Methyl 3-amino-2-(methylamino)propanoate | 751454-97-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 3-amino-2-(methylamino)propanoate
• CAS: 751454-97-4
• 化学式: C₅H₁₂N₂O₂
• 分子量: 132.162
• InChiKey: OUFGQJKQGLSTHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N'-[Imino(methylsulfanyl)methyl]-N,N-dimethylcarbamimidic acid 、 Methyl 3-amino-2-(methylamino)propanoate 在 sodium acetate 作用下， 生成
  参考文献：
  名称：

  SAR studies on dihydropyrimidinone antibiotics

  摘要：

  There is an urgent need for the development of novel antimicrobial agents that offer effective treatment against MRSA. Using a new class of dipeptide antibiotic TAN-1057A/B as lead, we designed, synthesized and evaluated analogs of TAN-1057A/B. Several novel dihydropyrimidinone antibiotics demonstrating comparable antibiotic efficacy while possessing favorable selectivity were identified. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.01.099

文献信息

• SAR studies on dihydropyrimidinone antibiotics
  作者：Lianhong Xu、Lijun Zhang、Robert Jones、Clifford Bryant、Nina Boddeker、Eric Mabery、Gina Bahador、Julia Watson、Jeffery Clough、Murty Arimilli、Wendy Gillette、Dorothy Colagiovanni、Keyu Wang、Craig Gibbs、Choung U. Kim

  DOI：10.1016/j.bmcl.2011.01.099

  日期：2011.3

  There is an urgent need for the development of novel antimicrobial agents that offer effective treatment against MRSA. Using a new class of dipeptide antibiotic TAN-1057A/B as lead, we designed, synthesized and evaluated analogs of TAN-1057A/B. Several novel dihydropyrimidinone antibiotics demonstrating comparable antibiotic efficacy while possessing favorable selectivity were identified. (C) 2011 Elsevier Ltd. All rights reserved.