N-benzyl-N-pyridin-2-ylethenesulfonamide | 736178-00-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-benzyl-N-pyridin-2-ylethenesulfonamide
• CAS: 736178-00-0
• 化学式: C₁₄H₁₄N₂O₂S
• 分子量: 274.343
• InChiKey: CQXZLHSPKXYTQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  58.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-benzyl-N-pyridin-2-ylethenesulfonamide 在 过氧化双月桂酰 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 1,2-二氯乙烷 、 邻二氯苯 为溶剂， 生成 2-(1-benzyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-2-yl)-1-(4-methoxy-phenyl)-ethanone
  参考文献：
  名称：

  A new approach for the ortho -substitution of anilines and for the synthesis of indolines

  摘要：

  Intermolecular radical addition of a xanthate to a vinyl sulfanilide is followed by ring closure to the aromatic ring to give a dihydrobenzoisothiazole dioxide structure, which upon heating loses sulfur dioxide to give a 2-substituted aniline; in some examples, the presence of DBU during heating induces the formation of an indoline. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.04.111
• 作为产物：
  描述：

  2-苄氨基吡啶 、 2-氯乙烷磺酰氯 在 三乙胺 作用下， 生成 N-benzyl-N-pyridin-2-ylethenesulfonamide
  参考文献：
  名称：

  A new approach for the ortho -substitution of anilines and for the synthesis of indolines

  摘要：

  Intermolecular radical addition of a xanthate to a vinyl sulfanilide is followed by ring closure to the aromatic ring to give a dihydrobenzoisothiazole dioxide structure, which upon heating loses sulfur dioxide to give a 2-substituted aniline; in some examples, the presence of DBU during heating induces the formation of an indoline. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.04.111

文献信息

• A new approach for the ortho -substitution of anilines and for the synthesis of indolines
  作者：Cécile Moutrille、Samir Z. Zard

  DOI：10.1016/j.tetlet.2004.04.111

  日期：2004.6

  Intermolecular radical addition of a xanthate to a vinyl sulfanilide is followed by ring closure to the aromatic ring to give a dihydrobenzoisothiazole dioxide structure, which upon heating loses sulfur dioxide to give a 2-substituted aniline; in some examples, the presence of DBU during heating induces the formation of an indoline. (C) 2004 Elsevier Ltd. All rights reserved.