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13H-dibenzo[a,g]fluorene | 207-83-0

中文名称
——
中文别名
——
英文名称
13H-dibenzo[a,g]fluorene
英文别名
dibenzo[c,h]fluorene;13H-dibenzofluorene;dibenzo[a,g]fluorene;13H-Dibenzo[a,g]fluoren;13H-DIBENZO(a,g)FLUORENE;pentacyclo[11.8.0.02,11.03,8.014,19]henicosa-1(13),2(11),3,5,7,9,14,16,18,20-decaene
13H-dibenzo[a,g]fluorene化学式
CAS
207-83-0
化学式
C21H14
mdl
——
分子量
266.342
InChiKey
QEHKXCNHQCUFRW-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 熔点:
    174.5°C
  • 沸点:
    344.54°C (rough estimate)
  • 密度:
    1.1340 (estimate)

计算性质

  • 辛醇/水分配系数(LogP):
    6.9
  • 重原子数:
    21
  • 可旋转键数:
    0
  • 环数:
    5.0
  • sp3杂化的碳原子比例:
    0.05
  • 拓扑面积:
    0
  • 氢给体数:
    0
  • 氢受体数:
    0

ADMET

毒理性
  • 致癌物分类
国际癌症研究机构致癌物:13H-二苯并[a,g]芴
IARC Carcinogenic Agent:13H-Dibenzo[a,g]fluorene
来源:International Agency for Research on Cancer (IARC)
毒理性
  • 致癌物分类
国际癌症研究机构(IARC)致癌物分类:第3组:无法归类其对人类致癌性
IARC Carcinogenic Classes:Group 3: Not classifiable as to its carcinogenicity to humans
来源:International Agency for Research on Cancer (IARC)
毒理性
  • 致癌物分类
国际癌症研究机构专著:第92卷:(2010年)一些非杂环多环芳烃及其相关暴露
IARC Monographs:Volume 92: (2010) Some Non-heterocyclic Polycyclic Aromatic Hydrocarbons and Some Related Exposures
来源:International Agency for Research on Cancer (IARC)

安全信息

  • 海关编码:
    2902909090

SDS

SDS:d4f09cf0a463dbcc7d0f6e527d1f0db4
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上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    13H-dibenzo[a,g]fluorenebismuth(III) nitrate 作用下, 反应 0.03h, 以90%的产率得到11-nitro-13H-dibenzofluorene
    参考文献:
    名称:
    Microwave-Induced Surface-Mediated Highly Efficient Regioselective Nitration of Aromatic Compounds: Effects of Penetration Depth
    摘要:
    本研究调查了在不同微波诱导条件下芳香化合物的表面介导高度区域选择性硝化。发现表面的穿透深度对反应的影响比其他介电参数更为关键。尽管微波诱导反应取得了显著进展,但没有报告研究过这些过程中使用的表面的穿透深度。
    DOI:
    10.14233/ajchem.2021.23131
  • 作为产物:
    描述:
    3-naphthalen-2-yl-2-phenyl-propionic acid氢氧化钾selenium一水合肼 作用下, 以 乙二醇 为溶剂, 反应 4.0h, 生成 13H-dibenzo[a,g]fluorene
    参考文献:
    名称:
    780.多环化合物的合成。第七部分 茚并(2',3'-1,2)菲及其类似物的更短途径
    摘要:
    DOI:
    10.1039/jr9620003974
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文献信息

