1-hydroxy-6-methyl-2-pyridone | 50405-67-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-hydroxy-6-methyl-2-pyridone
• 英文别名: 1-Hydroxy-6-methylpyridin-2(1H)-one；1-hydroxy-6-methylpyridin-2-one
• CAS: 50405-67-9
• 化学式: C₆H₇NO₂
• 分子量: 125.127
• InChiKey: IEFRQNQEFHXQTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-hydroxy-6-methyl-2-pyridone 在 甲醇 、 乙醚 、 乙醇 、 potassium ethoxide 、 sodium methylate 作用下， 生成 (1-methoxy-6-oxo-1,6-dihydro-[2]pyridyl)-pyruvic acid ethyl ester
  参考文献：
  名称：

  A Synthesis of 6-Hydroxy-4-quinolizones

  摘要：

  DOI：

  10.1021/ja01519a059
• 作为产物：
  描述：

  2-溴-6-甲基吡啶 在 盐酸 、 水 、 溶剂黄146 、 苯甲醇 作用下， 生成 1-hydroxy-6-methyl-2-pyridone
  参考文献：
  名称：

  Condensation Reactions of Picoline 1-Oxides

  摘要：

  DOI：

  10.1021/ja01641a017

文献信息

• REINFORCED MACROCYCLIC LIGANDS, COMPLEXES THEREOF, AND USES OF SAME
  申请人：GUERBET

  公开号：US20200157101A1

  公开（公告）日：2020-05-21

  Ligands that are based on the pyclen macrocycle that are reinforced, which are useful for complexing elements such as radioelements and/or elements with magnetic properties.

  基于pyclen大环的配体被加固，对于络合放射性元素和/或具有磁性属性的元素是有用的。
• MACROCYCLES
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20150157746A1

  公开（公告）日：2015-06-11

  The invention provides macrocycles useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.

  这项发明提供了在螯合金属离子中特别是放射性核素中有用的大环化合物，以提供金属离子配合物。该发明还提供了使用这些化合物和配合物的方法，例如在治疗和诊断应用中。
• METALLOPROTEIN INHIBITORS
  申请人：Puerta T. David

  公开号：US20070117848A1

  公开（公告）日：2007-05-24

  The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R 1 , R 2 , R 3 , and R 4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.

  本发明涉及金属蛋白酶抑制剂，包括：a. 有机取代基和至少一个锌结合基团（ZBG）共价连接在一起；或者b. 通过侧链取代的ZBG，其中ZBG的公式为（I）：其中X为O或S，每个R1、R2、R3和R4分别为氢或有机基团。这些金属蛋白酶抑制剂可用于预防或治疗与病理性金属蛋白酶活性相关的病理性疾病、状况或症状，或者通过抑制该活性缓解的病理性疾病、状况或症状。
• Pharmaceutical compositions containing 1-hydroxypyrid-2-one derivatives
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0138420A2

  公开（公告）日：1985-04-24

  Compounds which are a 1-hydroxypyrid-2-one in which one or more of the hydrogen atoms attached to ring carbon atoms are eplaced by a substituent selected from aliphatic acyl, aliphatic amide, aliphatic amine, carboxy, cyano, aliphatic ester, halogen, hydroxy and sulpho groups, alkoxy groups and alkoxy groups substituted by an alkoxy, aliphatic amide, aliphatic amine, alipha- :ic ester, halogen or hydroxy group, aliphatic hydrocarbon groups and aliphatic hydrocarbon groups substitued by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected onyl by substituents selected from aliphatic hydrocarbon groups, halogen groups and aliphatic hydrocarbon groups substituted by a halogen group, or a salt thereof contain- ng a physiolgically acceptable ion or ions, are of value in the :reatment of patients having a toxic concentration of a metal, particularly iron, in the body whilst the iron complexes of such compounds are of value in the treatment of iron deficiency anaemia.

  1- 羟基吡啶-2-酮的化合物，其中连接到环碳原子上的一个或多个氢原子被选自脂族酰基、脂族酰胺、脂族胺、羧基、氰基、脂族酯、卤素、羟基和磺基、烷氧基和被烷氧基取代的烷氧基、脂族酰胺、脂族胺、脂族酯、卤素或羟基、脂族烃基和被烷氧基、脂族酯、卤素或羟基取代的脂族烃基的取代基取代的化合物：烷氧基基团和被烷氧基、脂肪族酯、卤素或羟基取代的烷氧基基团和脂肪族烷氧基基团，但不包括通过选自脂 肪族烃基团、卤素基团和被卤素基团取代的脂肪族烃基团的取代基取代化合物中氢原子的化合物，或含有一种 或多种生理上可接受的离子的盐，在......治疗具有毒性的患者方面具有价值：此类化合物的铁络合物在治疗缺铁性贫血症方面具有价值。
• SHEET FOR CLEANING
  申请人：Kao Corporation

  公开号：EP0997142A1

  公开（公告）日：2000-05-03

  The invention relates to a cleansing sheet obtained by impregnating a nonwoven fabric composed of a continuous long fiber with oil-absorbing powder and a lower alcohol. The sheet has high detergency to not only a stain or smear on the skin, but also sebum, can keep the skin clean, can be used irrespective of place and has good stability.

  本发明涉及一种通过在由连续长纤维组成的无纺布上浸渍吸油粉末和低级酒精而获得的清洁片材。该洁肤片不仅对皮肤上的污渍或涂抹物，而且对皮脂都有很高的去污力，能保持皮肤清洁，可在任何地方使用，并具有良好的稳定性。