N-n-propylamantadine | 3717-47-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-n-propylamantadine
• 英文别名: <1>Adamantyl-propyl-amin；1-Propylaminoadamantan；N-propyladamantan-1-amine
• CAS: 3717-47-3
• 化学式: C₁₃H₂₃N
• 分子量: 193.332
• InChiKey: HHXUWTNTZZFUGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-n-propylamantadine 以 环己烷 为溶剂， 生成 (3-Adamantan-1-yl-3-propyl-ureido)-acetic acid
  参考文献：
  名称：

  DE2052256

  摘要：

  公开号：
• 作为产物：
  描述：

  1-溴金刚烷 在 lithium aluminium tetrahydride 、 硫酸 作用下， 以 乙二醇二甲醚 为溶剂， 生成 N-n-propylamantadine
  参考文献：
  名称：

  抗病毒药。2.与1-金刚烷胺有关的化合物的构效关系。

  摘要：

  DOI：

  10.1021/jm00288a019

文献信息

• Stabilization of the hindered urea bond through de-<i>tert</i>-butylation
  作者：Yingfeng Yang、Hanze Ying、Yunchao Jia、Yingying Chen、Jianjun Cheng

  DOI：10.1039/d1cc00715g

  日期：——

  A facile acid-assisted de-tert-butylation reaction that can instantly “turn off” the dynamicity of hindered urea bonds (HUBs) and stabilize HUB-containing structures.

  一种简便的酸辅助的脱tert-丁基化反应，可以立即“关闭”受阻尿素键（HUBs）的动态性并稳定含有HUB的结构。
• DERIVATIVES OF FLUORENE, ANTHRACENE, XANTHENE, DIBENZOSUBERONE AND ACRIDINE AND USES THEREOF
  申请人：Cholody Wieslaw M.

  公开号：US20100137354A1

  公开（公告）日：2010-06-03

  Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/β-catenin signaling pathway, and serve to reduce β-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.

  本发明涉及化学剂，例如荧光烯，蒽，三苯甲烷和吖啶的二磺酰胺衍生物，以及类似的杂环环结构及其盐，这些化学剂作为抗癌和抗肿瘤剂，特别是当这些剂调节Wnt/β-连环蛋白信号通路的活性时，并能降低β-连环蛋白在细胞中（如癌细胞）的水平，或当这些剂调节细胞系统（包括癌细胞）的基因表达水平时。此外，本发明还揭示了制备这些化学剂的方法，以及包含这些化学剂作为活性成分的制药组合物和使用它们作为治疗剂的方法。
• Oxypentafluorosulfate compositions and processes for making them
  申请人：Air Products and Chemicals, Inc.

  公开号：EP1889832A2

  公开（公告）日：2008-02-20

  A molecular compound represented by the formula ZOSF5, is prepared by combining a reagent represented by the formula Y+ -OSF5 with a substrate represented by the formula ZL, where L is a leaving group, in an organic solvent. Y is either an inorganic cation, in which case a complexing agent is also present, or an organic cation. Z is C1-20 alkyl, aryl, cycloalkyl, combinations thereof, or analogues thereof containing at least one heteroatom. Novel compounds ZOSF5 as can be made using such a process, and novel reactants Y+ -OSF5 used in such a process as well as processes of making the same, are also described.

  将式 Y+ -OSF5 所代表的试剂与式 ZL 所代表的底物（其中 L 为离去基团）在有机溶剂中结合，可制备式 ZOSF5 所代表的分子化合物。Y 既可以是无机阳离子（在这种情况下还需要络合剂），也可以是有机阳离子。Z 是 C1-20 烷基、芳基、环烷基、其组合或含有至少一个杂原子的类似物。此外，还描述了可使用这种工艺制作的新型化合物 ZOSF5，以及在这种工艺中使用的新型反应物 Y+ -OSF5 以及制造这种化合物的工艺。
• PARENTERAL TREATMENTS INVOLVING AMINOADAMANTANE DERIVATIVES
  申请人：Singh Sachdeva Gurparatap

  公开号：US20200315991A1

  公开（公告）日：2020-10-08

  A method and composition is described for treating impaired neurological function, CNS disease or condition, including altered state of consciousness disorders in a human subject, comprising parenterally administering a composition comprising aminoadamantane derivatives or salts thereof, alone or in combination with other neuroprotective and/or anti-inflammatory compounds, in a pharmacologically effective amount. In some embodiments, a method for treating traumatic brain injury caused by a stroke or an accident in a human subject is provided comprising intravenously administering a composition comprising amantadine hydrochloride in a pharmacologically effective amount to the subject in need thereof.
• US8129519B2
  申请人：——

  公开号：US8129519B2

  公开（公告）日：2012-03-06