2H-吡喃-6-甲醛 | 62251-11-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 中文名称: 2H-吡喃-6-甲醛
• 英文名称: Pyralene
• 英文别名: 2H-pyran-6-carbaldehyde
• CAS: 62251-11-0；53025-30-2
• 化学式: C₆H₆O₂
• 分子量: 110.11
• InChiKey: DHQLWKZANUWLGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Azaindole and indolizine derivatives, processes for their production and their use as pharmaceuticals
  申请人：SANDOZ AG

  公开号：EP0265640A2

  公开（公告）日：1988-05-04

  Compounds of Formula I: wherein: either one Y is -N-and the remainder are -CH-X is X1 is with appropriate bond formation, R, is a primary or secondary alkyl, free of asymmetric carbon atoms, R2 is a substituted or unsubstituted phenyl, primary or secondary C1-6 alkyl, free of asymmetric carbon atoms, C3.6 cycloalkyl or phenylakyl as defined in the specification, A is or b) -(CH2)n- wherein n is 1,2 or 3 Z is in which R8 is hydrogen, R9 or M wherein R9 is a physiologically acceptable and hydrolysable ester group, and M is a pharmaceutically acceptable cation; or: each Y is -CH-, X is -N-, X1 is with appropriate bond formation, R, and R2 are independently as defined under R2 above and R2 may additionally be hydrogen A and Z are as defined above are obtained by multi-step processes and are useful as hypolipoproteinemic and anti-atherosclerotic agents.

  式 I 的化合物： 其中 其中一个 Y 是-N，其余为-CH-X 是 X1 是 与适当的键形成、 R是伯或仲烷基，不含不对称碳原子、 R2 是取代或未取代的苯基、不含不对称碳原子的伯或仲 C1-6 烷基、C3.6 环烷基或说明书中定义的苯基、 A 是 或 b) -(CH2)n- 其中 n 为 1、2 或 3 Z 为 其中 R8 是氢、R9 或 M，其中 R9 是生理上可接受的可水解的酯基，而 M 是药学上可接受的阳离子；或：每个 Y 是-CH-，X 是-N-，X1 是-CH-，X2 是-CH2-，X3 是-CH2-，X4 是-CH2-，X5 是-CH2-。 与适当的键形成、 R 和 R2 独立地如上文 R2 中所定义，R2 还可以是氢 A 和 Z 如上所定义 通过多步工艺获得，可用作降脂蛋白血症和抗动脉粥样硬化药物。
• COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US20210289794A1

  公开（公告）日：2021-09-23

  The invention comprises methods for decreasing colonization by a bacterium of a gut of a stink bug, the method comprising providing a composition comprising vanillin or an analog thereof; and delivering said composition to an egg from which the stink bug will hatch, whereby colonization by the bacterium within the gut of the stink bug hatched from the egg treated with the composition is decreased relative to a stink bug hatched from an untreated egg. In some embodiments, the decrease in colonization by the bacterium decreases the fitness of the stink bug, e.g., decreases reproductive ability, survival, rate of development, number of eggs, number of hatched eggs, adult emergence rate, body length, body width, body mass, or cuticle thickness. In some embodiments of the methods herein, the bacterial colonization-disrupting agent is an inhibitor of bacterial metabolism. In some embodiments, the bacterial colonization-disrupting agent is a polyhydroxyalkanoate (PHA) synthesis inhibitor.
• US4344956A
  申请人：——

  公开号：US4344956A

  公开（公告）日：1982-08-17