2-高哌啶-1-基丙酸盐酸盐

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-高哌啶-1-基丙酸盐酸盐
• 英文名称: 2-(azepan-1-ium-1-yl)propanoate
• 化学式: C9H17NO2
• mdl: MFCD02674832
• 分子量: 171.24
• InChiKey: PVFHNKAOCOVFKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Highly Selective Novel Amidation Method
  申请人：Inagaki Atsushi

  公开号：US20070238721A1

  公开（公告）日：2007-10-11

  The present invention provides an industrial production method with a short process having a high yield of an aliphatic cyclic carboxamide having carboxyl group, which comprises reacting functional group-selectively using an inexpensive condensing agent without protecting the carboxyl group by esterification, that is, reacting carboxylic acid anhydride obtained by reacting carboxylic acid and tertiary carboxylic acid halide with aliphatic cyclic secondary amine having carboxyl group.

  本发明提供了一种工业生产方法，该方法具有短工艺流程，高产率，用廉价的缩合剂进行功能基选择性反应，不需要通过酯化来保护羧基，即将羧酸和三级羧酸卤化物反应得到羧酸酐，然后与具有羧基的脂环状二级胺反应。
• WRINKLE-PREVENTIVE/AMELIORATING AGENT
  申请人：SHISEIDO COMPANY, LTD.

  公开号：EP1908454A1

  公开（公告）日：2008-04-09

  A wrinkle-preventing and -improving composition comprising one or more than one compound selected from the group consisting of α-amino acid derivatives represented by the following general formula (1) and salts thereof: wherein, R1 represents hydrogen atom, CH3 group or CH2OH group, R2 and R3 each independently represent hydrogen atom, alkyl group having 1 to 4 carbons, provided that R2 and R3 cannot be hydrogen atom at the same time, or R2 and R3 together with N atom to which they are bound may form a ring structure having a total carbon number of 4 to 6, in which case said ring structure may optionally contain an oxygen atom as a heteroatom, R4 represents hydrogen atom, alkyl group having 1 to 18 carbons, wherein when R1 and R4 are hydrogen atom, it cannot be that one of R2 and R3 is benzyloxycarbonyl group and the other is hydrogen atom.

  一种防皱和改善皱纹的组合物，包含一种或一种以上选自下式（1）所代表的 α-氨基酸衍生物及其盐类的化合物： 其中，R1 代表氢原子、CH3 基团或 CH2OH 基团，R2 和 R3 各自独立地代表氢原子、具有 1 至 4 个碳原子的烷基，但 R2 和 R3 不能同时为氢原子，或者 R2 和 R3 与它们所结合的 N 原子可形成一个总碳数为 4 至 6 的环结构、R4 代表氢原子或碳原子数为 1 至 18 的烷基，其中当 R1 和 R4 为氢原子时，R2 和 R3 不能一个为苄氧羰基，另一个为氢原子。
• WRINKLE-PREVENTING AND IMPROVING COMPOSITION
  申请人：TSUNENAGA Makoto

  公开号：US20100168468A1

  公开（公告）日：2010-07-01

  A wrinkle-preventing and -improving composition comprising one or more than one compound selected from the group consisting of α-amino acid derivatives represented by the following general formula (1) and salts thereof: wherein, R 1 represents hydrogen atom, CH 3 group or CH 2 OH group, R 2 and R 3 each independently represent hydrogen atom, alkyl group having 1 to 4 carbons, provided that R 2 and R 3 cannot be hydrogen atom at the same time, or R 2 and R 3 together with N atom to which they are bound may form a ring structure having a total carbon number of 4 to 6, in which case said ring structure may optionally contain an oxygen atom as a heteroatom, R 4 represents hydrogen atom, alkyl group having 1 to 18 carbons, wherein when R 1 and R 4 are hydrogen atom, it cannot be that one of R 2 and R 3 is benzyloxycarbonyl group and the other is hydrogen atom.
• Wrinkle-preventing and improving composition
  申请人：Tsunenaga Makoto

  公开号：US20110065794A1

  公开（公告）日：2011-03-17

  A wrinkle-preventing and -improving composition comprising one or more than one compound selected from the group consisting of α-amino acid derivatives represented by the following general formula (1) and salts thereof: wherein, R 1 represents hydrogen atom, CH 3 group or CH 2 OH group, R 2 and R 3 each independently represent hydrogen atom, alkyl group having 1 to 4 carbons, provided that R 2 and R 3 cannot be hydrogen atom at the same time, or R 2 and R 3 together with N atom to which they are bound may form a ring structure having a total carbon number of 4 to 6, in which case said ring structure may optionally contain an oxygen atom as a heteroatom, R 4 represents hydrogen atom, alkyl group having 1 to 18 carbons, wherein when R 1 and R 4 are hydrogen atom, it cannot be that one of R 2 and R 3 is benzyloxycarbonyl group and the other is hydrogen atom.