(S)-4-chloro-N-(1-(5-fluoropyrimidin-2-yl)ethyl)-6-methoxypyrimidin-2-amine | 1080622-80-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (S)-4-chloro-N-(1-(5-fluoropyrimidin-2-yl)ethyl)-6-methoxypyrimidin-2-amine
• 英文别名: 4-chloro-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-6-methoxypyrimidin-2-amine
• CAS: 1080622-80-5
• 化学式: C₁₁H₁₁ClFN₅O
• 分子量: 283.693
• InChiKey: PAMMIOVRVAUMQZ-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-氨基-5-甲基噻唑 、 (S)-4-chloro-N-(1-(5-fluoropyrimidin-2-yl)ethyl)-6-methoxypyrimidin-2-amine 在 tris-(dibenzylideneacetone)dipalladium(0) 、 caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 1,4-二氧六环 为溶剂， 生成 (S)-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-6-methoxy-N4-(5-methylthiazol-2-yl)pyrimidine-2,4-diamine
  参考文献：
  名称：

  Replacement of pyrazol-3-yl amine hinge binder with thiazol-2-yl amine: Discovery of potent and selective JAK2 inhibitors

  摘要：

  Thiazol-2-yl amine was identified as an isosteric replacement for pyrazol-3-yl amine during our efforts to identify potent and selective JAK2 inhibitors. The rationale, synthesis and biological evaluation of several analogs is reported, along with the in vivo evaluation of the lead compounds. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.091
• 作为产物：
  描述：

  2,4-二氯-6-甲氧基嘧啶 、 (S)-1-(5-氟嘧啶-2-基)乙胺盐酸盐 在 N,N-二异丙基乙胺 作用下， 以 正丁醇 为溶剂， 生成 (S)-4-chloro-N-(1-(5-fluoropyrimidin-2-yl)ethyl)-6-methoxypyrimidin-2-amine 、 (S)-2-chloro-N-(1-(5-fluoropyrimidin-2-yl)ethyl)-6-methoxypyrimidin-4-amine
  参考文献：
  名称：

  Replacement of pyrazol-3-yl amine hinge binder with thiazol-2-yl amine: Discovery of potent and selective JAK2 inhibitors

  摘要：

  Thiazol-2-yl amine was identified as an isosteric replacement for pyrazol-3-yl amine during our efforts to identify potent and selective JAK2 inhibitors. The rationale, synthesis and biological evaluation of several analogs is reported, along with the in vivo evaluation of the lead compounds. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.091

文献信息

• AMINO-THIAZOLYL-PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER
  申请人：Almeida Lynsie

  公开号：US20100204231A1

  公开（公告）日：2010-08-12

  The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer.

  本发明涉及式(I)的化合物及其制药组合物和使用方法。这些化合物提供了治疗骨髓增生性疾病和癌症的治疗方法。
• AMINO-THIAZOLYL- PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER
  申请人：AstraZeneca AB

  公开号：EP2152702B1

  公开（公告）日：2011-08-24
• Replacement of pyrazol-3-yl amine hinge binder with thiazol-2-yl amine: Discovery of potent and selective JAK2 inhibitors
  作者：Stephanos Ioannidis、Michelle L. Lamb、Lynsie Almeida、Huiping Guan、Bo Peng、Geraldine Bebernitz、Kirsten Bell、Marat Alimzhanov、Michael Zinda

  DOI：10.1016/j.bmcl.2010.01.091

  日期：2010.3

  Thiazol-2-yl amine was identified as an isosteric replacement for pyrazol-3-yl amine during our efforts to identify potent and selective JAK2 inhibitors. The rationale, synthesis and biological evaluation of several analogs is reported, along with the in vivo evaluation of the lead compounds. (C) 2010 Elsevier Ltd. All rights reserved.