1-(2,4-dichlorophenyl)-2,2-dimethylpropane-1,3-diol | 155927-18-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2,4-dichlorophenyl)-2,2-dimethylpropane-1,3-diol
• CAS: 155927-18-7
• 化学式: C₁₁H₁₄Cl₂O₂
• 分子量: 249.137
• InChiKey: LWEOSRBDQCZAPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2,4-dichlorophenyl)-2,2-dimethylpropane-1,3-diol 在 sodium hydroxide 、 三乙胺 、 三氯氧磷 作用下， 以 二氯甲烷 为溶剂， 反应 3.25h， 生成 (-)-4-(2,4-dichlorophenyl)-5,5-dimethyl-2-hydroxy-1,3,2-dioxaphosphorinane 2-oxide
  参考文献：
  名称：

  The design of resolving agents. Chiral cyclic phosphoric acids

  摘要：

  DOI：

  10.1021/jo00223a018
• 作为产物：
  描述：

  2,4-二氯苯甲醛 、 异丁醛 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 生成 1-(2,4-dichlorophenyl)-2,2-dimethylpropane-1,3-diol
  参考文献：
  名称：

  用于通过阳极氧化对仲胺进行 α-烷基化的磷衍生手性助剂

  摘要：

  研究了手性磷​​基结构作为阳极氧化的 N 活化基团和手性电感器。第一项研究展示了吡咯烷的结果，其中烯丙基三甲基硅烷作为标准亲核试剂。以优异的产率 (82-98%) 获得了甲氧基化的化合物。关于手性助剂，讨论了烷基化步骤的非对映选择性 (18-66%)。

  DOI：

  10.1055/s-2006-950226

文献信息

• Phosphorus-Derived Chiral Auxiliaries for α-Alkylation of Secondary Amines by Anodic Oxidation
  作者：Thierry Martens、Emma Sierecki、Serge Turcaud、Jacques Royer

  DOI：10.1055/s-2006-950226

  日期：——

  Chiral phosphorus-based structures were investigated as N-activating groups for anodic oxidation and as chiral inductors. This first study presents the results obtained for pyrrolidine, with allyltrimethylsilane as a standard nucleophile. The methoxylated compounds were obtained in excellent yields (82-98%). The diastereoselectivity of the alkylation step (18-66%) is discussed with regard to the chiral

  研究了手性磷​​基结构作为阳极氧化的 N 活化基团和手性电感器。第一项研究展示了吡咯烷的结果，其中烯丙基三甲基硅烷作为标准亲核试剂。以优异的产率 (82-98%) 获得了甲氧基化的化合物。关于手性助剂，讨论了烷基化步骤的非对映选择性 (18-66%)。
• Synthesis and Fugicidal Activities of 2-Silatranyl Propylamino-4-substitued Phenyl(Hydrogen)-5,5-dimethyl-1,3,2-dioxaphosphinanes-2-oxides (Sulfides)
  作者：Shi-Guan Wan、Xing-Yu Yang、Yan Yu、Chang Liu

  DOI：10.1080/104265090968343

  日期：2005.12

  Phosphoryl-aminopropyl-silatranes 4 were synthesized by nucleophilic reactions of 2-Cl-1,3,2- dioxaphosphinanes 2 with gamma-aminopropyl-silatrane 3, which was obtained by the cyclization reaction of triethanolamine and gamma-aminopropyltriethoxysilane. The structures of the products were characterized by H-1 NMR, P-31 NMR, IR, MS, and elemental analyses. The target compounds 4 exhibited fungicidal activity.
• The Synthesis and Biological Activities of <i>N</i>-(3-pyridylmethyl) <i>N</i> ′-(trans-2-thio-4-substitutedphenyl- 5,5-dimethyl-1,3,2-dioxaphosphinane-2-yl)thioureas
  作者：De-Qing Shi、Abudhaim Feras、Y. Hamdan、Yi Liu、Xiao-Song Tan

  DOI：10.1080/10426500500542968

  日期：2006.8.1

  A series of novel title compounds were synthesized by the addition reaction of trans 2-isothiocyano-4-substitutedphenyl-5,5-dimethyl-1,3,2-dioxaphosphinane-2-sulfide to 3-aminomethylpyridine or 2-chloro-5-amino methylpyridine. Their structures were confirmed by H-1 NMR, P-31 NMR, IR, MS, and elemental analyses. Results of preliminary bioassay showed that all new compounds possess good fungicidal activity and insecticidal activity to some extent.
• HOEVE, W. TEN;WYNBERG, H., J. ORG. CHEM., 1985, 50, N 23, 4508-4514
  作者：HOEVE, W. TEN、WYNBERG, H.

  DOI：——

  日期：——
• The design of resolving agents. Chiral cyclic phosphoric acids
  作者：Wolter Ten Hoeve、Hans Wynberg

  DOI：10.1021/jo00223a018

  日期：1985.11