3,4-二甲苯磺酸铵 | 26447-10-9

• 物质功能分类: 化学试剂 - 有机试剂 - 磺酸盐/亚磺酸盐
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,4-二甲苯磺酸铵
• 中文别名: 二甲基苯磺酸铵；二甲苯磺酸铵
• 英文名称: Ammonium xylenesulfonate
• 英文别名: azane;2,4-dimethylbenzenesulfonic acid
• CAS: 26447-10-9
• 化学式: C8H13NO3S
• 分子量: 203.26
• InChiKey: FGTOZJXFOAPXMR-UHFFFAOYSA-N

物化性质

• LogP：
  1.390 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  1.58
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  3

制备方法与用途

应用

3,4-二甲苯磺酸铵广泛用于医药化工领域。

用途

本品作为一种新型高效的低毒性洗涤用品增溶调理剂，被广泛应用于日用洗涤用品的制造。与使用传统增溶剂的产品相比，采用二甲苯磺酸铵的产品具有手感好、刺激性低和产品品质纯度高的特点。此外，该产品还常用于家庭清洗液的配制，因此越来越受到业内有识之士的关注和青睐。

文献信息

• Process for preparing optically active 2-[6-(hydroxy-methyl)-1,3-dioxan-4-yl] acetic acid derivatives
  申请人：Nishiyama Akira

  公开号：US20050080277A1

  公开（公告）日：2005-04-14

  The present invention is to provide a production technology by which an optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivative, which are of value as pharmaceutical intermediates, can be produced from inexpensive and readily available starting materials without using any extraordinary equipment such as an ultra-low-temperature reactor. The present invention is a production process of an optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivative which comprises reacting an enolate, prepared by permitting a base or a 0-valent metal to act on an acetic acid ester derivative with (S)-β-hydroxy-γ-butyrolactone at a temperature not lower than −30° C. to give a dihydroxyoxohexanoic acid derivative, treating the same with an acylating agent in the presence of a base to produce a dihydroxyoxohexanoic acid monoacyl derivative, reducing this compound with a microorganism to produce a trihydroxyhexanoic acid monoacyl derivative, treating this compound with an acetal-forming reagent in the presence of an acid catalyst to produce an acyloxymethyldioxanylacetic acid derivative, and finally, subjecting this compound to solvolysis in the presence of a base.

  本发明旨在提供一种生产技术，通过该技术可以从廉价且易得的起始材料中生产出具有药物中间体价值的光学活性2-[6-(羟甲基)-1,3-二氧杂环戊-4-基]乙酸衍生物，而无需使用任何特殊设备，如超低温反应器。本发明是一种光学活性2-[6-(羟甲基)-1,3-二氧杂环戊-4-基]乙酸衍生物的生产过程，包括将碱或0价金属作用于乙酸酯衍生物制备出的烯醇，与(S)-β-羟基-γ-丁内酯在不低于-30℃的温度下反应，得到二羟基氧代己酸衍生物，用酰化剂在碱的存在下处理，以产生二羟基氧代己酸单酰衍生物，用微生物还原该化合物以产生三羟基己酸单酰衍生物，用酸催化剂存在下的缩醛试剂处理该化合物，以产生酰氧甲基二氧杂环己酸衍生物，最后，在碱的存在下进行溶剂解离。
• PROCESS FOR PREPARING OPTICALLY ACTIVE 2- 6-(HYDROXY-METHYL)-1,3-DIOXAN-4-YL]ACETIC ACID DERIVATIVES
  申请人：KANEKA CORPORATION

  公开号：EP1288213A1

  公开（公告）日：2003-03-05

  The present invention is to provide a production technology by which an optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivative, which are of value as pharmaceutical intermediates, can be produced from inexpensive and readily available starting materials without using any extraordinary equipment such as an ultra-low-temperature reactor. The present invention is a production process of an optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivative    which comprises reacting an enolate, prepared by permitting a base or a 0-valent metal to act on an acetic acid ester derivative with (S)-β-hydroxy-γ-butyrolactone at a temperature not lower than -30°C to give a dihydroxyoxohexanoic acid derivative,    treating the same with an acylating agent in the presence of a base to produce a dihydroxyoxohexanoic acid monoacyl derivative,    reducing this compound with a microorganism to produce a trihydroxyhexanoic acid monoacyl derivative,    treating this compound with an acetal-forming reagent in the presence of an acid catalyst to produce an acyloxymethyldioxanylacetic acid derivative, and    finally, subjecting this compound to solvolysis in the presence of a base.

  本发明旨在提供一种生产技术，通过该技术，无需使用超低温反应器等任何特殊设备，即可从廉价易得的起始材料中生产出具有光学活性的 2-[6-(羟甲基)-1,3-二氧杂环戊烷-4-基]乙酸衍生物，该衍生物具有医药中间体的价值。 本发明是一种具有光学活性的 2-[6-(羟甲基)-1,3-二氧杂环戊烷-4-基]乙酸衍生物的生产工艺。 其中包括在不低于-30℃的温度下，将通过允许碱或 0 价金属作用于乙酸酯衍生物而制备的烯醇与(S)-β-羟基-γ-丁内酯反应，得到二羟基氧代己酸衍生物、 在碱存在下，用酰化剂处理该衍生物，生成二羟基氧代己酸单酰基衍生物、 用微生物还原该化合物，生成三羟基己酸单乙酰衍生物、 在酸催化剂存在下，用乙缩醛形成试剂处理该化合物，生成酰氧基甲基二氧杂环乙酸衍生物，以及 最后，使该化合物在碱存在下发生溶解反应。
• PROCESS FOR PREPARING OPTICALLY ACTIVE 2- 6-(HYDROXY-METHYL)-1,3-DIOXAN-4-YL|ACETIC ACID DERIVATIVES
  申请人：KANEKA CORPORATION

  公开号：EP1288213B1

  公开（公告）日：2006-11-29
• US4645623A
  申请人：——

  公开号：US4645623A

  公开（公告）日：1987-02-24
• US4687593A
  申请人：——

  公开号：US4687593A

  公开（公告）日：1987-08-18