(2E,4E)-dodeca-2,4-dien-1-yl isovalerate | 116752-09-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2E,4E)-dodeca-2,4-dien-1-yl isovalerate
• 英文别名: [(2E,4E)-dodeca-2,4-dienyl] 3-methylbutanoate
• CAS: 116752-09-1
• 化学式: C₁₇H₃₀O₂
• 分子量: 266.424
• InChiKey: MZXDKYXUVYNUJK-AQASXUMVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  异戊酰氯 、 2,4-十二碳二烯-1-醇 在 吡啶 作用下， 以 乙醚 为溶剂， 反应 1.5h， 以84%的产率得到(2E,4E)-dodeca-2,4-dien-1-yl isovalerate
  参考文献：
  名称：

  Synthesis of (2E,4E)-dodeca-2,4-dien-1-yl isovalerate, the main component of rootstock oil of Echinacea purpurea

  摘要：

  By phosphine-free Heck reaction a stereoselective synthesis was performed of (2E,4E)-dodeca-2,4-dien-1-yl isovalerate, the main component of the rootstock oil of Echinacea purpurea.

  DOI：

  10.1134/s1070428010020041

文献信息

• [EN] NOVEL E,E-DIENE COMPOUNDS AND THEIR USE AS MEDICAMENTS AND COSMETICS<br/>[FR] NOUVEAUX COMPOSÉS E,E-DIÉNIQUES ET LEUR UTILISATION COMME MÉDICAMENTS ET PRODUITS COSMÉTIQUES
  申请人：WOLFF AUGUST GMBH & CO KG ARZNEIMITTEL DR

  公开号：WO2012069605A1

  公开（公告）日：2012-05-31

  The present invention relates to a novel class of E,E-diene compounds and their use as a medicament, preferably as a dermatologic agent, and as a cosmetic. These novel compounds are particularly useful in treating and/or preventing inflammation, irritation, itching, pruritus, pain, oedema and/or pro-allergic or allergic conditions in a patient. Usually they are topically applied to the skin or mucosa in the form of a pharmaceutical or cosmetic composition comprising the compound and a pharmaceutically and/or cosmetically acceptable carrier.

  本发明涉及一种新型的E,E-二烯化合物及其作为药物的用途，优选作为皮肤科药剂和化妆品。这些新型化合物在治疗和/或预防病人的炎症、刺激、瘙痒、瘙痒、疼痛、水肿和/或过敏或过敏性疾病方面特别有用。通常它们以药用或化妆品组合物的形式局部应用于皮肤或粘膜，该组合物包括该化合物和药学和/或化妆学上可接受的载体。
• Antimicrobial prevention and treatment of human immunedeficience virus and other infectious diseases
  申请人：——

  公开号：US20030104082A1

  公开（公告）日：2003-06-05

  An improved medical treatment and medicine is provided to quickly and safely resolve HIV and other microbial infections. The inexpensive medicine can be self administered and maintained for the prescribed time. The attractive medicine comprises an antimicrobial concentrate comprising microbe inhibitors, phytochemicals or isolates. Desirably, the effective medicine comprises a surfactant and an aqueous carrier or solvent and a nutrient. In the preferred form, the medicine comprises: Echinacea and Commiphora myrrha phytochemicals, benzalkonium chloride, a sterile water solution, and folic acid.

  提供了一种改进的医疗方法和药物，可快速、安全地解决艾滋病毒和其他微生物感染问题。这种药物价格低廉，可自行服用并在规定时间内维持。这种有吸引力的药物包括一种抗微生物浓缩物，其中含有微生物抑制剂、植物化学物质或分离物。理想情况下，有效药物包括表面活性剂和水性载体或溶剂以及营养素。在优选形式中，药物包括紫锥菊和 紫锥菊 植物化学物质、苯扎氯铵、无菌水溶液和叶酸。
• Antimicrobial prevention and treatment of human immunodeficiency virus and other infectious diseases
  申请人：Squires J. Meryl

  公开号：US20060024393A1

  公开（公告）日：2006-02-02

  An improved medical treatment and medicine is provided to quickly and safely resolve HIV and other microbial infections. The inexpensive medicine can be self administered and maintained for the prescribed time. The attractive medicine comprises an antimicrobial concentrate comprising microbe inhibitors, phytochemicals or isolates. Desirably, the effective medicine comprises a surfactant and an aqueous carrier or solvent and a nutrient. In the preferred form, the medicine comprises: Echinacea and Commiphora myrrha phytochemicals, benzalkonium chloride, a sterile water solution, and folic acid.

  提供了一种改进的医疗方法和药物，可快速、安全地解决艾滋病毒和其他微生物感染问题。这种药物价格低廉，可自行服用并在规定时间内维持。这种有吸引力的药物包括一种抗微生物浓缩物，其中含有微生物抑制剂、植物化学物质或分离物。理想情况下，有效药物包括表面活性剂和水性载体或溶剂以及营养素。在优选形式中，药物包括 紫锥菊 和 紫锥菊 植物化学物质、苯扎氯铵、无菌水溶液和叶酸。
• EP0980203A4
  申请人：——

  公开号：EP0980203A4

  公开（公告）日：2004-05-06
• ANTIMICROBIAL PREVENTION AND TREATMENT OF HUMAN IMMUNEDEFICIENCY VIRUS AND OTHER INFECTIOUS DISEASES
  申请人：Squires, Meryl

  公开号：EP0980203A1

  公开（公告）日：2000-02-23