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2-Amino-5-methylindan | 61957-30-0

中文名称
——
中文别名
——
英文名称
2-Amino-5-methylindan
英文别名
4-Methyl-2-amino-indan;2-amino-4-methylindane;4-methyl-indan-2-ylamine;4-Methyl-2,3-dihydro-1H-inden-2-amine
2-Amino-5-methylindan化学式
CAS
61957-30-0
化学式
C10H13N
mdl
MFCD19204666
分子量
147.22
InChiKey
CAHLQEOQFRTFQB-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    1.7
  • 重原子数:
    11
  • 可旋转键数:
    0
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.4
  • 拓扑面积:
    26
  • 氢给体数:
    1
  • 氢受体数:
    1

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

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文献信息

  • SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS
    申请人:Chow Ken
    公开号:US20080255239A1
    公开(公告)日:2008-10-16
    Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.
    本文揭示了治疗化合物、方法、组合物和相关药物。
  • Acylated indanyl amines and their use as pharmaceuticals
    申请人:——
    公开号:US20030055093A1
    公开(公告)日:2003-03-20
    The present invention relates to acylated indanyl amines according to the general formula (I) 1 wherein R 1 -R 4 have the meanings given in the description, A is CH 2 , CHOH or CH—(C 1 -C 3 -alkyl), B is CH 2 or CH—(C 1 -C 3 -alkyl), and R 5 is an aryl or heteroaryl group, possibly substituted by the substituents listed in the description. These compounds are useful in the upregulation of endothelial nitric oxide synthase (eNOS), and may therefore be useful for the manufacture of medicaments for the treatment of cardiovascular diseases, stable or unstable angina pectoris, coronary heart disease, Prinzmetal angina, acute coronary syndrome, heart failure, myocardial infarction, stroke, thrombosis, peripheral artery occlusive disease, endothelial dysfunction, atherosclerosis, restenosis, endothelial damage after PTCA, hypertension, essential hypertension, pulmonary hypertension, secondary hypertension, renovascular hypertension, chronic glomerulonephritis, erectile dysfunction, ventricular arrhythmia, diabetes or diabetes complications, nephropathy or retinopathy, angiogenesis, asthma bronchiale, chronic renal failure, cirrhosis of the liver, osteoporosis, restricted memory performance, a restricted ability to learn, or for the lowering of cardiovascular risk of postmenopausal women or after intake of contraceptives.
    本发明涉及通式(I)中的酰化的茚基胺,其中R1-R4具有描述中给出的含义,A为CH2、CHOH或CH—(C1-C3-烷基),B为CH2或CH—(C1-C3-烷基),R5为芳基或杂芳基,可能被描述中列出的取代基取代。这些化合物在上调内皮型一氧化氮合酶(eNOS)方面有用,因此可能用于制造用于治疗心血管疾病、稳定或不稳定心绞痛、冠心病、普林兹梅塔心绞痛、急性冠状综合征、心力衰竭、心肌梗死、中风、血栓形成、周围动脉闭塞性疾病、内皮功能障碍、动脉粥样硬化、再狭窄、PTCA后内皮损伤、高血压、原发性高血压、肺动脉高压、继发性高血压、肾血管性高血压、慢性肾小球肾炎、勃起功能障碍、室性心律失常、糖尿病或糖尿病并发症、肾病或视网膜病变、血管生成、支气管哮喘、慢性肾功能衰竭、肝硬化、骨质疏松症、记忆力受限、学习能力受限,或用于降低绝经后妇女或口服避孕药后心血管风险。
  • ACYLATED INDANYL AMINES AND THEIR USE AS PHARMACEUTICALS
    申请人:STROBEL Hartmut
    公开号:US20070082897A1
    公开(公告)日:2007-04-12
    The present invention relates to acylated indanyl amines according to the general formula (I) wherein R 1 —R 4 have the meanings given in the description, A is CH 2 , CHOH or CH—(C 1 -C 3 -alkyl), B is CH 2 or CH—(C 1 -C 3 -alkyl), and R 5 is an aryl or heteroaryl group, possibly substituted by the substituents listed in the description. These compounds are useful in the upregulation of endothelial nitric oxide synthase (eNOS), and may therefore be useful for the manufacture of medicaments for the treatment of cardiovascular diseases, stable or unstable angina pectoris, coronary heart disease, Prinzmetal angina, acute coronary syndrome, heart failure, myocardial infarction, stroke, thrombosis, peripheral artery occlusive disease, endothelial dysfunction, atherosclerosis, restenosis, endothelial damage after PTCA, hypertension, essential hypertension, pulmonary hypertension, secondary hypertension, renovascular hypertension, chronic glomerulonephritis, erectile dysfunction, ventricular arrhythmia, diabetes or diabetes complications, nephropathy or retinopathy, angiogenesis, asthma bronchiale, chronic renal failure, cirrhosis of the liver, osteoporosis, restricted memory performance, a restricted ability to learn, or for the lowering of cardiovascular risk of postmenopausal women or after intake of contraceptives.
    本发明涉及通式(I)的酰化吲哚基胺,其中R1-R4具有描述中给出的含义,A为CH2,CHOH或CH-(C1-C3-烷基),B为CH2或CH-(C1-C3-烷基),而R5为芳基或杂芳基基团,可能被描述中列出的取代基所取代。这些化合物有助于上调内皮型一氧化氮合酶(eNOS),因此可能用于制造用于治疗心血管疾病、稳定或不稳定型心绞痛、冠心病、普林兹梅塔尔心绞痛、急性冠状动脉综合征、心力衰竭、心肌梗死、中风、血栓形成、周围动脉闭塞症、内皮功能障碍、动脉粥样硬化、再狭窄、PTCA后的内皮损伤、高血压、原发性高血压、肺动脉高压、继发性高血压、肾血管性高血压、慢性肾小球肾炎、勃起功能障碍、室性心律失常、糖尿病或糖尿病并发症、肾病或视网膜病变、血管生成、支气管哮喘、慢性肾衰竭、肝硬化、骨质疏松症、受限制的记忆表现、受限制的学习能力或降低绝经后妇女或口服避孕药后的心血管风险。
  • THERAPEUTIC AGENT FOR CEREBRAL INFARCTION
    申请人:Mitsubishi Tanabe Pharma Corporation
    公开号:EP2486925A1
    公开(公告)日:2012-08-15
    The present invention aims to provide a therapeutic drug for ischemic stroke. The present invention relates to a therapeutic drug for ischemic stroke containing an amide derivative represented by the following formula (I) wherein each symbol is as defined in the DESCRIPTION, or a pharmacologically acceptable salt thereof, or a solvate thereof, as an active ingredient.
    本发明旨在提供一种治疗缺血性中风的药物。 本发明涉及一种治疗缺血性中风的药物,其活性成分含有下式(I)所代表的酰胺衍生物,其中各符号如描述文件中所定义,或其药理学上可接受的盐,或其溶液。
  • Binge behavior regulators
    申请人:Golan Ezekiel
    公开号:US10137096B2
    公开(公告)日:2018-11-27
    Methods and compositions utilizing 2-aminoindan derivatives collectively represented by Formula I as described and defined in the specification for regulating binge behavior, particularly binge drinking, are disclosed.
    本发明公开了利用说明书中描述和定义的式 I 所代表的 2-氨基茚满衍生物来调节酗酒行为,特别是酗酒的方法和组合物。
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