3,5-双(4-乙酰氨基苯氧基)苯甲酸 | 575450-27-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,5-双(4-乙酰氨基苯氧基)苯甲酸
• 英文名称: Benzoic acid, 3,5-bis[4-(acetylamino)phenoxy]-
• 英文别名: 3,5-bis(4-acetamidophenoxy)benzoic acid
• CAS: 575450-27-0
• 化学式: C₂₃H₂₀N₂O₆
• 分子量: 420.422
• InChiKey: MTMORLNJAWGCRF-UHFFFAOYSA-N

物化性质

• 沸点：
  716.6±60.0 °C(Predicted)
• 密度：
  1.359±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3,5-双(4-乙酰氨基苯氧基)苯甲酸 在 氯化亚砜 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 0.5h， 生成 3,5-Bis-(4-acetylamino-phenoxy)-benzoyl chloride
  参考文献：
  名称：

  Facile Synthesis of Polyamide Dendrimers from Unprotected AB₂ Building Blocks

  摘要：

  A fast, inexpensive, and highly efficient synthesis of aromatic polyamide dendrimers; without the need for protection and deprotection steps has been developed. Dendrons and third-generation polyamide dendrimers were easily prepared by a convergent approach involving activation of a focal point with thionyl chloride, followed by condensation with unprotected AB(2) building blocks.

  DOI：

  10.1021/ol035595s
• 作为产物：
  描述：

  溶剂黄146 、 3,5-二(4-氨基苯氧基)苯甲酸 在 (2,3-二氢-2-硫酮-3-苯并唑)膦酸二苯酯 、 三乙胺 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 2.0h， 以90%的产率得到3,5-双(4-乙酰氨基苯氧基)苯甲酸
  参考文献：
  名称：

  Rapid Synthesis of Polyamide Dendrimers from Unprotected AB₂ Building Blocks

  摘要：

  A rapid synthetic method for the preparation of polyamide dendrimer without protection and deprotection steps has been developed. A symmetrically branched third-generation polyamide dendrimer was prepared by a convergent method involving activation of focal point with a condensing agent, diphenyl (2,3-dihydro-2-thioxo-3-benzoxazolyl)phosphonate (DBOP), followed by condensation of the active amide with the diaminocarboxylic acid 3,5-bis(4-aminophenoxy)benzoic acid as an AB2 building block.

  DOI：

  10.1021/ja034665n

文献信息

• Facile Synthesis of Polyamide Dendrimers from Unprotected AB₂ Building Blocks:  Dumbbell-Shaped Dendrimer, Star-Shaped Dendrimer, and Dendrimer with a Carboxylic Acid at the Core
  作者：Isao Washio、Yuji Shibasaki、Mitsuru Ueda

  DOI：10.1021/ma0478456

  日期：2005.3.1

  AB2 building block, 3,5-bis(4-aminophenoxy)benzoic acid. A third generation dendrimer with a molecular weight of 8197 Da was prepared in a high yield, using 1,3,5-tris[N-(4-aminophenyl)]benzenetricarboxamide as a core molecule. A dendrimer with a carboxylic acid group at its core (molecular weight:  10 700 Da) could be prepared from the third generation dendron with 3,5-bis(3,5-diaminobenzoylamino)benzoic

  已经开发了不需要保护和脱保护步骤的快速，廉价和高效的芳族聚酰胺树枝状大分子的合成方法。树枝状结构和各种类型的聚酰胺树枝状聚合物很容易通过收敛方法制备，该方法包括使用少量过量的亚硫酰氯作为活化剂在焦点处活化羧酸，然后与未保护的AB 2结构单元3,5缩合。-双（4-氨基苯氧基）苯甲酸。使用1,3,5-tris [ N-（4-氨基苯基）]苯三甲酰胺为核心分子。可以从以3,5-双（3,5-二氨基苯甲酰基氨基）苯甲酸为核心分子的第三代树枝状分子制备在其核心（分子量：10 700 Da）处具有羧酸基的树枝状聚合物。仅通过沉淀纯化的所有上述产物显示出高纯度，使用基质辅助激光解吸电离飞行时间质谱法进行评估。
• MICROCHEMICAL NANOFACTORIES
  申请人：Paul Brian Kevin

  公开号：US20120298037A1

  公开（公告）日：2012-11-29

  Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement synthetic processes, disclosed embodiments of the apparatus generally include at least one unit operation, such as a mixer, a valve, a separator, a detector, and combinations thereof. Individual apparatuses may be coupled both in series and in parallel to form a system for making chemical compounds. An individual apparatus or a system also can be used in combination with known devices and processes.
• Facile Synthesis of Polyamide Dendrimers from Unprotected AB₂ Building Blocks
  作者：Isao Washio、Yuji Shibasaki、Mitsuru Ueda

  DOI：10.1021/ol035595s

  日期：2003.10.1

  A fast, inexpensive, and highly efficient synthesis of aromatic polyamide dendrimers; without the need for protection and deprotection steps has been developed. Dendrons and third-generation polyamide dendrimers were easily prepared by a convergent approach involving activation of a focal point with thionyl chloride, followed by condensation with unprotected AB(2) building blocks.
• Rapid Synthesis of Polyamide Dendrimers from Unprotected AB₂ Building Blocks
  作者：Masaki Okazaki、Isao Washio、Yuji Shibasaki、Mitsuru Ueda

  DOI：10.1021/ja034665n

  日期：2003.7.1

  A rapid synthetic method for the preparation of polyamide dendrimer without protection and deprotection steps has been developed. A symmetrically branched third-generation polyamide dendrimer was prepared by a convergent method involving activation of focal point with a condensing agent, diphenyl (2,3-dihydro-2-thioxo-3-benzoxazolyl)phosphonate (DBOP), followed by condensation of the active amide with the diaminocarboxylic acid 3,5-bis(4-aminophenoxy)benzoic acid as an AB2 building block.