  • Antitumor dibenzofluorene derivatives
    申请人:Board of Regents, The University of Texas System
    公开号:US06362200B1
    公开(公告)日:2002-03-26
    Dibenzofluorene derivatives having a formula selected from the group consisting of and salts thereof have antitumor activity. At least one of R1-R13 in formula (I) or R1-R12 in formula (II) is —R14Z. R14 is a substituted or unsubstituted amino or amido group having from 1-12 carbon atoms, and Z is a substituted or unsubstituted heterocyclic group having from 1-12 carbon atoms. The remainder of R1-R13 in formula (I) or R1-R12 in formula (II) are independently selected from the group consisting of hydrogen, hydroxyl, halogen, nitro, substituted or unsubstituted amino or amido groups having from 1-12 carbon atoms, and alkyl groups having 1-12 carbon atoms.
    二苯并芴衍生物具有以下组成的公式,其盐具有抗肿瘤活性。在公式(I)中的R1-R13中的至少一个或在公式(II)中的R1-R12中的至少一个是—R14Z。其中,R14是具有1-12个碳原子的取代或未取代氨基或酰胺基团,Z是具有1-12个碳原子的取代或未取代杂环基团。在公式(I)中的R1-R13的其余部分或在公式(II)中的R1-R12是独立地从氢、羟基、卤素、硝基、具有1-12个碳原子的取代或未取代氨基或酰胺基团以及具有1-12个碳原子的烷基基团的组成中选择的。
  • East Timor and the new humanitarian interventionism
    作者:Nicholas J. Wheeler、Tim Dunne
    DOI:10.1111/1468-2346.00220
    日期:2001.10
    The fate of East Timor provides a barometer for how far the normative structure of international society has been transformed since the end of the Cold War. In 1975, the East Timorese were abandoned by a Western bloc that placed accommodating the Indonesian invasion of the island before the protection of human rights. Twenty-five years later, it was the protection of the civilian population on the island that loomed large in the calculations of these same states. Australia, which had sacrificed the rights of the people of East Timor on the altar of good relations with Indonesia, found itself leading an intervention force that challenged the old certainties of its ‘Jakarta first’ policy. The article charts the interplay of domestic and international factors that made this normative transformation possible. The authors examine the political and economic factors that led to the agreement in May 1999 between Portugal, Indonesia and the UN to hold a referendum on the future political status of East Timor. A key question is whether the international community should have done more to assure the security of the ballot process. The authors argue that while more could have been done by Australia, the United States and officials in the UN Secretariat to place this issue on the Security Council's agenda, it is highly unlikely that the international community would have proved capable of mobilizing the political will necessary to coerce Indonesia into accepting a peacekeeping force.The second part of the article looks at how the outbreak of the violence in early September 1999 fundamentally changed these political assumptions. The authors argue that it became politically possible to employ coercion against Indonesian sovereignty in a context in which the Habibie government was viewed as having failed to exercise sovereignty with responsibility. By focusing on the economic and military sanctions employed by Western states, the pressures exerted by the international financial institutions and the intense diplomatic activity at the UN and in Jakarta, the authors show how Indonesian political and military leaders were prevailed upon to accept an international force. At the same time, Australian reporting of the atrocities and how this prompted the Howard government to an intervention that challenged traditional conceptionsof Australia's vital interests, is considered. The conclusion reflects on how thiscase supports the claim that traditional notions of sovereignty are increasinglyconstrained by norms of humanitarian responsibility.
