(S)-1-(4-chlorophenyl)-1-cyclopropyl-methanol | 918410-66-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-1-(4-chlorophenyl)-1-cyclopropyl-methanol
• 英文别名: (4-chlorophenyl)cyclopropylmethanol；(S)-(4-chlorophenyl)-cyclopropylmethanol
• CAS: 918410-66-9
• 化学式: C₁₀H₁₁ClO
• 分子量: 182.65
• InChiKey: CLKPSDBTSRWVOQ-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-氯-alpha-氯丙基苄醇 在 葡萄糖 作用下， 以 乙醇 、 正己烷 、 水 、 烯丙醇 为溶剂， 反应 216.0h， 生成 (S)-1-(4-chlorophenyl)-1-cyclopropyl-methanol
  参考文献：
  名称：

  Asymmetric preparation of antifungal 1-(4′-chlorophenyl)-1-cyclopropyl methanol and 1-(4′-chlorophenyl)-2-phenylethanol. Study of the detoxification mechanism by Botrytis cinerea

  摘要：

  Chiral alcohols are important as bioactive compounds or as precursors to such molecules. On the basis of the different antifungal properties of the enantiopure alcohol derivatives of 4'-chlorophenyl cyclopropyl ketone and benzyl 4'-chlorophenyl ketone, their enantioselective synthesis by chemical and biocatalytic methods was studied. The detoxification pathways by the phytopathogen fungus Bonytis cinerea are reported. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcatb.2011.02.005

文献信息

• Copper-dipyridylphosphine-catalyzed hydrosilylation: enantioselective synthesis of aryl- and heteroarylcycloalkyl alcohols
  作者：Shan-Bin Qi、Min Li、Shijun Li、Ji-Ning Zhou、Jun-Wen Wu、Feng Yu、Xi-Chang Zhang、Albert S. C. Chan、Jing Wu

  DOI：10.1039/c2ob27040d

  日期：——

  hydrosilylation of a vast array of aryl cycloalkyl ketones with different ring sizes was studied systematically for the first time (up to 99% enantiomeric excess). The results demonstrated that the steric size of cycloalkyl groups has a significant influence on the reaction outcomes. The first stereoselective formation of a selection of cyclohexyl heteroaryl alcohols of up to 97% enantiopurity was realized

  首次系统地研究了非贵金属铜催化的各种不同环尺寸的芳基环烷基酮的对映选择性氢化硅烷化（对映体过量高达99％）。结果表明，环烷基的空间大小对反应结果有重要影响。还实现了对映体纯度高达97％的环己基杂芳基醇的选择的首次立体选择性形成。在某些环己基吡啶基酮的还原中，观察到温度对醇产物的对映体纯度和绝对构型都有显着影响。