Acrylonitriles
  作者：Maria del Solar、Arun K. Ghosh、Barbara Zajc

  DOI：10.1021/jo801235x

  日期：2008.11.7

  Synthesis of a novel, stable reagent (1,3-benzothiazol-2-ylsulfonyl)fluoroacetonitrile from readily synthesized ethyl alpha-(1,3- benzothiazol-2-ylsulfanyl)-alpha-fluoroacetate is reported. Aldehydes undergo condensations with (1,3-benzothiazol-2-ylsulfonyl)fluoroacetonitrile in the presence of DBU leading to alpha-fluoro acrylonitriles in high yields and with good Z-stereoselectivity. Lowering of reaction temperature increases the Z selectivity.