1-Methylheptanesulfonamide | 10435-96-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 1-Methylheptanesulfonamide
• 英文别名: 2-Octylsulfonamid；2-octanesulfonamide；Octane-2-sulfonamide
• CAS: 10435-96-8
• 化学式: C₈H₁₉NO₂S
• 分子量: 193.31
• InChiKey: LSFBLIOSFQFPBQ-UHFFFAOYSA-N

物化性质

• 沸点：
  297.2±23.0 °C(Predicted)
• 密度：
  1.041±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-carboxy-3-(2,4-dichlorobenzyl)-2-methylindole 、 1-Methylheptanesulfonamide 在 di-aza-bicycloundecene 、 N,N'-羰基二咪唑 作用下， 生成 3-(2,4-dichlorobenzyl)-2-methyl-5-(2-octanesulfonylcarbamoyl)-indole
  参考文献：
  名称：

  Method for inhibiting neoplastic cells with indole derivatives

  摘要：

  通过将其暴露于取代吲哚衍生物中来抑制肿瘤细胞及相关病症的方法。

  公开号：

  US06410584B1
• 作为产物：
  描述：

  在 盐酸 作用下， 以 乙醇 为溶剂， 以95%的产率得到1-Methylheptanesulfonamide
  参考文献：
  名称：

  A new synthesis of α-functionalized unsubstituted sulfonamides

  摘要：

  DOI：

  10.1016/s0040-4039(00)88845-0

文献信息

• Method of inhibiting neoplastic cells with indole derivatives
  申请人：——

  公开号：US20020143022A1

  公开（公告）日：2002-10-03

  A method for inhibiting neoplastic cells and related conditions by exposing them to substituted indole derivatives.

  通过将替代吲哚衍生物暴露给肿瘤细胞及其相关情况，抑制其生长的方法。
• Asymmetric synthesis of .alpha.-functionalized primary sulfonamides
  作者：Franklin A. Davis、Ping Zhou、Patrick J. Carroll

  DOI：10.1021/jo00070a026

  日期：1993.8

  Alpha-Functionalized primary sulfonamides 8 are prepared in good to excellent yields by treatment of the dianions of N-sulfonylcamphorimines 1-3 with electrophiles and hydrolysis of the resulting imines 5-7. Alkylation of the anions of N-sulfonyl-10-camphorsulfonamide imines 2 and 3 with primary and secondary alkyl iodides and with ethylene oxide, following removal of the chiral auxiliary with aqueous acid, gave primary sulfonamides with ee's in the range of 66-95%.
• Electrophilic Substitution at Saturated Carbon. XXV. Structural Requirements for Functional Groups Centered around Second-Row Elements to Preserve Asymmetry of Carbanions^1,2
  作者：Donald J. Cram、Robert D. Trepka、P. St. Janiak

  DOI：10.1021/ja00964a025

  日期：1966.6
• ACIDIFIED CHLORITE COMPOSITIONS CONTAINING NITROGENOUS STABILIZERS AND SYSTEMS AND METHODS RELATED THERETO
  申请人：ALCIDE CORPORATION

  公开号：EP1558078A2

  公开（公告）日：2005-08-03
• Acidified chlorite compositions containing nitrogenous stabilizers and systems and methods related thereto
  申请人：Alcide Corporation

  公开号：US20040166136A1

  公开（公告）日：2004-08-26

  A two-part disinfecting system, as well as disinfecting compositions and methods for making and using the same. The two-part disinfecting system contains a first part and a second part adapted to be mixed to yield an aqueous acidic disinfecting composition, wherein the first part comprises a chlorite and the second part comprises an acid, and wherein the first part, the second part, or both the first and second parts further comprise a nitrogenous stabilizer having a nitrogen group substituted with at least one hydrogen.