N,N,N-trimethyl-L-alanyl-L-proline | 2177265-93-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N,N-trimethyl-L-alanyl-L-proline
• 英文别名: N,N,N-trimethyl-L-alanyl-L-proline betaine；TMAP；N, N, N-trimethyl-L-alanyl-proline-betaine；N,N,N-Trimethyl-L-alanyl-L-proline betaine；(2S)-1-[(2S)-2-(trimethylazaniumyl)propanoyl]pyrrolidine-2-carboxylate
• CAS: 2177265-93-7
• 化学式: C₁₁H₂₀N₂O₃
• 分子量: 228.291
• InChiKey: KXONJPJIFNGMCN-IUCAKERBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  trimethyl-[(2S)-1-[(2S)-2-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]azanium 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 N,N,N-trimethyl-L-alanyl-L-proline
  参考文献：
  名称：

  [EN] DIAGNOSTIC METHODS, THERAPEUTIC AGENTS AND USES THEREOF
  [FR] PROCÉDÉS DE DIAGNOSTIC, AGENT THÉRAPEUTIQUES ET LEURS UTILISATIONS

  摘要：

  本发明提供了化合物(I)或其盐，并将其用作生物标志物来评估或监测受试者的肾功能，确定发展肾功能减退的易感性，根据肾功能水平对受试者进行分类，诊断或监测慢性肾病。还描述了化合物(I)的组成和制备方法。

  公开号：

  WO2018022866A1

文献信息

• Compounds, reagents, and uses thereof
  申请人：Metabolon, Inc.

  公开号：US10865183B2

  公开（公告）日：2020-12-15

  The present invention provides a compound of formula (I) or a salt thereof and their use as a biomarker in assessing or monitoring kidney function in a subject, determining predisposition to developing reduced kidney function, classifying a subject according to level of kidney function, diagnosing or monitoring chronic kidney disease. Compositions and method of making of the compound of formula (I) are also described.

  本发明提供了一种式（I）化合物或其盐及其作为生物标记物在评估或监测受试者肾功能、确定肾功能减退的易感性、根据肾功能水平对受试者进行分类、诊断或监测慢性肾病中的用途。还描述了式 (I) 化合物的组成和制造方法。
• COMPOUNDS, REAGENTS, AND USES THEREOF
  申请人：Metabolon, Inc.

  公开号：US20190152907A1

  公开（公告）日：2019-05-23

  The present invention provides a compound of formula (I) or a salt thereof and their use as a biomarker in assessing or monitoring kidney function in a subject, determining predisposition to developing reduced kidney function, classifying a subject according to level of kidney function, diagnosing or monitoring chronic kidney disease. Compositions and method of making of the compound of formula (I) are also described.
• [EN] DIAGNOSTIC METHODS, THERAPEUTIC AGENTS AND USES THEREOF<br/>[FR] PROCÉDÉS DE DIAGNOSTIC, AGENT THÉRAPEUTIQUES ET LEURS UTILISATIONS
  申请人：METABOLON INC

  公开号：WO2018022866A1

  公开（公告）日：2018-02-01

  The present invention provides a compound of formula (I) or a salt thereof and their use as a biomarker in assessing or monitoring kidney function in a subject, determining predisposition to developing reduced kidney function, classifying a subject according to level of kidney function, diagnosing or monitoring chronic kidney disease. Compositions and method of making of the compound of formula (I) are also described.

  本发明提供了化合物(I)或其盐，并将其用作生物标志物来评估或监测受试者的肾功能，确定发展肾功能减退的易感性，根据肾功能水平对受试者进行分类，诊断或监测慢性肾病。还描述了化合物(I)的组成和制备方法。