(6-chloroimidazo[1,2-a]pyridin-2-yl)(thien-2-yl)methanone | 1168151-81-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: (6-chloroimidazo[1,2-a]pyridin-2-yl)(thien-2-yl)methanone
• 英文别名: (6-chloroimidazo[1,2-a]pyridin-2-yl)-thiophen-2-ylmethanone
• CAS: 1168151-81-2
• 化学式: C₁₂H₇ClN₂OS
• 分子量: 262.719
• InChiKey: XNEDXVCBVZDQEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-methoxy-N-methyl-6-chloroimidazo[1,2-a]pyridine-2-carboxamide 、 magnesium,2H-thiophen-2-ide,bromide 以 四氢呋喃 为溶剂， 反应 16.0h， 生成 (6-chloroimidazo[1,2-a]pyridin-2-yl)(thien-2-yl)methanone
  参考文献：
  名称：

  2-HETEROAROYLIMIDAZOL[1,2-a]PYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF

  摘要：

  式(I)的化合物： 其中： X，R1，R2，R3和R4如披露中所定义，或其酸盐；其治疗用途。

  公开号：

  US20100317688A1

文献信息

• TREATMENT OF A NEURODEGENERATIVE DISEASE OR DISORDER
  申请人：ACADIA Pharmaceuticals Inc.

  公开号：US20160263189A1

  公开（公告）日：2016-09-15

  Provided herein are methods for treating a neurodegenerative disease or disorder, or stroke using a combination of one or more RXR agonist and/or one or more Nurr1 agonist and one or more trophic factor, or pharmaceutically acceptable salts thereof. Additionally, compositions comprising of one or more RXR agonist and/or one or more Nurr1 agonist and one or more trophic factor, or pharmaceutically acceptable salts thereof for treatment of a neurodegenerative disease or disorder, or stroke are provided.
• [EN] TREATMENT OF A NEURODEGENERATIVE DISEASE OR DISORDER<br/>[FR] TRAITEMENT D'UNE MALADIE OU UN TROUBLE NEURODÉGÉNÉRATIF
  申请人：ACADIA PHARM INC

  公开号：WO2015059632A1

  公开（公告）日：2015-04-30

  Provided herein are methods for treating a neurodegenerative disease or disor- der, or stroke using a combination of one or more RXR agonist and/or one or more Nurr1 agonist and one or more trophic factor, or pharmaceutically acceptable salts thereof. Additionally, compositions comprising of one or more RXR agonist and/or one or more Nurr1 agonist and one or more trophic factor, or pharmaceutically ac- ceptable salts thereof for treatment of a neurodegenerative disease or disorder, or stroke are provided.