N-amino-4-methoxy-N'-phenylbenzenecarboximidamide | 71114-60-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-amino-4-methoxy-N'-phenylbenzenecarboximidamide
• CAS: 71114-60-8
• 化学式: C₁₄H₁₅N₃O
• 分子量: 241.293
• InChiKey: XKKQAFRWKWFAFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  59.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  硫代异氰酸苯酯 、 N-amino-4-methoxy-N'-phenylbenzenecarboximidamide 以 氯仿 为溶剂， 以62%的产率得到2-((4-methoxyphenyl)(phenylamino)methylene)-N-phenylhydrazine-1-carbothioamide
  参考文献：
  名称：

  Synthesis and cytotoxic activity on islets of Langerhans of benzamide thiosemicarbazone derivatives

  摘要：

  Eleven 1-(4-substituted alpha-arylaminobenzylidene)thiosemicarbazides 1 and the related semicarbazones 2 were synthesized and tested in vitro for their inhibitory effects on the islets of Langerhans. Only the thiosemicarbazones 1 suppressed the insulin and glucagon secretions while the somatostatin release persisted. The 1-(alpha-anilino-4-methylbenzylidene)thiosemicarbazide 1f was the most potent suppressor of insulin release and lysed the islet beta cells. Zinc sulfate protected islets from the suppressive and toxic effects of 1f. These compounds 1 could be potential drugs for the treatment of insulinomas.

  DOI：

  10.1016/0223-5234(91)90059-v

文献信息

• 4,5-Bis(aryl)-4H-1,2,4-triazole derivatives and analgesic use
  申请人：Roussel Uclaf

  公开号：US04512997A1

  公开（公告）日：1985-04-23

  Novel 4H-1,2,4-triazoles of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be in different positions of the benzene rings and are individually selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, --CF.sub.3, --NO.sub.2, --NH.sub.2 and --NH--AlK and ##STR2## and AlK, AlK.sub.1 and AlK.sub.2 are alkyl of 1 to 4 carbon atoms or R.sub.1 and R.sub.2 together and/or R.sub.3 and R.sub.4 together are methylenedioxy, R is selected from the group consisting hydrogen, alkyl of 1 to 4 carbon atoms, --CH.sub.2 --COOH and --CH.sub.2 --COOAlK.sub.3 and AlK.sub.3 is alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having a remarkable analgesic activity and a novel method for their preparation.

  4H-1,2,4-三唑类新化合物的分子式为##STR1##其中R.sub.1、R.sub.2、R.sub.3和R.sub.4可以位于苯环的不同位置，分别选择自氢、--OH、1至4个碳原子的烷基、1至4个碳原子的烷氧基、卤素、--CF.sub.3、--NO.sub.2、--NH.sub.2和--NH--AlK和##STR2##以及AlK，AlK.sub.1和AlK.sub.2是1至4个碳原子的烷基，或者R.sub.1和R.sub.2一起和/或R.sub.3和R.sub.4一起是亚甲二氧基，R选择自氢、1至4个碳原子的烷基、--CH.sub.2 --COOH和--CH.sub.2 --COOAlK.sub.3，AlK.sub.3是1至4个碳原子的烷基，它们的无毒、药学上可接受的酸盐具有显著的镇痛活性，以及它们的制备新方法。
• DAVIDSON J., SYNTHESIS, 1979, NO 5, 359-361
  作者：DAVIDSON J.

  DOI：——

  日期：——
• US4512997A
  申请人：——

  公开号：US4512997A

  公开（公告）日：1985-04-23
• US4659729A
  申请人：——

  公开号：US4659729A

  公开（公告）日：1987-04-21
• US4727084A
  申请人：——

  公开号：US4727084A

  公开（公告）日：1988-02-23