(E)-3-[2-[(4-chlorophenyl)methoxy]phenyl]-3-imidazol-1-yl-N,N-dimethyl-prop-2-en-1-amine | 108649-22-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (E)-3-[2-[(4-chlorophenyl)methoxy]phenyl]-3-imidazol-1-yl-N,N-dimethyl-prop-2-en-1-amine
• 英文别名: (E)-3-[2-[(4-chlorophenyl)methoxy]phenyl]-3-imidazol-1-yl-N,N-dimethylprop-2-en-1-amine
• CAS: 108649-22-5
• 化学式: C₂₁H₂₂ClN₃O
• 分子量: 367.878
• InChiKey: ISWGRZIXFXZLRY-RGVLZGJSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  30.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(dimethylamino)-1-(2-hydroxyphenyl)propan-1-one hydrochloride 在 sodium hydride 作用下， 以 二氯甲烷 为溶剂， 反应 0.83h， 生成 (E)-3-[2-[(4-chlorophenyl)methoxy]phenyl]-3-imidazol-1-yl-N,N-dimethyl-prop-2-en-1-amine
  参考文献：
  名称：

  Synthesis and antifungal activity of new 1-vinylimidazoles

  摘要：

  Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III. Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imidazole transfer reaction, were alkylated to furnish the title compounds V. The structure-activity relationships of these 1-vinylimidazole compounds V are described.

  DOI：

  10.1021/jm00391a014

文献信息

• Synthesis and antifungal activity of new 1-vinylimidazoles
  作者：Masaru Ogata、Hiroshi Matsumoto、Sumio Shimizu、Shiro Kida、Motoo Shiro、Katsuya Tawara

  DOI：10.1021/jm00391a014

  日期：1987.8

  Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III. Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imidazole transfer reaction, were alkylated to furnish the title compounds V. The structure-activity relationships of these 1-vinylimidazole compounds V are described.