3-Benzoylamino-5,6,7,8-tetrahydroquinoline-4(1H)one | 151225-14-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Benzoylamino-5,6,7,8-tetrahydroquinoline-4(1H)one
• 英文别名: N-(4-oxo-5,6,7,8-tetrahydro-1H-quinolin-3-yl)benzamide
• CAS: 151225-14-8
• 化学式: C₁₆H₁₆N₂O₂
• 分子量: 268.315
• InChiKey: XZWMTTHOJMWSQN-UHFFFAOYSA-N

物化性质

• 沸点：
  513.4±50.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-Benzoylamino-5,6,7,8-tetrahydroquinoline-4(1H)one 在 三氯氧磷 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 15.0h， 以77%的产率得到N'-(4-chloro-5,6,7,8-tetrahydroquinolin-3-yl)-N,N-dimethylmethanimidamide
  参考文献：
  名称：

  Intermolecular transfer of an alkenyl group in enamines: Application to synthesis of [b]-fused pyridines

  摘要：

  A novel intermolecular alkenyl transfer of enamines was developed for the preparation of cycloalkenylaminomethyleneoxazolones, which were thermally cyclized to [b]-fused pyridines in good yields. The functional manipulation of the pyridines provided versatile precursors for further annulation to tricyclic ring systems. Copyright (C) 1996 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(96)02071-0
• 作为产物：
  描述：

  4-Aminomethylen-2-phenyl-oxazolon-(5) 以 乙酸酐 为溶剂， 反应 2.0h， 生成 3-Benzoylamino-5,6,7,8-tetrahydroquinoline-4(1H)one
  参考文献：
  名称：

  Intermolecular transfer of an alkenyl group in enamines: Application to synthesis of [b]-fused pyridines

  摘要：

  A novel intermolecular alkenyl transfer of enamines was developed for the preparation of cycloalkenylaminomethyleneoxazolones, which were thermally cyclized to [b]-fused pyridines in good yields. The functional manipulation of the pyridines provided versatile precursors for further annulation to tricyclic ring systems. Copyright (C) 1996 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(96)02071-0

文献信息

• Condensed imidazopyridine derivatives
  申请人：Shionogi & Co., Ltd.

  公开号：US05378848A1

  公开（公告）日：1995-01-03

  A compound of the formula: ##STR1## wherein R is an optionally substituted aryl group or an optionally substituted aromatic heterocycle group; A ring is a 5 to 9 membered alicyclic group, in which one or more of carbon atoms constituting said A ring may be replaced by O, or S and said A ring may have alkyl as a substituent, or a pharmaceutically acceptable salt thereof.

  式I化合物：##STR1## 其中R为任选取代的芳基或任选取代的芳香杂环基团；A环为5至9元脂环族基团，其中构成A环的一个或多个碳原子可被O或S替换，且A环可具有烷基作为取代基，或其药学上可接受的盐。
• Intermolecular transfer of an alkenyl group in enamines: Application to synthesis of [b]-fused pyridines
  作者：Makoto Adachi、Takashi Sasatani、Nobuo Chomei、Susumu Takada

  DOI：10.1016/s0040-4039(96)02071-0

  日期：1996.12

  A novel intermolecular alkenyl transfer of enamines was developed for the preparation of cycloalkenylaminomethyleneoxazolones, which were thermally cyclized to [b]-fused pyridines in good yields. The functional manipulation of the pyridines provided versatile precursors for further annulation to tricyclic ring systems. Copyright (C) 1996 Elsevier Science Ltd.