3,5-二甲氧基-N-苯基苯甲酰胺 | 87282-04-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,5-二甲氧基-N-苯基苯甲酰胺
• 英文名称: 3,5-dimethoxy-N-phenylbenzamide
• 英文别名: N-phenyl-3,5-dimethoxybenzamide；3,5-dimethoxybenzanilide；3,5-dimethoxy-benzoic acid anilide；3,5-Dimethoxy-benzoesaeure-anilid；3,5-dimethoxybenzamido-benzene
• CAS: 87282-04-0
• 化学式: C₁₅H₁₅NO₃
• 分子量: 257.289
• InChiKey: ISUQCAAJIKTSIX-UHFFFAOYSA-N

物化性质

• 沸点：
  348.2±32.0 °C(Predicted)
• 密度：
  1.189±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,5-二甲氧基-N-苯基苯甲酰胺 在 五氯化磷 、 甲苯 作用下， 生成 3,5-二甲氧基苯甲醛
  参考文献：
  名称：

  Asahina; Matsuzaki, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1924, # 509, p. 2

  摘要：

  DOI：
• 作为产物：
  描述：

  3,5-二甲氧基苯甲酸 在 乙醚 、 五氯化磷 作用下， 生成 3,5-二甲氧基-N-苯基苯甲酰胺
  参考文献：
  名称：

  Core-level and valence-band characteristics of carbon nitride films with high nitrogen content

  摘要：

  Carbon nitride films with high nitrogen content were prepared by reactive pulsed-laser deposition at nitrogen partial pressures varying from 0.1 to 20.0 Torr. It was found that the nitrogen content in the films first increases with increase of the nitrogen pressure, reaches a maximum of 46 at. % at 5.0 Torr, and then decreases to 37 at. % at 20.0 Torr. The almost pure carbon nitride films were systematically characterized by using X-ray photoelectron spectroscopy (XPS) concerning the core-level and valence-band structures. Some fingerprint information, which shows the role of nitrogen in controlling the electronic structure of carbon nitride films, was found based on the XPS studies. With enhancing the nitrogen incorporation, both the binding energy and the peak intensity of the core-level and the valence-band spectra vary systematically as a function of nitrogen content in the films.

  DOI：

  10.1007/s003390000620

文献信息

• Facile CuI-Catalyzed Arylation of Azoles and Amides Using Simple Enaminones as Efficient Ligands
  作者：Cuirong Sun、Cungui Cheng、Gonglei Sun、Jieping Wan

  DOI：10.1055/s-0029-1217958

  日期：2009.10

  found to be an excellent ligand for copper-catalyzed N-arylation of azoles and amides with aryl halides under mild conditions. The reaction took place at 82 °C in MeCN with broad functional-group compatibility. A combination of the ligand and CuI proved to be an efficient catalytic system to promote the coupling reactions of aryl halides with azoles and amides.

  (E)-3-(二甲氨基)-1-(2-羟基苯基)prop-2-en-1-one 被发现是铜催化的唑类和酰胺与芳基卤化物在温和条件下 N-芳基化的极好配体. 该反应在具有广泛官能团兼容性的 MeCN 中于 82°C 下进行。配体和CuI的组合被证明是促进芳基卤化物与唑类和酰胺偶联反应的有效催化体系。
• A Convenient Synthesis of<i>N</i>-Aryl Benzamides by Rhodium-Catalyzed<i>ortho</i>-Amidation and Decarboxylation of Benzoic Acids
  作者：Xian-Ying Shi、Ke-Yan Liu、Juan Fan、Xue-Fen Dong、Jun-Fa Wei、Chao-Jun Li

  DOI：10.1002/chem.201406031

  日期：2015.1.26

  The rhodium‐catalyzed amidation of substituted benzoic acids with isocyanates by directed CH functionalization followed by decarboxylation to afford the corresponding N‐aryl benzamides is demonstrated, in which the carboxylate serves as a unique, removable directing group. Notably, less common meta‐substituted N‐aryl benzamides are generated readily from more accessible para‐ or ortho‐substituted

