1-n-butoxy-2,3-dimethoxypropane | 1242082-85-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1-n-butoxy-2,3-dimethoxypropane
• 英文别名: 1-(2,3-dimethoxypropoxy)butane；1-n-butoxy-2,3-dimetoxypropane；1-(2,3-Dimethoxypropoxy)butane
• CAS: 1242082-85-4
• 化学式: C₉H₂₀O₃
• 分子量: 176.256
• InChiKey: KQYOFUDJRNSWJH-UHFFFAOYSA-N

物化性质

• 沸点：
  199 °C
• 密度：
  0.896±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  正丁基缩水甘油醚 在 sodium hydride 、 potassium hydroxide 作用下， 以 四氢呋喃 为溶剂， 生成 1-n-butoxy-2,3-dimethoxypropane
  参考文献：
  名称：

  Ecotoxicity studies of glycerol ethers in Vibrio fischeri: checking the environmental impact of glycerol-derived solvents

  摘要：

  大多数由甘油衍生的醚类化合物对生物标志物弧菌菲氏弧菌的生态毒性低或无，这证明了这种基于生物的溶剂家族对环境的影响较小。

  DOI：

  10.1039/c5gc00857c

文献信息

• 1,2,3-Trimethoxypropane and Glycerol Ethers as Bio-Sourced Solvents from Glycerol. Synthesis by Solvent-Free Phase-Transfer Catalysis and Utilization as an Alternative Solvent in Chemical Transformations
  作者：Marc Sutter、Wissam Dayoub、Estelle Métay、Yann Raoul、Marc Lemaire

  DOI：10.1002/cctc.201300458

  日期：2013.10

  phase‐transfer catalyst with no additional solvent. No heating was required, and the synthesis was easily performed under atmospheric pressure on a 150 g scale. For the preparation of 2, the conversion of glycerol was complete and the selectivity for the expected glycerol trimethylether was above 95 %. This product was utilized as a solvent in organic reactions such as transesterifications between glycerol

  1,2,3-三甲氧基丙烷（2），1-烷氧基-2,3-二甲氧基丙烷和1-芳氧基-2,3-二甲氧基丙烷在固相转移催化中得到了良好的收率和选择性。无机碱和铵盐作为相转移催化剂，无需其他溶剂。不需要加热，并且容易在大气压下以150g规模进行合成。准备2，甘油的转化完成，并且预期的甘油三甲醚的选择性高于95％。该产品在有机反应中用作溶剂，例如甘油和植物油之间的酯交换反应，有机金属反应（格氏和巴比尔型反应），碳-碳偶联反应（Suzuki，Sonogashira，Heck）以及在脱氢反应中的醚化反应中烷基化。溶剂显示出有趣的聚合物增溶性能。
• ALKOXYSILANE COMPOUNDS HAVING FLUOROALKYL GROUP AND METHOD OF PREPARING THE SAME
  申请人：Honma Takayuki

  公开号：US20120264964A1

  公开（公告）日：2012-10-18

  Alkoxysilane compounds having two fluoroalkyl groups and represented by the formula (1): wherein R f and R f ′ are each a fluoroalkyl group of 1 to 10 carbon atoms, R 1 is a hydrogen atom or an aliphatic monovalent hydrocarbon group of 1 to 6 carbon atoms, R 2 and R 3 are each methyl group or ethyl group, X and Y are each an ether linkage or an ester linkage, a and b are each 0 or 1, m, n and p are each an integer of 0 to 6, q is an integer of 1 to 6, and r is an integer of 0 to 2. By treating an inorganic material with the alkoxysilane compound having ether linkage and two fluoroalkyl groups, high water and oil repellency and high sliding properties are imparted to the inorganic material. The alkoxysilane compounds are easily purified, owing to enhanced volatility by the branched structure.

  具有两个氟烷基团的烷氧基硅烷化合物，其化学式表示为（1）：其中Rf和Rf'均为1至10个碳原子的氟烷基团，R1为氢原子或1至6个碳原子的脂肪族一价碳氢基团，R2和R3均为甲基基团或乙基基团，X和Y均为醚键或酯键，a和b均为0或1，m、n和p均为0至6的整数，q为1至6的整数，r为0至2的整数。通过用具有醚键和两个氟烷基团的烷氧基硅烷化合物处理无机材料，可以赋予无机材料高水和油抗性以及高滑动性能。由于分支结构提高了挥发性，这些烷氧基硅烷化合物易于纯化。
• BISPHENOL COMPOUNDS AND METHODS FOR THEIR USE
  申请人：Andersen Raymond John

  公开号：US20140248263A1

  公开（公告）日：2014-09-04

  Compounds having a structure of Formula I: wherein G, a, Q, L 2 , R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein are provided. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.

  提供具有公式I结构的化合物，其中G，a，Q，L2，R1，R2，R3，R4，R5和R6的定义如本文所述。提供了这种化合物用于治疗各种适应症，包括前列腺癌以及涉及这种化合物的治疗方法。
• Silicon-containing resist underlayer film-forming composition and patterning process
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP2599819B1

  公开（公告）日：2017-02-01
• STABLE PHARMACEUTICAL COMPOSITIONS OF PEPTIDE DERIVATIZED USING AN OXIME LINKER
  申请人：Reslow Mats

  公开号：US20120108512A1

  公开（公告）日：2012-05-03

  The invention relates to stable pharmaceutical compositions comprising a therapeutic peptide derivatized with a property-modifying group, wherein the property-modifying group is conjugated to the peptide by use of a linker comprising an oxime bond.