1-[3,5-Bis(4-chlorophenyl)phenyl]-2-(butylamino)ethanol | 781565-17-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[3,5-Bis(4-chlorophenyl)phenyl]-2-(butylamino)ethanol
• CAS: 781565-17-1
• 化学式: C₂₄H₂₅Cl₂NO
• 分子量: 414.375
• InChiKey: IUEQQWAMHXBKSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,5-bis(4-chlorophenyl)styrene 在 间氯过氧苯甲酸 作用下， 以 乙醇 、 氯仿 为溶剂， 反应 8.0h， 生成 1-[3,5-Bis(4-chlorophenyl)phenyl]-2-(butylamino)ethanol
  参考文献：
  名称：

  Antimalarials. 12. Preparation of carbon isosteres of selected 4-pyridinemethanols as suppressive antimalarials

  摘要：

  Four carbon isosteres related to the highly active 4-pyridylcarbinolamines were prepared and evaluated for suppressive antimalarial activity against Plasmodium berghei in mice. Three of the four examples possessed significant activity but were approximately one dose level less active than the corresponding pyridines.

  DOI：

  10.1021/jm00185a009

文献信息

• Antimalarials. 12. Preparation of carbon isosteres of selected 4-pyridinemethanols as suppressive antimalarials
  作者：Anica Markovac、Maurice P. LaMontagne

  DOI：10.1021/jm00185a009

  日期：1980.11

  Four carbon isosteres related to the highly active 4-pyridylcarbinolamines were prepared and evaluated for suppressive antimalarial activity against Plasmodium berghei in mice. Three of the four examples possessed significant activity but were approximately one dose level less active than the corresponding pyridines.