carbamoyl-phenoxy-thioacetic acid S-methyl ester | 1294450-10-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: carbamoyl-phenoxy-thioacetic acid S-methyl ester
• 英文别名: S-methyl 3-amino-3-oxo-2-phenoxypropanethioate
• CAS: 1294450-10-4
• 化学式: C₁₀H₁₁NO₃S
• 分子量: 225.268
• InChiKey: ATLKMSSTAFQQHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  94.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(4-methoxyphenyl)-4,4-bis-methylsulfanyl-3-phenoxyazetidin-2-one 在 ammonium cerium (IV) nitrate 作用下， 以50%的产率得到carbamoyl-phenoxy-thioacetic acid S-methyl ester
  参考文献：
  名称：

  4,4-Bis(methylthio)azetidin-2-ones as synthons of 1,2- and 1,3-dicarbonyl systems

  摘要：

  The importance of beta-lactams as synthetic building blocks has been widely recognized in organic synthesis due to possible ring cleavage at any of the four single bonds of the beta-lactam ring. We now report reactions involving breaking of the N1-C4 bond in differently substituted at C3 4,4-bis(methylthio)azetidin-2-ones, leading to formation of 1,2- and 1,3-dicarbonyl systems. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.02.046

文献信息

• 4,4-Bis(methylthio)azetidin-2-ones as synthons of 1,2- and 1,3-dicarbonyl systems
  作者：Monika I. Konaklieva、Lita S. Suwandi、Maya Kostova、Jeffrey Deschamps

  DOI：10.1016/j.tetlet.2011.02.046

  日期：2011.4

  The importance of beta-lactams as synthetic building blocks has been widely recognized in organic synthesis due to possible ring cleavage at any of the four single bonds of the beta-lactam ring. We now report reactions involving breaking of the N1-C4 bond in differently substituted at C3 4,4-bis(methylthio)azetidin-2-ones, leading to formation of 1,2- and 1,3-dicarbonyl systems. (C) 2011 Elsevier Ltd. All rights reserved.