tert-butyl N-[2-(cyanomethyl)phenyl]carbamate | 1238507-98-6

• 物质功能分类: 化学试剂 - 有机试剂 - 酯类
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-[2-(cyanomethyl)phenyl]carbamate
• CAS: 1238507-98-6
• 化学式: C₁₃H₁₆N₂O₂
• 分子量: 232.282
• InChiKey: ICYVGAIGAONACQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  62.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二碳酸二叔丁酯 、 2-氨基苯乙腈 在 12-TPA/SBA 15 作用下， 反应 0.17h， 以95%的产率得到tert-butyl N-[2-(cyanomethyl)phenyl]carbamate
  参考文献：
  名称：

  An expeditious, efficient green methodology for the Boc protection of amines and silyl protection of alcohols over tungstophosphoric acid-doped mesoporous silica

  摘要：

  An efficient, chemoselective and eco-friendly protocol for the protection of amines as N-tert-butylcarbamate using (Boc)(2)O and protection of alcohols as silyl ether using HMDS over tungstophosphoric acid/SBA15 has been developed. Solventless condition, easy work-up, short reaction time, excellent yields and reusability of the catalyst are the striking features of this methodology which can be considered to be one of the better methods for the protection of amines and alcohols. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.05.080

文献信息

• An expeditious, efficient green methodology for the Boc protection of amines and silyl protection of alcohols over tungstophosphoric acid-doped mesoporous silica
  作者：Bikash Karmakar、Julie Banerji

  DOI：10.1016/j.tetlet.2010.05.080

  日期：2010.7

  An efficient, chemoselective and eco-friendly protocol for the protection of amines as N-tert-butylcarbamate using (Boc)(2)O and protection of alcohols as silyl ether using HMDS over tungstophosphoric acid/SBA15 has been developed. Solventless condition, easy work-up, short reaction time, excellent yields and reusability of the catalyst are the striking features of this methodology which can be considered to be one of the better methods for the protection of amines and alcohols. (C) 2010 Elsevier Ltd. All rights reserved.