2H-四唑-2-乙酸 | 21743-64-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2H-四唑-2-乙酸
• 英文名称: 2H-tetrazol-2-ylacetic acid
• 英文别名: 2H-tetrazolylacetic acid；tetrazol-2-ylacetic acid；2-Tetrazolylacetic Acid；tetrazole-1-acetic acid；2-TzaH；tetrazol-2-yl-acetic acid；2H-Tetrazol-2-acetic acid；2-(tetrazol-2-yl)acetic acid
• CAS: 21743-64-6
• 化学式: C₃H₄N₄O₂
• mdl: MFCD00461719
• 分子量: 128.09
• InChiKey: ZYHXBGMQUWRUBE-UHFFFAOYSA-N

物化性质

• 沸点：
  381.1±44.0 °C(Predicted)
• 密度：
  1.78±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  80.9
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  2H-四唑-2-乙酸 生成 (S)-2-Oxo-3-[(2H-tetrazol-2-ylacetyl)amino]-1-azetidinesulfonic acid, potassium salt
  参考文献：
  名称：

  2-oxo-1-azetidinesulfonic acid salts

  摘要：

  具有磺酸盐取代基位于1位和氨基或酰胺基取代基位于3位的β-内酰胺类化合物具有抗菌活性。

  公开号：

  US04775670A1
• 作为产物：
  描述：

  四氮唑 、 溴乙酸乙酯 生成 2H-四唑-2-乙酸
  参考文献：
  名称：

  Preparation and characterization of the first coordination compounds of tetrazol-2-ylacetic acid

  摘要：

  Tetrazol-2-ylacetic acid (2-TzaH) was found to react with CuCl2, PdCl2, and K2PtCl4 in water giving Cu(2-Tza)(2), PdCl2(2-TzaH)(2)center dot 2H(2)O and PtCl2(2-TzaH)(2), correspondingly. Obtained complexes, being the first reported examples of coordination compounds derived from 2-TzaH, have been characterized by IR spectroscopy, thermal and X-ray diffraction methods. 2-TzaH was found to act as a monodentate ligand coordinated to the metal ion via N4 atom of heteroring in palladium complex and as tridentate bridging ligand coordinated via N4 atom and two oxygen atoms in copper complex. Cu(2-Tza)(2) presents 2D coordination polymer, whereas PdCl2(2-TzaH)(2)center dot 2H(2)O is molecular complex. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2010.05.003

文献信息

• [EN] 7-OXO -6-(SULFOOXY)- 1,6-DIAZABICYCLO [3.2.1] OCTANE CONTAINING COMPOUNDS AND THEIR USE IN TREATMENT OF BACTERIAL INFECTIONS<br/>[FR] 7-OXO-6-(SULFOOXY)-1,6-DIAZABICYCLO[3.2.1] OCTANE CONTENANT DES COMPOSÉS ET LEUR UTILISATION DANS LE TRAITEMENT D'INFECTIONS BACTÉRIENNES
  申请人：WOCKHARDT LTD

  公开号：WO2017081615A1

  公开（公告）日：2017-05-18

  Compounds of Formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, their preparation, and use in treating a bacterial infection are disclosed.

  化合物的公式（I）或其立体异构体或药学上可接受的盐，其制备以及在治疗细菌感染中的用途被披露。
• ARYL DIHYDROPYRIDINONE AND PIPERIDINONE MGAT2 INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：US20130143843A1

  公开（公告）日：2013-06-06

  The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.

  本发明提供了式（I）的化合物：或其立体异构体或药学上可接受的盐，其中所有变量如本文中所定义。这些化合物是单酰基甘油酰基转移酶2（MGAT2）抑制剂，可用作药物。
• Aryl dihydropyridinone and piperidinone MGAT2 inhibitors
  申请人：Bristol-Myers Squibb Company

  公开号：US08791091B2

  公开（公告）日：2014-07-29

  The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.

  本发明提供了式（I）的化合物：或其立体异构体，或其药学上可接受的盐，其中所有变量如本文所定义。这些化合物是单酰基甘油酰基转移酶2（MGAT2）抑制剂，可用作药物。
• ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：US20150315144A1

  公开（公告）日：2015-11-05

  The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.

  本发明提供了式（I）的化合物：或其立体异构体，或其药学上可接受的盐，其中所有变量均如定义所述。这些化合物是单酰基甘油酰转移酶2（MGAT2）抑制剂，可用作药物。
• Antibacterial activity of 6-(5-membered heteroarylacetamido)penicillanic acids
  作者：Ronald G. Micetich、Rintje Raap、John Howard、Imre Pushkas

  DOI：10.1021/jm00273a033

  日期：1972.3