2-fluoro-5-methylterephthalic acid | 1203953-06-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-fluoro-5-methylterephthalic acid
• CAS: 1203953-06-3
• 化学式: C₉H₇FO₄
• 分子量: 198.151
• InChiKey: QZHLPHCAKBZZFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-fluoro-5-methylterephthalic acid 、 碘甲烷 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 dimethyl 2-fluoro-5-methylterephthalate
  参考文献：
  名称：

  TRIAZOLE DERIVATIVE OR SALT THEREOF

  摘要：

  公开号：

  EP2298747B1
• 作为产物：
  描述：

  2-氟-5-甲基对苯二甲腈 在 硫酸 、 水 作用下， 反应 48.0h， 生成 2-fluoro-5-methylterephthalic acid
  参考文献：
  名称：

  TRIAZOLE DERIVATIVE OR SALT THEREOF

  摘要：

  公开号：

  EP2298747B1

文献信息

• Substituted nitrogen-containing heterobicycles, the preparation thereof and their use as pharmaceutical compositions
  申请人：Boehringer Ingelheim Pharma GmbH & Co. KG

  公开号：US20040176603A1

  公开（公告）日：2004-09-09

  The present invention relates to new substituted nitrogen-containing heterobicyclic compounds of general formula 1 wherein B, X 1 to X 3 and R 1 to R 5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties. The compounds of the above general formula I as well as the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, and their stereoisomers have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.

  本发明涉及一种新的取代氮杂双环化合物，其一般式为1，其中B、X1至X3和R1至R5如权利要求1所定义，其互变异构体、对映异构体、非对映异构体、混合物及其盐，特别是与无机或有机酸或碱形成的生理上可接受的盐，具有有价值的性质。上述一般式I化合物及其互变异构体、对映异构体、非对映异构体、混合物及其盐，特别是与无机或有机酸或碱形成的生理上可接受的盐及其立体异构体具有有价值的药理学性质，特别是抗血栓活性和Xa因子抑制活性。
• Triazole derivative or salt thereof
  申请人：Yoshimura Seiji

  公开号：US08377923B2

  公开（公告）日：2013-02-19

  [Problem] A compound, which can be used for preventing or treating diseases, in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, in particular, diabetes, insulin resistance, dementia, schizophrenia and depression, is provided. [Means for Solution] It was found that a triazole derivative, in which one of the 3- and 5-positions of the triazole ring has (di)alkylmethyl or cycloalkyl, each of which is substituted with —O— (aryl or a heterocyclic group, each of which may be substituted, or lower alkylene-cycloalkyl), and the other thereof has aryl, a heterocyclic group or cycloalkyl, each of which may be substituted, or a pharmaceutically acceptable salt thereof exhibits potent 11β-HSD1 inhibitory action. From the above, the triazole derivative of the present invention can be used for preventing or treating diabetes, insulin resistance, dementia, schizophrenia and depression.

  [问题] 提供了一种可以用于预防或治疗疾病的化合物，其中涉及11β-羟基类固醇脱氢酶1型（11β-HSD1），特别是糖尿病、胰岛素抵抗、痴呆症、精神分裂症和抑郁症。 [解决方法] 发现三唑衍生物，其中三唑环的3位和5位中的一个具有（二）烷基甲基或环烷基，每个都被取代为- O-（芳基或杂环基，每个都可以被取代，或较低的烷基-环烷基），而其另一个具有芳基，杂环基或环烷基，每个都可以被取代，或其药学上可接受的盐，表现出强效的11β-HSD1抑制作用。从上述可以得出，本发明的三唑衍生物可用于预防或治疗糖尿病、胰岛素抵抗、痴呆症、精神分裂症和抑郁症。
• SUBSTITUTED NITROGEN-CONTAINING HETEROBICYCLES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
  申请人：Priepke Henning

  公开号：US20090181958A1

  公开（公告）日：2009-07-16

  The present invention relates to new substituted nitrogen-containing heterobicyclic compounds of general formula wherein B, X 1 to X 3 and R 1 to R 5 are defined as in claim 1 , the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties. The compounds of the above general formula I as well as the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, and their stereoisomers have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.

  本发明涉及一种新的取代氮含杂双环化合物，其一般式为B，X1至X3和R1至R5如权利要求1所定义，其互变异构体、对映异构体、非对映异构体、其混合物以及其盐，特别是其与无机或有机酸或碱的生理可接受盐，具有有价值的特性。上述一般式I的化合物以及其互变异构体、对映异构体、非对映异构体、其混合物以及其盐，特别是其与无机或有机酸或碱的生理可接受盐和其立体异构体具有有价值的药理特性，特别是抗血栓活性和Xa因子抑制活性。
• US7429597B2
  申请人：——

  公开号：US7429597B2

  公开（公告）日：2008-09-30
• US8377923B2
  申请人：——

  公开号：US8377923B2

  公开（公告）日：2013-02-19