5-deoxy-1,4:3,6-dianhydro-D-glucitol | 139402-86-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃类
• 英文名称: 5-deoxy-1,4:3,6-dianhydro-D-glucitol
• 英文别名: (3aR,6S,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-ol
• CAS: 139402-86-1
• 化学式: C₆H₁₀O₃
• 分子量: 130.144
• InChiKey: UBVWYDZEQJSKOY-KVQBGUIXSA-N

物化性质

• 沸点：
  265.2±20.0 °C(Predicted)
• 密度：
  1.275±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  对甲苯磺酰氯 、 5-deoxy-1,4:3,6-dianhydro-D-glucitol 在 吡啶 作用下， 反应 29.0h， 以86%的产率得到2-O-tosyl-5-deoxy-1,4:3,6-dianhydro-D-glucitol
  参考文献：
  名称：

  Novel isonucleoside analogues: synthesis of 2′-deoxy-2′-nucleobase-5′-deoxy-1′,4′-anhydro-d-altritol

  摘要：

  A new class of isonucleoside analogues with branched-sugar 2'-deoxy-2'-nucleobase-5'-deoxy-1',4'-anhydro-D-altritol (21, 23a-c) has been synthesized from D-glucose in Il steps. The construction of branched-chain sugars has been carried out by hydroboration-oxidation of a double bond in the corresponding hexose. The key intermediate 12 was synthesized from the branched-chain sugar 11 by the reductive cleavage reaction in the presence of TMSOTf and triethylsilane. A strong solvent effect was observed in the intramolecular nucleophilic substitution of 12. The protic solvent is favorable to form the bicyclic compound 18 by double S(N)2 substitution. The opening reaction of epoxide 17 by nucleobases was achieved regioselectively to give the desired isonucleosides in reasonable yield. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00136-1
• 作为产物：
  描述：

  5-deoxy-1,2-O-isopropylidene-3-O-p-tolylsulfonyl-α-D-xylo-hexofuranose 在 吡啶 、 三氟甲磺酸三甲基硅酯 、 potassium tert-butylate 作用下， 以 四氢呋喃 、 二氯甲烷 、 叔丁醇 为溶剂， 反应 67.5h， 生成 5-deoxy-1,4:3,6-dianhydro-D-glucitol
  参考文献：
  名称：

  Novel isonucleoside analogues: synthesis of 2′-deoxy-2′-nucleobase-5′-deoxy-1′,4′-anhydro-d-altritol

  摘要：

  A new class of isonucleoside analogues with branched-sugar 2'-deoxy-2'-nucleobase-5'-deoxy-1',4'-anhydro-D-altritol (21, 23a-c) has been synthesized from D-glucose in Il steps. The construction of branched-chain sugars has been carried out by hydroboration-oxidation of a double bond in the corresponding hexose. The key intermediate 12 was synthesized from the branched-chain sugar 11 by the reductive cleavage reaction in the presence of TMSOTf and triethylsilane. A strong solvent effect was observed in the intramolecular nucleophilic substitution of 12. The protic solvent is favorable to form the bicyclic compound 18 by double S(N)2 substitution. The opening reaction of epoxide 17 by nucleobases was achieved regioselectively to give the desired isonucleosides in reasonable yield. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00136-1

文献信息

• FLAME-RETARDANT POLYCARBONATE RESIN COMPOSITION
  申请人：Teijin Limited

  公开号：EP2154199A1

  公开（公告）日：2010-02-17

  There is provided a resin composition that comprises a polycarbonate resin derived from an ether diol such as isosorbide and that is excellent in flame retardancy, heat resistance, thermal stability, rigidity, transparency and moldability. The resin composition is a flame-retardant resin composition comprising 1 to 60 parts by weight of phosphorus compound (component B) having a thermal decomposition temperature of not higher than 340°C based on 100 parts by weight of polycarbonate resin (component A) that mainly comprises a recurring unit represented by the following formula (1).

  本发明提供了一种树脂组合物，该树脂组合物包含由醚二醇（如异山梨醇）衍生的聚碳酸酯树脂，该树脂组合物具有优异的阻燃性、耐热性、热稳定性、刚性、透明度和成型性。 该树脂组合物是一种阻燃性树脂组合物，它包含 1 至 60 份（按重量计）磷化合物（B 组分），以 100 份（按重量计）聚碳酸酯树脂（A 组分）为基准，其热分解温度不高于 340°C，该树脂组合物主要包含由下式（1）表示的循环单元。
• POLYMERES TRIAZOLES/TETRAZOLES ISSUS DE LA CYCLO ADDITION DE MONOMERES DERIVES DE DIANHYDROHEXITOL FONCTIONNALISES, COMPOSES INTERMEDIAIRES, LEURS PROCEDES DE PREPARATION ET LEURS APPLICATIONS
  申请人：Roquette Frères

  公开号：EP2430027B1

  公开（公告）日：2016-02-10
• INK COMPOSITION
  申请人：OCE-Technologies B.V.

  公开号：EP2964711B1

  公开（公告）日：2017-05-10
• LIQUID CRYSTALLINE MEDIUM AND LIQUID CRYSTAL DISPLAY
  申请人：Merck Patent GmbH

  公开号：US20150329782A1

  公开（公告）日：2015-11-19

  The instant invention relates to liquid crystalline media comprising a chiral component, component A, consisting of one or more chiral compounds, optionally, a bimesogenic component, component B, consisting of one or more bimesogenic compounds, a liquid crystalline component, component C, consisting of one or more liquid crystalline, respectively mesogenic compounds, and a reactive mesogenic component, component D, comprising, one or more reactive mesogenic compounds, as defined in claim 1 , to their stabilization by polymerization and to the polymer-stabilised liquid crystal materials, as well as to liquid crystal displays comprising these liquid crystal media, respectively these stabilized materials, especially to USH-displays and in particular to active matrix displays and, last not least, to the processes of preparation of the respective composite systems and of the displays comprising these systems.
• ISOIDIDE DERIVATIVES AND METHODS OF MAKING AND USING SAME
  申请人：RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

  公开号：US20210002291A1

  公开（公告）日：2021-01-07

  The present disclosure relates to compounds having an improved solubility thereby increasing their bioavailability, lower dosages, etc. The target compounds, may include but are not limited to, macrophage migration inhibitory factor (MIF) inhibitors, epidermal growth factor receptor (EGRF) inhibitors, kinase inhibitors and prodrugs of alpha4 beta1 and alpha4 beta7 integrin antagonists. An illustrative compound is shown below: