3,5-二甲基全氢-1,3,5-噁二嗪-4-硫酮 | 25952-35-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫脲类
• 中文名称: 3,5-二甲基全氢-1,3,5-噁二嗪-4-硫酮
• 英文名称: 3,5-dimethyl-[1,3,5]oxadiazinane-4-thione
• 英文别名: 3,5-dimethyl-tetrahydro-[1,3,5]oxadiazine-4-thione；3,5-Dimethyl-tetrahydro-[1,3,5]oxadiazin-4-thion；tetrahydro-3,5-dimethyl-4H-1,3,5-oxadiazine-4-thione；3,5-Dimethyltetrahydro-4H-1,3,5-oxadiazin-4-thion；4H-1,3,5-Oxadiazine-4-thione, tetrahydro-3,5-dimethyl-；3,5-dimethyl-1,3,5-oxadiazinane-4-thione
• CAS: 25952-35-6
• 化学式: C₅H₁₀N₂OS
• 分子量: 146.213
• InChiKey: SDWKXMBJXPQCJU-UHFFFAOYSA-N

物化性质

• 密度：
  1.141 (estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  47.8
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  3,5-二甲基全氢-1,3,5-噁二嗪-4-硫酮 、 巴比妥酸 反应 12.0h， 生成
  参考文献：
  名称：

  8和8,10取代的巴比妥及其硫代类似物的首次合成

  摘要：

  烷基（硫）脲，甲醛和（硫）巴比妥酸的多组分缩合反应提供了新的螺杂环化合物，即8和8,10-取代的2,4,8,10-四氮杂螺[5.5]十一烷-1,3 ，5,9-丁酮（巴比妥类药物）及其硫代类似物。

  DOI：

  10.1016/j.mencom.2019.01.032
• 作为产物：
  描述：

  聚合甲醛 、 N,N'-二甲基硫脲 在 盐酸 、 水 作用下， 反应 2.0h， 生成 3,5-二甲基全氢-1,3,5-噁二嗪-4-硫酮
  参考文献：
  名称：

  8和8,10取代的巴比妥及其硫代类似物的首次合成

  摘要：

  烷基（硫）脲，甲醛和（硫）巴比妥酸的多组分缩合反应提供了新的螺杂环化合物，即8和8,10-取代的2,4,8,10-四氮杂螺[5.5]十一烷-1,3 ，5,9-丁酮（巴比妥类药物）及其硫代类似物。

  DOI：

  10.1016/j.mencom.2019.01.032

文献信息

• Clinical Characteristics and Six-Month Outcomes of Nursing Home Residents With Low Activities of Daily Living Dependency
  作者：A. Buttar、C. Blaum、B. Fries

  DOI：10.1093/gerona/56.5.m292

  日期：2001.5.1

  Background. Up to 30% of nursing home residents have very little dependency in activities of daily living (ADLs). We compared the characteristics and six-month outcomes of a sample of low-ADL-dependent nursing home residents (LDR) with other residents.Methods. This is a cross-sectional, six-month follow-up study using secondary data analysis. We combined the separate 1990 and 1993 cohorts in the Resident Assessment Instrument evaluation study. In each case these data were collected in the same 254 nursing homes in 10 states. We studied residents with a length of stay greater than 60 days and age 65 years and older (N = 3955). We compared the baseline characteristics of LDR (n = 985) with all other residents. We then compared six-month outcomes of LDR with other residents and characteristics of LDR with poor outcomes (death or worsened ADL disability) with LDR who remained stable.Results. The LDR had a significantly decreased frequency of geriatric syndromes (i.e., cognitive impairment, urinary incontinence, under-nutrition, vision problems, poor balance, and pressure ulcers) and neurological disease but had the same frequency of non-neurological chronic diseases and were on more medications. Thirty-one percent had poor six-month outcomes associated with baseline poor cognition, incontinence, poor appetite, and presence of vascular disease, daily pain, shortness of breath, and multiple medications.Conclusion. Our research identified 29% of nursing home residents with higher physical function (LDR) who had fewer geriatric syndromes and neurological disease diagnoses; 69% of these remained stable at 6 months. Those LDR with a higher risk of poor outcomes could be prospectively identified. LDR who remained stable for 6 months may represent a group who could potentially be maintained in the community.
• Seidel,M.C.; Boettner,F.E., Journal of Heterocyclic Chemistry, 1972, vol. 9, p. 231 - 234
  作者：Seidel,M.C.、Boettner,F.E.

  DOI：——

  日期：——