    东帝汶的命运为冷战刚刚结束以来国际社会的规范结构发生了多大的改变提供了晴雨表。1975年,东帝汶遭到了西方阵营的抛弃.该阵营把容忍印度尼西亚对东帝汶的入侵放在了保护人权之前。二十五年后,保护该岛平民成为这些国家最关心的事。曾经牺牲东帝汶人民权利并以此换取与印度尼西亚良好关系的澳大利亚发现自己正领导一支干预力量,对本国“雅加达优先”政策的老传统提出了挑战。本文着重描述了使得这一规范转变成为可能的国内外因素之间的相互作用。作者们探讨了导致1999年5月葡萄牙、印度尼西亚与联合国达成在东帝汶举行关于未来政治地位的全民公决协议的政治与经济因素。一个关键问题是,国际社会是否本应采取更多的行动来确保全民公决过程的安全。作者们认为,尽管澳大利亚、美国与联合国秘书处的官员们本可以采取更多的行动把这一问题放在联合国安理会的议程表上,但是国际社会已经不可能具有动员必要的政治意愿来迫使印度尼西亚接受一支维和部队的能力了。 本文的第二部分研究了1999年9月初爆发的暴力是怎样从根本改变了这些政治假定的。作者们认为,如果将哈比比政府视为一个没有负责任地使用主权的政府,那么在这样的情形下,对印度尼西的主权使用强制就是政治上可能的。作者们将重点放在为了迫使印度尼西亚接受一支国际部队,西方国家所实施的经济与军事制裁、国际金融机构施加的压力,以及联合国和雅加达的紧张外交活动。同时,还考虑到澳大利亚有关暴行的报道是怎样促使霍华德发动了这场干预行动的,这场干预行动挑战了澳大利亚关键利益的旧有传统观念。结论部分就这一事例如何支持如下主张进行了思考:传统的主权观念由于人道主义责任的规范而日益受到制约。
  • AMINODIBENZOFLUORENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME
    申请人:TAKASHIMA Yoriyuki
    公开号:US20090267491A1
    公开(公告)日:2009-10-29
    A novel compound which is useful as a constitutional component for an organic EL device is provided by an aminodibenzofluorene derivative comprising (A) at least one dibenzofluorene structure and (B) at least one amino group in a molecule, a material for an organic electroluminescence (EL) device comprising the same, a light emitting material for an organic EL device, a light emitting organic solution, an organic EL device in which an organic compound layer comprising a single layer or plural layers including at least a light emitting layer is interposed between a pair of electrodes, wherein at leas one layer in the organic compound layer described above contains at least one kind of the aminodibenzofluorene derivative described above and an equipment comprising the same. A practical organic EL device which has a low operating voltage, a long lifetime and a high current efficiency and which provides blue light emission having an excellent color purity is materialized by using the above compound.
    提供了一种新型化合物,可作为有机EL器件的构成组分,该化合物由包含(A)至少一个二苯并芴结构和(B)至少一个氨基团的氨基二苯并芴衍生物组成,一种用于有机电致发光(EL)器件的材料,一种用于有机EL器件的发光材料,一种发光有机溶液,一种有机EL器件,其中在一对电极之间夹设了包括至少一个发光层的单层或多层的有机化合物层,上述有机化合物层中的至少一层含有上述氨基二苯并芴衍生物中的至少一种,以及包括该化合物的设备。通过使用上述化合物,可以实现具有低工作电压、长寿命和高电流效率的实用有机EL器件,并提供具有优异色纯度的蓝光发射。
  • An Efficient Synthesis of Benzofluorenes Via α-Alkoxycarbonyldiarylmethyl Cations
    作者:A. C. Hopkinson、E. Lee-Ruff、M. Maleki
    DOI:10.1055/s-1986-31637
    日期:——
    Rearrangements of α-alkoxycarbonyldiarylmethyl cations lead to 9-fluorenecarboxylic esters. Decarboxylation of these esters generates the fluorene derivatives 9a-f. The precursors to the cations are the α-hydroxyesters 6a-g.This conversion constitutes a facile synthesis of benzofluorenes.
    α-烷氧基羧基二芳基甲基阳离子的重排导致9-芴酸酯的生成。这些酯的脱羧反应生成氟烯衍生物9a-f。这些阳离子的前驱体是α-羟基酯6a-g。这一转化构成了苯并芴类化合物的简便合成。
  • Stereocontrolled synthesis of anticancer β-lactams via the Staudinger reaction
    作者:Bimal K. Banik、Indrani Banik、Frederick F. Becker
    DOI:10.1016/j.bmc.2005.03.044
    日期:2005.6
    Stereocontrolled synthesis of novel beta-lactams using polyaromatic imines following the Staudinger reaction has been accomplished. The effects of domestic microwave irradiation on this type of reaction have been investigated. Formation of trans-beta-lactams has been explained through isomerization of the enolates formed during the reaction of acid chloride (equivalent) with imines in the presence
    在施陶丁格反应之后,已经完成了使用聚芳族亚胺的立体控制合成新的β-内酰胺的方法。已经研究了家用微波辐射对这种类型的反应的影响。通过在三乙胺存在下酰氯(当量)与亚胺反应期间形成的烯醇化物的异构化,可以解释反式β-内酰胺的形成。据信供体-受体复合物途径与顺-β-内酰胺的形成有关。已经发现,在控制所得β-内酰胺的立体化学中,氢的作用显着。SAR已鉴定出具有抗癌活性的β-内酰胺。乙酰氧基的存在已被证明对于其抗癌活性是必不可少的。
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