4H-thiopyrano[2,3-b]pyridin-4-one | 1207479-33-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4H-thiopyrano[2,3-b]pyridin-4-one
• 英文别名: thiopyrano[2,3-b]pyridin-4-one
• CAS: 1207479-33-1
• 化学式: C₈H₅NOS
• mdl: MFCD18802784
• 分子量: 163.2
• InChiKey: IRHOWPGFPTVHRJ-UHFFFAOYSA-N

物化性质

• 熔点：
  135 °C
• 沸点：
  298.3±40.0 °C(Predicted)
• 密度：
  1.374±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(2-chloropyridin-3-yl)prop-2-yn-1-one 在 sodiumsulfide nonahydrate 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 1.5h， 以101 mg的产率得到4H-thiopyrano[2,3-b]pyridin-4-one
  参考文献：
  名称：

  微波辅助三组分偶联-S N Ar（CASNAR）序列使4 H -thiopyran -4-ones退火†

  摘要：

  微波辅助偶合-S N Ar（CASNAR）序列从容易获得的（杂）芳酰氯开始，以高收率容易地合成了全系列的4 H-硫代吡喃-4-酮作为核心结构单元。炔烃和九水合硫化钠在连续的一锅三组分反应中。所有代表在质子化时均显示出吸收带的明显的光致变色性。根据DFT计算，退火的4 H-硫吡喃-4-酮的电子基态具有相当大的两性离子特征。

  DOI：

  10.1039/b917627f

文献信息

• METHOD OF TREATING AGE-RELATED MACULAR DEGENERATION
  申请人：ZHUHAI QiWEl BIO-TECHNOLOGY LTD.

  公开号：US20220016146A1

  公开（公告）日：2022-01-20

  Provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium . Also provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.
• [EN] ANIMAL MODELS, SCREENING METHODS, AND TREATMENT METHODS FOR INTRAOCULAR DISEASES OR DISORDERS<br/>[FR] MODÈLES D'ANIMAUX, PROCÉDÉS DE CRIBLAGE, ET PROCÉDÉS DE TRAITEMENT POUR MALADIES OU TROUBLES INTRAOCULAIRES
  申请人：ZHUHAI QIWEI BIO TECH LTD

  公开号：WO2020098630A1

  公开（公告）日：2020-05-22

  Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Further provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.
• [EN] METHOD OF TREATING AGE-RELATED MACULAR DEGENERATION<br/>[FR] MÉTHODES DE TRAITEMENT DE LA DÉGÉNÉRESCENCE MACULAIRE LIÉE À L'ÂGE
  申请人：ZHUHAI QIWEI BIO TECH LTD

  公开号：WO2020113759A1

  公开（公告）日：2020-06-11

  Provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Also provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.
• [EN] METHOD OF TREATING AGE-RELATED MACULAR DEGENERATION<br/>[FR] MÉTHODE DE TRAITEMENT DE LA DÉGÉNÉRESCENCE MACULAIRE LIÉE À L'ÂGE
  申请人：ZHUHAI QIWEI BIO TECH LTD

  公开号：WO2020113373A1

  公开（公告）日：2020-06-11

  Provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Also provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.
• Microwave-assisted three-component coupling-addition-S_NAr (CASNAR) sequences to annelated 4H-thiopyran-4-ones
  作者：Benjamin Willy、Walter Frank、Thomas J. J. Müller

  DOI：10.1039/b917627f

  日期：——

  A whole family of annelated 4H-thiopyran-4-ones as the core structural unit was readily synthesized in good yields by a microwave-assisted coupling-addition-SNAr (CASNAR) sequence starting from readily available (het)aroyl chlorides, alkynes and sodium sulfide nonahydrate in a consecutive one-pot three-component reaction. All representatives display a pronounced halochromicity of the absorption bands

  微波辅助偶合-S N Ar（CASNAR）序列从容易获得的（杂）芳酰氯开始，以高收率容易地合成了全系列的4 H-硫代吡喃-4-酮作为核心结构单元。炔烃和九水合硫化钠在连续的一锅三组分反应中。所有代表在质子化时均显示出吸收带的明显的光致变色性。根据DFT计算，退火的4 H-硫吡喃-4-酮的电子基态具有相当大的两性离子特征。