2-(2-chloro-5-tosylphenyl)pyridine | 1571059-99-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(2-chloro-5-tosylphenyl)pyridine
• 英文别名: 2-[2-Chloro-5-(4-methylphenyl)sulfonylphenyl]pyridine；2-[2-chloro-5-(4-methylphenyl)sulfonylphenyl]pyridine
• CAS: 1571059-99-8
• 化学式: C₁₈H₁₄ClNO₂S
• 分子量: 343.834
• InChiKey: UFIOOPCNTUEYFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(3-tosylphenyl)pyridine 在 六氯乙烷 、 copper diacetate 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以67%的产率得到2-(2-chloro-5-tosylphenyl)pyridine
  参考文献：
  名称：

  Sequential Chelation-Assisted Aromatic C–H Functionalisation via Catalytic meta Sulfonation

  摘要：

  The sequential functionalisation of 2-phenylpyridine is presented using selective ortho- and meta-directing processes. It was found that performing a reaction sequence with meta functionalisation first followed by ortho functionalisation provided novel reaction products in good yields and with complete regioselectivity.

  DOI：

  10.1055/s-0033-1340011

文献信息

• Sequential Chelation-Assisted Aromatic C–H Functionalisation via Catalytic meta Sulfonation
  作者：Christopher Frost、William Reynolds、Po Liu、Gabriele Kociok-Köhn

  DOI：10.1055/s-0033-1340011

  日期：——

  The sequential functionalisation of 2-phenylpyridine is presented using selective ortho- and meta-directing processes. It was found that performing a reaction sequence with meta functionalisation first followed by ortho functionalisation provided novel reaction products in good yields and with complete regioselectivity.