α.α.β-Trimethyl-β-chlor-buttersaeuremethylester | 62886-37-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: α.α.β-Trimethyl-β-chlor-buttersaeuremethylester
• 英文别名: Methyl-3-chlor-2,2,3-trimethylbutanoat；Methyl 3-chloro-2,2,3-trimethylbutanoate；methyl 3-chloro-2,2,3-trimethylbutanoate
• CAS: 62886-37-7
• 化学式: C₈H₁₅ClO₂
• 分子量: 178.659
• InChiKey: KJGWJDNZCPGFHZ-UHFFFAOYSA-N

物化性质

• 沸点：
  193.3±13.0 °C(Predicted)
• 密度：
  1.017±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-methoxy-2,2,3,3-tetramethylcyclopropanol 在 四氯化碳 、 氧气 作用下， 生成 α.α.β-Trimethyl-β-chlor-buttersaeuremethylester
  参考文献：
  名称：

  Free radical reactions of cyclopropanols: The formation of 1,2-dioxolane derivatives

  摘要：

  DOI：

  10.1016/s0040-4039(01)88122-3

文献信息

• Modulators of ATP-binding cassette transporters
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US10022352B2

  公开（公告）日：2018-07-17

  Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

  本发明的化合物及其药学上可接受的组合物可用作 ATP 结合盒（"ABC"）转运体或其片段（包括囊性纤维化跨膜传导调节器（"CFTR"））的调节剂。本发明还涉及使用本发明化合物治疗 ABC 转运体介导的疾病的方法。
• BLOOD-COMPATIBLE FLUORINE-BASED POLYMER AND THIN FILM COMPRISING SAME
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：US20210395424A1

  公开（公告）日：2021-12-23

  Disclosed is a blood-compatible polymer represented by Formula 1. A polymer obtained by grafting a fluorinated methacrylate onto a polyvinylidene fluoride copolymer and provided in one aspect of the present invention is a polymer with blood compatibility, and may provide a blood-compatible material with hydrophobicity. In addition, it is possible to provide a material with controlled contact angle and surface energy properties by controlling the hydrogen fluoride length of the fluorinated methacrylate monomer for modification. Furthermore, it is possible to provide coating with controlled surface properties and blood compatibility through a simple process. Furthermore, it is possible to provide a freestanding polymer film with blood compatibility.
• Free radical reactions of cyclopropanols: The formation of 1,2-dioxolane derivatives
  作者：Dorothy H. Gibson、C.H. DePuy

  DOI：10.1016/s0040-4039(01)88122-3

  日期：——