Benzenemethanamine, 4-(2-methyl-1,3-dioxolan-2-yl)- | 66522-61-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzenemethanamine, 4-(2-methyl-1,3-dioxolan-2-yl)-
• 英文别名: [4-(2-methyl-1,3-dioxolan-2-yl)phenyl]methanamine
• CAS: 66522-61-0
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.24
• InChiKey: FNYJTLDRTBOOGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Benzenemethanamine, 4-(2-methyl-1,3-dioxolan-2-yl)- 生成 1,3-Bis-(4-acetyl-benzyl)-urea
  参考文献：
  名称：

  KORYTNYK W.; ANGELINO N.; DAVE C.; CABALLES L., J. MED. CHEM., 1978, 21, NO 6, 507-513

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(2-methyl-1,3-dioxolan-2-yl)benzonitrile 、 氢化铝锂 生成 Benzenemethanamine, 4-(2-methyl-1,3-dioxolan-2-yl)-
  参考文献：
  名称：

  KORYTNYK W.; ANGELINO N.; DAVE C.; CABALLES L., J. MED. CHEM., 1978, 21, NO 6, 507-513

  摘要：

  DOI：

文献信息

• Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of pde4 isozymes
  申请人：——

  公开号：US20030186989A1

  公开（公告）日：2003-10-02

  Compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructive pulmonary disease, of Formula (1.0.0): 1 wherein R 5 and R 6 are taken together to form a moiety of partial Formulas (1.1.1) through (1.1.5): 2 or a pharmaceutically acceptable salt thereof.

  在治疗由嗜酸性粒细胞的激活和脱颗粒调节的疾病，特别是哮喘、慢性支气管炎和慢性阻塞性肺病中作为PDE4抑制剂有用的化合物，其化学式为（1.0.0）： 其中R5和R6一起取代形成部分化学式（1.1.1）至（1.1.5）的基团， 或其药用可接受的盐。
• [EN] N-ALKYL PYRROLES AS HMG-COA REDUCTASE INHIBITORS<br/>[FR] PYRROLES DE N-ALKYL COMME INHIBITEURS DE L'HMG-COA-REDUCTASE
  申请人：WARNER LAMBERT CO

  公开号：WO2005056004A1

  公开（公告）日：2005-06-23

  HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided. Formula (I).

  提供了作为降胆固醇和降脂化合物有用的HMGCo-A还原酶抑制剂化合物。还提供了这些化合物的药物组合物。还提供了制备这些化合物的方法和使用这些化合物的方法。公式（I）。
• [EN] 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS<br/>[FR] 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES SUBSTITUES EN POSITION 6 EN TANT QU'AGONISTES DE RECEPTEUR 5-HT2C
  申请人：LILLY CO ELI

  公开号：WO2005082859A1

  公开（公告）日：2005-09-09

  The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: I where: R6 is -C=C-R10, -O-R12, -S-R14, or -NR24R25; and other substituents are as defined in the specification.

  本发明提供了公式I中的6-取代的2,3,4,5-四氢-1H-苯并[d]氮杂环庚烯作为选择性5-HT2C受体激动剂，用于治疗与5-HT2C相关的疾病，包括肥胖症、强迫症/强迫性障碍、抑郁症和焦虑症：I其中：R6为-C=C-R10，-O-R12，-S-R14或-NR24R25；其他取代基如规范中所定义。
• Amide compound and method of controlling plant disease with the same
  申请人：Sakaguchi Hiroshi

  公开号：US20060122065A1

  公开（公告）日：2006-06-08

  A amid compound of the formula (1): wherein, in the formula, R 51 represents a halogen atom, a C1-C6 alkyl group and the like; R 52 represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group and the like; R 53 represents a halogen atom and the like; R 56 represents a halogen atom and the like; R 57 represents a hydrogen atom and the like; R 58 and R 59 independently represent a hydrogen atom, a C1-C3 alkyl group and the like; R 60 represents a C1-C4 alkyl group, a C1-C4 haloalkyl group, a C3-C4 alkenyl group, or a C3-C6 alkynyl group; R 61 represents a C1-C4 alkyl group, a C1-C4 haloalkyl group, a C3-C4 alkenyl group or a C3-C6 alkynyl group or a C2-C4 cyanoalkyl group; R 62 , R 63 and R 64 represent a hydrogen atom, a halogen atom and the like; X represents a oxygen atom or a sulfur atom; has an excellent activity against plant diseases.

  一种化合物的公式（1）：其中，在公式中，R51代表卤素原子，C1-C6烷基等；R52代表氢原子，卤素原子，C1-C6烷基等；R53代表卤素原子等；R56代表卤素原子等；R57代表氢原子等；R58和R59分别独立地代表氢原子，C1-C3烷基等；R60代表C1-C4烷基，C1-C4卤代烷基，C3-C4烯基或C3-C6炔基；R61代表C1-C4烷基，C1-C4卤代烷基，C3-C4烯基或C3-C6炔基或C2-C4氰基烷基；R62，R63和R64代表氢原子，卤素原子等；X代表氧原子或硫原子；具有出色的植物病害活性。
• Cephem compounds having a terminal aminocarboxylic acid grouping and
  申请人：Ciba Geigy Corporation

  公开号：US04464366A1

  公开（公告）日：1984-08-07

  Compounds of the formula ##STR1## in which the index n represents an integer of from 1 to 4, the index m represents 0 or 1, X represents oxygen, sulphur or the group --NH--, W represents a group --CO--, --CO--NHSO.sub.2 -- or --SO.sub.2 NH--CO--, or X-W together represent a group --CO-- or --CO--NHSO.sub.2 --, A represents optionally substituted phenylene, thienylene or furylene, Z represents oxygen or sulphur, Y represents lower alkylene, the index k represents the value 1 or 2, R.sub.4 represents hydrogen, an optionally substituted lower aliphatic or cycloaliphatic radical or acyl, R.sub.1 represents hydrogen, lower alkyl, lower alkoxy, halogen or a group of the formula --CH.sub.2 --R.sub.2 in which R.sub.2 represents a free, esterified or etherified hydroxy or mercapto group or a quaternary ammonium group, and R.sub.3 represents hydrogen or methoxy, and in which the carboxyl groups are optionally esterified in a form that can be split under physiological conditions, and salts of such compounds having salt-forming groups, are obtained by liberating the functional group(s) in a compound of the formula I in which at least one of the functional groups present is protected. The compounds are effective in vitro and in vivo against gram-positive and gram-negative bacteria and cocci.

  式为##STR1##的化合物，其中指数n表示1到4的整数，指数m表示0或1，X表示氧、硫或基团--NH--，W表示基团--CO--、--CO--NHSO.sub.2 --或--SO.sub.2 NH--CO--，或X-W一起表示基团--CO--或--CO--NHSO.sub.2 --，A表示可选择取代的苯、噻吩或呋喃基，Z表示氧或硫，Y表示低碳烷基，指数k表示值为1或2，R.sub.4表示氢、可选择取代的低脂肪或环脂肪基或酰基，R.sub.1表示氢、低烷基、低烷氧基、卤素或式--CH.sub.2 --R.sub.2的基团，其中R.sub.2表示自由、酯化或醚化的羟基或巯基或季铵基，R.sub.3表示氢或甲氧基，其中羧基在可分裂的生理条件下可选择酯化，以及具有盐基团的这种化合物的盐，是通过在式I的化合物中释放至少一种保护的官能团获得的。这些化合物在体内外对革兰氏阳性和革兰氏阴性细菌和球菌具有有效性。