  证明了铑通过直接CH官能化与异氰酸酯催化的取代苯甲酸酰胺化反应，然后脱羧得到相应的N-芳基苯甲酰胺，其中羧酸盐是一个独特的可移动的导向基团。值得注意的是，采用这种策略，容易从较易接近的对位或邻位取代的基团中生成较不常见的间位取代的N-芳基苯甲酰胺。
• Amide bond synthesis via silver(I) N-heterocyclic carbene-catalyzed and tert-butyl hydroperoxide-mediated oxidative coupling of alcohols with amines under base free conditions
  作者：Ramesh Balaboina、Narasimha Swamy Thirukovela、Ravinder Vadde、Chandra Sekhar Vasam

  DOI：10.1016/j.tetlet.2019.02.024

  日期：2019.3

  free method for amide bond construction via oxidative coupling of alcohols with amines catalyzed by Silver(I) N-heterocyclic carbenes (Ag(I)-NHCs) and mediated by tert-butyl hydroperoxide (TBHP) in ethanol. The results of controlled experiments suggest that the oxidative coupling proceeds through the formation of aldehyde, then subsequent attack by amine to give hemiaminal, which can then be oxidized

  我们提出了一种通过醇与胺的氧化偶联进行酰胺键构建的无碱方法，该胺被银（I）N-杂环卡宾（Ag（I）-NHCs）催化，并由叔丁基过氧化氢（TBHP）在乙醇中介导。对照实验的结果表明，氧化偶合通过醛的形成而进行，然后被胺攻击以生成半缩醛，然后可以将其氧化为酰胺。
• [EN] DERIVATIVES OF 1 H-PYRAZOLO[3,4-B]PYRIDINE AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS<br/>[FR] DÉRIVÉS DE 1H-PYRAZOLO[3,4-B]PYRIDINE ET SES COMPOSITIONS PHARMACEUTIQUES PERMETTANT LE TRAITEMENT DE TROUBLES PROLIFÉRATIFS
  申请人：GALAPAGOS NV

  公开号：WO2015024905A1

  公开（公告）日：2015-02-26

  The present invention discloses compounds according to Formula (I): wherein R1, R2, R3, R4, L, and X are as defined herein. The present invention relates to compounds,methods for their production, pharmaceutical compositions comprising the same, and their use in the prophylaxis and/or treatment of inflammatory conditions, type 2 diabetes, neurological and/or neurodegenerative diseases, autoimmune diseases, proliferative diseases (in particular metastatic diseases, and/or cancer), abnormal angiogenesis associated diseases, degradation of cartilage, and/or disruption of cartilage homeostasis, in particular in the prophylaxis and/or treatment of cancer. The present invention also discloses methods of treatment using the same compounds, for the prophylaxis and/or treatment of said diseases by administering the compound of the invention.

  本发明公开了根据以下式（I）的化合物：其中R1、R2、R3、R4、L和X如本文所定义。本发明涉及化合物、其生产方法、包含相同化合物的药物组合物，以及它们在预防和/或治疗炎症性疾病、2型糖尿病、神经和/或神经退行性疾病、自身免疫疾病、增生性疾病（特别是转移性疾病和/或癌症）、异常血管生成相关疾病、软骨降解和/或软骨稳态紊乱，特别是在预防和/或治疗癌症方面的用途。本发明还公开了使用相同化合物的治疗方法，通过给予本发明化合物的方式预防和/或治疗上述疾病。
• Facile access to amides and hydroxamic acids directly from nitroarenes
  作者：Shreyans K. Jain、K. A. Aravinda Kumar、Sandip B. Bharate、Ram A. Vishwakarma

  DOI：10.1039/c4ob01155d

  日期：——

  for synthesis of amides and hydroxamic acids from nitroarenes and aldehydes is described. The MnO2 catalyzed thermal deoxygenation of nitrobenzene resulted in formation of a reactive nitroso intermediate which on reaction with aldehydes provided amides and hydroxamic acids. The thermal neat reaction in the presence of 0.01 mmol KOH predominantly led to formation of hydroxamic acid whereas reaction

  描述了一种由硝基芳烃和醛合成酰胺和异羟肟酸的新方法。MnO 2催化硝基苯的热脱氧导致形成反应性亚硝基中间体，该中间体在与醛反应后提供酰胺和异羟肟酸。在0.01mmol KOH存在下的热纯反应主要导致异羟肟酸的形成，而在1mmol乙酸存在下的反应产生酰胺作为唯一产物。