9,10-Dihydroxy-12-octadecensaeure | 53734-70-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 9,10-Dihydroxy-12-octadecensaeure
• 英文别名: 9,10-Dihydroxy-12-octadecenoic acid；(E)-9,10-dihydroxyoctadec-12-enoic acid
• CAS: 53734-70-6；59959-42-1；59959-43-2；59959-49-8；59959-50-1；125356-85-6；125356-86-7；125356-87-8；125356-88-9
• 化学式: C₁₈H₃₄O₄
• 分子量: 314.466
• InChiKey: XEBKSQSGNGRGDW-JXMROGBWSA-N

物化性质

• 沸点：
  491.8±35.0 °C(Predicted)
• 密度：
  1.015±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Compositions of matter that reduce pain, shock, and inflammation by blocking linoleic acid metabolites and uses thereof
  申请人：Board of Regents of the University of Texas System

  公开号：US10100317B2

  公开（公告）日：2018-10-16

  A method for treating and/or diagnosing pain and the source or type of pain, shock, and/or inflammatory conditions in a subject. A method of using a therapeutically effective amount of a DNA or RNA aptamer that shows high affinity for OLAMs to at least partially treat pain, shock, and/or inflammatory conditions in a subject. The DNA or RNA aptamer that shows high affinity for OLAMs may be coupled to a plasma protein binding compound or a pharmacologically active agent. A method of treating and or diagnosing pain, shock, and/or inflammatory conditions in a subject may include inactivating or preventing at least one linoleic acid metabolite to treat certain conditions (e.g., pain, shock, and/or inflammation) using a DNA or RNA aptamer that shows high affinity for OLAMs.

  一种治疗和/或诊断受试者疼痛以及疼痛、休克和/或炎症的来源或类型的方法。一种使用对 OLAMs 具有高亲和力的治疗有效量的 DNA 或 RNA 合体来至少部分治疗受试者的疼痛、休克和/或炎症的方法。对 OLAMs 具有高亲和力的 DNA 或 RNA 合体可与血浆蛋白结合化合物或药理活性剂偶联。治疗和或诊断受试者疼痛、休克和/或炎症的方法可包括使用对 OLAMs 表现出高亲和力的 DNA 或 RNA 合酶灭活或阻止至少一种亚油酸代谢物，以治疗某些病症（如疼痛、休克和/或炎症）。
• Dihydroxy unsaturated fatty acid levels as diagnostic markers
  申请人：——

  公开号：US20030113824A1

  公开（公告）日：2003-06-19

  The invention provides methods of using dihydroxy unsaturated fatty acids as markers for identifying patients with a disorder associated with abnormal regulation of the cytochrome P450 metabolism or oxidation of unsaturated fatty acids. In preferred embodiments, linoleic acid diols, including, but not limited to, leukotoxindiol, are used as a diagnostic tool for identifying patients with pre-eclampsia, eclampsia, and pregnancy-induced hypertension.

  本发明提供了使用二羟基不饱和脂肪酸作为标记物的方法，用于鉴定与细胞色素 P450 代谢或不饱和脂肪酸氧化调节异常有关的疾病患者。在优选的实施方案中，亚油酸二醇，包括但不限于白细胞毒素二醇，被用作鉴定先兆子痫、子痫和妊娠诱发高血压患者的诊断工具。
• A NEW FAMILY OF PAIN PRODUCING SUBSTANCES AND METHODS TO PRODUCE NOVEL ANALGESIC DRUGS
  申请人：Board of Regents, The University of Texas System

  公开号：EP2381940A2

  公开（公告）日：2011-11-02
• EP2908849A1
  申请人：——

  公开号：EP2908849A1

  公开（公告）日：2015-08-26
• A METHOD TO IMPROVE PHARMACOKINETICS OF DRUGS
  申请人：Board of Regents, The University of Texas System

  公开号：EP2908849B1

  公开（公告）日：2019-04-17