作者:D. M. CHANNING、P. B. TURNER、G. T. YOUNG
DOI:10.1038/167487a0
日期:1951.3
THE ‘carbobenzyloxy’ method of peptide synthesis1 has proved its value in many important syntheses. Nevertheless, the practical difficulties still encountered in this field suggest that improved protecting groups should still be sought. We have recently been examining benzyl chloroformates substituted in the benzene ring, and other closely related compounds, in the hope that the amino-acid and peptide
肽合成的“苄氧基”方法已在许多重要的合成中证明了其价值。尽管如此,该领域仍遇到的实际困难表明仍应寻求改进的保护基团。我们最近一直在研究苯环中取代的氯甲酸苄酯和其他密切相关的化合物,希望氨基酸和肽衍生物更容易结晶,以及其他特性,例如稳定性和易于去除保护基团, 可能会有所不同,以增加这种合成方法的范围。