2-[3-(benzhydrylideneamino)propyl]isoindole-1,3-dione | 1223557-72-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[3-(benzhydrylideneamino)propyl]isoindole-1,3-dione
• CAS: 1223557-72-9
• 化学式: C₂₄H₂₀N₂O₂
• 分子量: 368.435
• InChiKey: IASDQWSDMMBIPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  49.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(3-碘丙基)-1H-异吲哚-1,3(2H)-二酮 、 N-trimethylstannyl benzophenone imine 在 二叔丁基过氧化物 作用下， 以 正庚烷 为溶剂， 反应 24.0h， 以77%的产率得到2-[3-(benzhydrylideneamino)propyl]isoindole-1,3-dione
  参考文献：
  名称：

  Radical Amination with Trimethylstannylated Benzophenone Imine

  摘要：

  Intermolecular radical amination reactions of various primary, secondary, and tertiary alkyl radicals by using trimethylstannylated benzophenone imine A as a novel radical acceptor to provide imines of type B are described. These Imines are readily reduced with NaBH4 to the corresponding secondary amines C. The novel radical amination can be combined with typical radical cyclization reactions.

  DOI：

  10.1021/ol1005455

文献信息

• Radical Amination with Trimethylstannylated Benzophenone Imine
  作者：Marie-Céline Lamas、Santiago E. Vaillard、Birgit Wibbeling、Armido Studer

  DOI：10.1021/ol1005455

  日期：2010.5.7

  Intermolecular radical amination reactions of various primary, secondary, and tertiary alkyl radicals by using trimethylstannylated benzophenone imine A as a novel radical acceptor to provide imines of type B are described. These Imines are readily reduced with NaBH4 to the corresponding secondary amines C. The novel radical amination can be combined with typical radical cyclization reactions.