甲基2-氮杂双环[2.2.1]庚-5-烯-2-基乙酸酯 | 748093-59-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 甲基2-氮杂双环[2.2.1]庚-5-烯-2-基乙酸酯
• 英文名称: (2-azanorborn-5-en-2-yl)methyl acetate
• 英文别名: N-(2-azanorbornene-5-en)methylacetate；Methyl 2-azabicyclo[2.2.1]hept-5-en-2-ylacetate；methyl 2-(2-azabicyclo[2.2.1]hept-5-en-2-yl)acetate
• CAS: 748093-59-6
• 化学式: C₉H₁₃NO₂
• mdl: MFCD13806375
• 分子量: 167.208
• InChiKey: SJWKUTOHHBSROW-UHFFFAOYSA-N

物化性质

• 沸点：
  236.7±28.0 °C(Predicted)
• 密度：
  1.136±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 甘氨酸甲酯盐酸盐 、 环戊二烯 在 盐酸 作用下， 以 水 为溶剂， 反应 3.0h， 生成 甲基2-氮杂双环[2.2.1]庚-5-烯-2-基乙酸酯
  参考文献：
  名称：

  Polysulfones of new structural types as perspective antioxidant agents

  摘要：

  A series of polysulfones of new structural types on the basis of azanorbornenes, 2,2-diallyl-1,1,3,3-tetraethylguanidiniumchloride and tris(diethylamino)diallylaminophosphonium salts were obtained by free radical polymerization reaction. Their antioxidant properties in lipid peroxidation induced by iron/ascorbate and in erythrocyte hemolysis by H2O2 were evaluated. The polysulfone of 2,2-diallyl-1,1,3,3-tetraethylguanidinium chloride showed protection of erythrocytes against hydrogen peroxide and thermal shock, protected epithelial cells against UV irradiation, was not toxic for erythrocytes, epithelial cells SPEV and 3T3 fibroblasts. The polysulfone of N-benzyl-2-azanorbornene-5 inhibited lipid peroxidation in liver homogenate, did not exhibit cytotoxicity in SPEV and 3T3 cells, protected these against UV irradiation. Both compounds had low bioavailability and may be recommended for further investigations as excipients to be externally applied. (c) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.03.007

文献信息

• US5149825A
  申请人：——

  公开号：US5149825A

  公开（公告）日：1992-09-22
• US5284970A
  申请人：——

  公开号：US5284970A

  公开（公告）日：1994-02-08
• Polysulfones of new structural types as perspective antioxidant agents
  作者：Marina Gorbunova、Lada Anikina

  DOI：10.1016/j.ejmech.2013.03.007

  日期：2013.5

  A series of polysulfones of new structural types on the basis of azanorbornenes, 2,2-diallyl-1,1,3,3-tetraethylguanidiniumchloride and tris(diethylamino)diallylaminophosphonium salts were obtained by free radical polymerization reaction. Their antioxidant properties in lipid peroxidation induced by iron/ascorbate and in erythrocyte hemolysis by H2O2 were evaluated. The polysulfone of 2,2-diallyl-1,1,3,3-tetraethylguanidinium chloride showed protection of erythrocytes against hydrogen peroxide and thermal shock, protected epithelial cells against UV irradiation, was not toxic for erythrocytes, epithelial cells SPEV and 3T3 fibroblasts. The polysulfone of N-benzyl-2-azanorbornene-5 inhibited lipid peroxidation in liver homogenate, did not exhibit cytotoxicity in SPEV and 3T3 cells, protected these against UV irradiation. Both compounds had low bioavailability and may be recommended for further investigations as excipients to be externally applied. (c) 2013 Elsevier Masson SAS. All rights reserved.