tert-butyl 2-(N-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-3-phenylmethoxyanilino)acetate | 199165-91-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl 2-(N-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-3-phenylmethoxyanilino)acetate
• CAS: 199165-91-8
• 化学式: C₂₅H₃₃NO₅
• 分子量: 427.541
• InChiKey: KQUIZHOBKZTNOR-UHFFFAOYSA-N

物化性质

• 沸点：
  522.6±45.0 °C(Predicted)
• 密度：
  1.112±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  31
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  65.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  tert-butyl 2-(N-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-3-phenylmethoxyanilino)acetate 在 palladium on activated charcoal 环己烯 作用下， 以 乙醇 、 甲苯 、 正丁醇 为溶剂， 生成
  参考文献：
  名称：

  Chemosensing in deep red: A squaraine-based fluorescent chemosensor for pH

  摘要：

  We have synthesized and spectrally characterized a squaraine-based fluorescent chemosensor for pH. This chemosensor unlike many others, works in 100 % aqueous solutions, signalling the pH change from 10 to 7 by a 11-fold increase in the emission intensity at 651 nm, when excited at the isosbestic point (614 nm). The average pK(a) for the ionizable groups is found to be 8.8. The chemosensor with its molar extinction coefficient > 200,000 and the quantum yield of 0.2, yield an impressive intrinsic brightness value of 40,000. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)01745-0
• 作为产物：
  描述：

  溴乙酸叔丁酯 、 3-苄氧基苯胺 在 1,8-双二甲氨基萘 作用下， 以 乙腈 为溶剂， 反应 25.0h， 以72%的产率得到tert-butyl 2-(N-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-3-phenylmethoxyanilino)acetate
  参考文献：
  名称：

  Efficient detection of polycyclic aromatic hydrocarbons and polychlorinated biphenyls via three-component energy transfer

  摘要：

  本文报告的是通过近距离诱导的非共价能量转移检测剧毒多环芳烃（PAHs）和多氯联苯（PCBs）的方法。这种能量转移发生在 γ-环糊精的空腔中，即使对毒性最强的多环芳烃和荧光最少的多氯联苯也有效。利用基于阵列的系统进行选择性检测的低检测限和潜力，再加上简单的实验设置，使这种新的检测方法特别有前途。

  DOI：

  10.1039/c3cc40534f

文献信息

• Fluorescent Sensor and Methods
  申请人：Snee Preston T.

  公开号：US20120094390A1

  公开（公告）日：2012-04-19

  Binding an analyte can cause a change in fluorescence emission of a sensor. The change in fluorescence can be related to the amount of analyte present. The sensor can include a semiconductor nanocrystal linked to a fluorescent moiety. Upon excitation, the fluorescent moiety can transfer energy to the semiconductor nanocrystal, or vice versa.

  分析物的结合可以导致传感器的荧光发射发生变化。荧光的变化可以与分析物的数量相关。传感器可以包括与荧光基团相连的半导体纳米晶体。在激发时，荧光基团可以将能量转移到半导体纳米晶体，反之亦然。
• A Ratiometric CdSe/ZnS Nanocrystal pH Sensor
  作者：Preston T. Snee、Rebecca C. Somers、Gautham Nair、John P. Zimmer、Moungi G. Bawendi、Daniel G. Nocera

  DOI：10.1021/ja0618999

  日期：2006.10.1

  The development of a reversible chemical sensor based on a CdSe/ZnS nanocrystal (NC) is described. Signal transduction is accomplished by fluorescence resonance energy transfer (FRET) between the NC and a fluorescent pH-sensitive squaraine dye attached to the surface of the NC. The efficiency of FRET, and consequently the relative intensity of NC and dye emissions, is modulated with the pH-dependent absorption cross section of the squaraine dye. The design of a NC sensor based on FRET results in a ratiometric sensor since the emission intensities of dye and NC may be referenced to the isosbestic point between NC and dye emissions. The ratiometric approach allows sensing to be performed, regardless of issues surrounding collection efficiency (scattering environment, light fluctuations, etc.) and dye:NC loadings.
• US8101430B2
  申请人：——

  公开号：US8101430B2

  公开（公告）日：2012-01-24
• US8313957B2
  申请人：——

  公开号：US8313957B2

  公开（公告）日：2012-11-20
• Efficient detection of polycyclic aromatic hydrocarbons and polychlorinated biphenyls via three-component energy transfer
  作者：Nicole Serio、Kayla Miller、Mindy Levine

  DOI：10.1039/c3cc40534f

  日期：——

  Reported herein is the detection of highly toxic polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) via proximity-induced non-covalent energy transfer. This energy transfer occurs in the cavity of γ-cyclodextrin, and is efficient even with the most toxic PAHs and least fluorescent PCBs. The low limits of detection and potential for selective detection using array-based systems, combined with the straightforward experimental setup, make this new detection method particularly promising.

  本文报告的是通过近距离诱导的非共价能量转移检测剧毒多环芳烃（PAHs）和多氯联苯（PCBs）的方法。这种能量转移发生在 γ-环糊精的空腔中，即使对毒性最强的多环芳烃和荧光最少的多氯联苯也有效。利用基于阵列的系统进行选择性检测的低检测限和潜力，再加上简单的实验设置，使这种新的检测方法特别有前途。