4-phenyl-5-[4-chlorophenylthio]-pent-1-ene | 1220552-18-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-phenyl-5-[4-chlorophenylthio]-pent-1-ene
• 英文别名: 1-Chloro-4-(2-phenylpent-4-enylsulfanyl)benzene
• CAS: 1220552-18-0
• 化学式: C₁₇H₁₇ClS
• 分子量: 288.841
• InChiKey: JKDNQTZHDCFZLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯乙烯 、 4-chloro-benzenesulfenyl chloride 、 烯丙基三甲基硅烷 以 二氯甲烷 、 hexafluoropropan-2-ol 为溶剂， 反应 0.08h， 以93%的产率得到4-phenyl-5-[4-chlorophenylthio]-pent-1-ene
  参考文献：
  名称：

  Elaboration of a Lewis acid-free protocol for the alkylation of silicon-containing π-donors by β-arylthioalkyl chlorides

  摘要：

  Hexafluoroisopropanol (HFIP) was found to be a powerful electrophilic activator of covalent reagents. Due to this effect the title reaction was shown to proceed under mild conditions in the absence of any Lewis acid catalysts to give the respective products of C-alkylation in good to excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.01.045

文献信息

• Elaboration of a Lewis acid-free protocol for the alkylation of silicon-containing π-donors by β-arylthioalkyl chlorides
  作者：Maxim O. Ratnikov、Vasily V. Tumanov、William A. Smit

  DOI：10.1016/j.tet.2010.01.045

  日期：2010.3

  Hexafluoroisopropanol (HFIP) was found to be a powerful electrophilic activator of covalent reagents. Due to this effect the title reaction was shown to proceed under mild conditions in the absence of any Lewis acid catalysts to give the respective products of C-alkylation in good to excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.